HitPredict - High confidence protein-protein interactions

Method score	Annotation score	Interaction score
0.93	1.00	0.965

Method score

Annotation score

Interaction score

0.93

1.00

0.965

Property	Details
Experiments	26221961, 28934360, 34880843, 33110251, 19036819, 19193783, 24379373
Identification Methods	affinity chromatography technology, pull down, two hybrid, bioluminescence resonance energy transfer, anti tag coimmunoprecipitation, fluorescent resonance energy transfer
Interaction Type	physical association, direct interaction

Property

Details

Experiments

26221961, 28934360, 34880843, 33110251, 19036819, 19193783, 24379373

Identification Methods

affinity chromatography technology, pull down, two hybrid, bioluminescence resonance energy transfer, anti tag coimmunoprecipitation, fluorescent resonance energy transfer

Interaction Type

physical association, direct interaction

Property	Details
Interacting Pfam domains	CARD_2~CARD_2
Common GO terms	GO:0000151 - ubiquitin ligase complex GO:0001934 - positive regulation of protein phosphorylation GO:0002218 - activation of innate immune response GO:0002230 - positive regulation of defense response to virus by host GO:0002735 - positive regulation of myeloid dendritic cell cytokine production and 37 others more... GO:0002753 - cytoplasmic pattern recognition receptor signaling pathway GO:0005739 - mitochondrion GO:0005741 - mitochondrial outer membrane GO:0005778 - peroxisomal membrane GO:0007165 - signal transduction GO:0019901 - protein kinase binding GO:0031966 - mitochondrial membrane GO:0032481 - positive regulation of type I interferon production GO:0032727 - positive regulation of interferon-alpha production GO:0032728 - positive regulation of interferon-beta production GO:0032755 - positive regulation of interleukin-6 production GO:0032757 - positive regulation of interleukin-8 production GO:0032760 - positive regulation of tumor necrosis factor production GO:0035591 - signaling adaptor activity GO:0039552 - RIG-I binding GO:0042307 - positive regulation of protein import into nucleus GO:0042742 - defense response to bacterium GO:0043123 - positive regulation of canonical NF-kappaB signal transduction GO:0045071 - negative regulation of viral genome replication GO:0045087 - innate immune response GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0050700 - CARD domain binding GO:0051091 - positive regulation of DNA-binding transcription factor activity GO:0051607 - defense response to virus GO:0060090 - molecular adaptor activity GO:0060337 - type I interferon-mediated signaling pathway GO:0060339 - negative regulation of type I interferon-mediated signaling pathway GO:0060340 - positive regulation of type I interferon-mediated signaling pathway GO:0060760 - positive regulation of response to cytokine stimulus GO:0070585 - protein localization to mitochondrion GO:0071360 - cellular response to exogenous dsRNA GO:0071651 - positive regulation of chemokine (C-C motif) ligand 5 production GO:0071660 - positive regulation of IP-10 production GO:0140374 - antiviral innate immune response GO:0140693 - molecular condensate scaffold activity GO:1900063 - regulation of peroxisome organization GO:1900227 - positive regulation of NLRP3 inflammasome complex assembly
Homologous interactions	13