HitPredict

Interactor 1: ARVC (O00192)
Splicing regulator ARVCF (Armadillo repeat protein deleted in velo-cardio-facial syndrome)
Gene: ARVCF

Interactor 2: CADH1 (P12830)
Cadherin-1 (CAM 120/80) (Epithelial cadherin) (E-cadherin) (Uvomorulin) (CD antigen CD324) [Cleaved into: E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3]
Gene: CDH1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	25468996
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Arm~CADH_Y-type_LIR
Common GO terms	GO:0005886 - plasma membrane GO:0005912 - adherens junction GO:0007043 - cell-cell junction assembly GO:0045296 - cadherin binding GO:0098609 - cell-cell adhesion
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 962 Hs			1 882
+	Mm
		454953 ARVC_MOUSE (1-962): 0: 879: 91.60		CADH1_MOUSE (1-882): 0: 799: 81.45
+	Mm
		544706 ARVC_MOUSE (1-962): 0: 879: 91.60		CADH2_MOUSE (28-881): 0: 762: 46.43
+	Hs
		119755 ARVC_HUMAN (1-962): 0: 869: 100.00		CADH2_HUMAN (28-881): 0: 769: 45.86
+	Hs
		239034 CTND1_HUMAN (1-933): 0: 750: 46.14		CADH1_HUMAN (1-882): 0: 836: 100.00
+	Mm
		454947 CTND1_MOUSE (1-933): 0: 773: 46.39		CADH1_MOUSE (1-882): 0: 799: 81.45
+	Mm
		544697 CTND1_MOUSE (1-933): 0: 773: 46.39		CADH2_MOUSE (28-881): 0: 762: 46.43
+	Hs
		239048 CTND1_HUMAN (1-933): 0: 750: 46.14		CADH2_HUMAN (28-881): 0: 769: 45.86
+	Hs
		239052 CTND1_HUMAN (1-933): 0: 750: 46.14		CADH3_HUMAN (3-882): 0: 716: 53.06
+	Hs
		522286 PKP3_HUMAN (19-852): 9.74e-160: 491: 26.20		CADH1_HUMAN (1-882): 0: 836: 100.00
+	Hs
		971080 PKP3_HUMAN (19-852): 9.74e-160: 491: 26.20		DSC2_HUMAN (33-874): 0: 652: 27.88
+	Mm
		702740 ARVC_MOUSE (1-962): 0: 879: 91.60		CAD15_MOUSE (1-585): 8.83e-57: 211: 18.33
+	Hs
		119759 ARVC_HUMAN (1-962): 0: 869: 100.00		CADH5_HUMAN (30-511): 8.2e-52: 196: 20.91
+	Hs
		119763 ARVC_HUMAN (1-962): 0: 869: 100.00		CAD12_HUMAN (1-365): 6.76e-47: 182: 19.79
+	Hs
		119762 ARVC_HUMAN (1-962): 0: 869: 100.00		CADH8_HUMAN (1-365): 8.09e-45: 175: 20.84
+	Hs
		119764 ARVC_HUMAN (1-962): 0: 869: 100.00		CAD15_HUMAN (20-408): 3.58e-37: 152: 17.08
+	Hs
		239097 CTND1_HUMAN (1-933): 0: 750: 46.14		CAD11_HUMAN (3-481): 2.6e-77: 269: 20.16
+	Mm
		677630 CTND1_MOUSE (1-933): 0: 773: 46.39		CADH5_MOUSE (30-511): 2.45e-49: 189: 21.06
+	Hs
		239063 CTND1_HUMAN (1-933): 0: 750: 46.14		CADH5_HUMAN (30-511): 8.2e-52: 196: 20.91
+	Hs
		239096 CTND1_HUMAN (1-933): 0: 750: 46.14		CADH8_HUMAN (1-365): 8.09e-45: 175: 20.84
+	Hs
		239165 CTND1_HUMAN (1-933): 0: 750: 46.14		CAD24_HUMAN (1-365): 1.92e-34: 143: 19.14