Protein: COIA1
Collagen alpha-1(XVIII) chain [Cleaved into: Endostatin; Non-collagenous domain 1 (NC1)]

Gene: COIA1, COL18A1
Organism: Homo sapiens
Interactions: 101
UniProt ID: P39060

Gene Ontology (top 5):
GO:0001501 - skeletal system development
GO:0001525 - angiogenesis
GO:0001886 - endothelial cell morphogenesis
GO:0005576 - extracellular region
GO:0005581 - collagen trimer

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

810589

COIA1
Collagen alpha-1(XVIII) chain [Cleaved into: Endostatin; Non-collagenous domain 1

5

15

Small-scale

0.930

High

505804

C1T9A
Complement C1q and tumor necrosis factor-related protein 9A

3

20

High-throughput

0.861

High

668774

CO8A2
Collagen alpha-2(VIII) chain

3

20

High-throughput

0.847

High

73781

C1T9B
Complement C1q and tumor necrosis factor-related protein 9B

1

20

High-throughput

0.691

High

388700

C1QB
Complement C1q subcomponent subunit B

1

20

High-throughput

0.691

High

388771

C1QC
Complement C1q subcomponent subunit C

1

20

High-throughput

0.691

High

694312

CO8A1
Collagen alpha-1(VIII) chain

1

19

High-throughput

0.691

High

810606

ADIPO
Adiponectin

1

20

High-throughput

0.691

High

810632

C1QT1
Complement C1q tumor necrosis factor-related protein 1

1

20

High-throughput

0.691

High

810633

C1QT7
Complement C1q tumor necrosis factor-related protein 7

1

20

High-throughput

0.691

High

810640

COLQ
Acetylcholinesterase collagenic tail peptide

1

18

High-throughput

0.691

High

469667

MMP2
72 kDa type IV collagenase

4

20

Small-scale

0.687

High

575781

MMP9
Matrix metalloproteinase-9

3

20

Small-scale

0.670

High

421630

A4
Amyloid-beta precursor protein

3

8

Small-scale

0.664

High

384125

CO1A1
Collagen alpha-1(I) chain

1

19

Small-scale

0.647

High

384308

CO4A1

1

16

Small-scale

0.647

High

551766

CO6A1

1

19

Small-scale

0.647

High

810602

PTC1
Protein patched homolog 1

3

0

High-throughput

0.638

High

620178

NUCL
Nucleolin

2

0

Small-scale

0.632

High

388503

CRP

2

1

High-throughput

0.628

High

810599

PLOD1
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1

2

20

High-throughput

0.628

High

810618

C1QL4
Complement C1q-like protein 4

2

20

High-throughput

0.628

High

810595

DEF1
Neutrophil defensin 1

2

0

High-throughput

0.602

High

191298

P4HA2
Prolyl 4-hydroxylase subunit alpha-2

2

10

High-throughput

0.601

High

251867

PLOD3
Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 [Includes: Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3

2

20

High-throughput

0.601

High

810611

LAIR2
Leukocyte-associated immunoglobulin-like receptor 2

2

17

High-throughput

0.601

High

810635

SIAE
Sialate O-acetylesterase

2

0

High-throughput

0.585

High

431734

ITB1
Integrin beta-1

2

3

Small-scale

0.585

High

810609

Q4VAQ0
COL8A2 protein

1

20

High-throughput

0.575

High

810629

TRI11
E3 ubiquitin-protein ligase TRIM11

2

1

High-throughput

0.574

High

810597

PGBM
Basement membrane-specific heparan sulfate proteoglycan core protein

1

10

Small-scale

0.552

High

810604

PCOC1
Procollagen C-endopeptidase enhancer 1

1

1

Small-scale

0.536

High

518818

CCL3
C-C motif chemokine 3

1

4

High-throughput

0.536

High

566928

P4HA1
Prolyl 4-hydroxylase subunit alpha-1

1

10

High-throughput

0.536

High

598254

CL3L1
C-C motif chemokine 3-like 1

1

4

High-throughput

0.536

High

810594

MFAP4
Microfibril-associated glycoprotein 4

1

2

High-throughput

0.536

High

810598

IL5RA
Interleukin-5 receptor subunit alpha

1

1

High-throughput

0.536

High

810619

SFPA2
Pulmonary surfactant-associated protein A2

1

19

High-throughput

0.536

High

810620

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

1

High-throughput

0.536

High

810621

GT252
Procollagen galactosyltransferase 2

1

20

High-throughput

0.536

High

810625

CC4L
C-C motif chemokine 4-like

1

4

High-throughput

0.536

High

810626

CA054
Uncharacterized protein C1orf54

1

1

High-throughput

0.536

High

810638

DNJB9
DnaJ homolog subfamily B member 9

1

2

High-throughput

0.536

High

810639

FBX2
F-box only protein 2

1

4

High-throughput

0.536

High

472390

FGF4
Fibroblast growth factor 4

1

0

High-throughput

0.513

High

506830

CFC1
Cryptic protein

1

0

High-throughput

0.513

High

567809

PRG2
Bone marrow proteoglycan

1

0

High-throughput

0.513

High

810600

SG2A2
Mammaglobin-A

1

0

High-throughput

0.513

High

810601

OS9
Protein OS-9

1

0

High-throughput

0.513

High

810631

ADPGK
ADP-dependent glucokinase

1

0

High-throughput

0.513

High

810636

SDF2L
Stromal cell-derived factor 2-like protein 1

1

0

High-throughput

0.513

High

447992

ITAV
Integrin alpha-V

1

7

Small-scale

0.501

High

464425

TSP1
Thrombospondin-1

1

7

Small-scale

0.501

High

482677

SPRC
SPARC

1

5

Small-scale

0.501

High

562834

CCL2
C-C motif chemokine 2

1

4

Small-scale

0.501

High

570758

LYAM1
L-selectin

1

3

Small-scale

0.501

High

591911

LYAM3
P-selectin

1

2

Small-scale

0.501

High

641297

PGS1
Biglycan

1

5

Small-scale

0.501

High

642520

TGM2
Protein-glutamine gamma-glutamyltransferase 2

1

4

Small-scale

0.501

High

673757

LAMA1
Laminin subunit alpha-1

1

11

Small-scale

0.501

High

778031

VGFR2
Vascular endothelial growth factor receptor 2

1

2

Small-scale

0.501

High

593298

PGFRA
Platelet-derived growth factor receptor alpha

1

2

High-throughput

0.489

High

217912

TGON2
Trans-Golgi network integral membrane protein 2

1

8

High-throughput

0.479

High

371356

MYC
Myc proto-oncogene protein

1

2

High-throughput

0.479

High

387803

FIBB
Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain]

1

2

High-throughput

0.479

High

400410

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

3

High-throughput

0.479

High

534736

BIP
Endoplasmic reticulum chaperone BiP

1

4

High-throughput

0.479

High

810593

MFAP2
Microfibrillar-associated protein 2

1

1

Small-scale

0.479

High

810614

OLFM4
Olfactomedin-4

1

2

High-throughput

0.479

High

810617

TMM25
Transmembrane protein 25

1

2

High-throughput

0.479

High

810607

E2F4
Transcription factor E2F4

1

0

High-throughput

0.458

High

810627

LIPH
Lipase member H

1

0

High-throughput

0.458

High

810630

ITCH
E3 ubiquitin-protein ligase Itchy homolog

1

0

High-throughput

0.458

High

810634

ACE2
Angiotensin-converting enzyme 2

1

0

Small-scale

0.458

High

473671

ITA5
Integrin alpha-5

1

7

Small-scale

0.445

High

105484

APRIO
Alternative prion protein

1

8

High-throughput

0.437

High

348992

LATS1
Serine/threonine-protein kinase LATS1

1

3

High-throughput

0.437

High

774893

FUS
RNA-binding protein FUS

1

2

High-throughput

0.437

High

810590

YAP1
Transcriptional coactivator YAP1

1

1

Small-scale

0.437

High

810615

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

810628

OPTN
Optineurin

1

1

High-throughput

0.437

High

810637

FBX6
F-box only protein 6

1

4

High-throughput

0.437

High

529249

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.426

High

810592

GPC3
Glypican-3

1

0

High-throughput

0.426

High

810608

TAZ
Tafazzin

3

0

High-throughput

0.347

High

482847

TPM1
Tropomyosin alpha-1 chain

2

0

Small-scale

0.322

High

395623

ESR1
Estrogen receptor

2

0

High-throughput

0.298

High

426059

PPB1
Alkaline phosphatase, placental type

1

0

High-throughput

0.279

Low

810605

EPHA7
Ephrin type-A receptor 7

1

0

High-throughput

0.279

Low

810612

IFIX
Pyrin and HIN domain-containing protein 1

1

0

High-throughput

0.279

Low

810616

TCPR1
Tectonin beta-propeller repeat-containing protein 1

1

0

High-throughput

0.279

Low

810623

CAMKV
CaM kinase-like vesicle-associated protein

1

0

High-throughput

0.279

Low

810603

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

0

High-throughput

0.251

Low

655726

TBG1
Tubulin gamma-1 chain

1

0

High-throughput

0.249

Low

810591

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.249

Low

810596

SC61B
Protein transport protein Sec61 subunit beta

1

0

High-throughput

0.249

Low

810613

RICTR
Rapamycin-insensitive companion of mTOR

1

0

High-throughput

0.249

Low

810624

TNIP2
TNFAIP3-interacting protein 2

1

0

High-throughput

0.249

Low

810610

LITD1
LINE-1 type transposase domain-containing protein 1

1

0

High-throughput

0.232

Low

810622

AHI1
Jouberin

1

0

Small-scale

0.232

Low


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Last updated: 11Aug2025