HitPredict

Interactor 1: PB1 (Q86U86)
Protein polybromo-1 (hPB1) (BRG1-associated factor 180) (BAF180) (Polybromo-1D)
Gene: PBRM1

Interactor 2: ESR2 (Q92731)
Estrogen receptor beta (ER-beta) (Nuclear receptor subfamily 3 group A member 2)
Gene: ESR2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	29509190, 21182203
Identification Methods	affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006357 - regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1689 Hs			1 530
+	Hs
		369920 PB1_HUMAN (1-1689): 0: 1223: 100.00		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		782587 PB1_HUMAN (1-1689): 0: 1223: 100.00		HNF4A_HUMAN (94-502): 1.21e-107: 331: 23.30
+	Hs
		377443 PB1_HUMAN (1-1689): 0: 1223: 100.00		GCR_HUMAN (3-495): 1.12e-103: 330: 22.64
+	Mm
		101534 F8VQD1_MOUSE (1-1689): 0: 1207: 97.30		ERR2_MOUSE (69-499): 5.26e-107: 328: 31.11
+	Mm
		1142677 PB1_MOUSE (1-1689): 0: 1168: 91.95		ERR2_MOUSE (69-499): 5.26e-107: 328: 31.11
+	Hs
		487563 PB1_HUMAN (1-1689): 0: 1223: 100.00		ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59
+	Hs
		1067076 BRD3_HUMAN (358-959): 6.75e-48: 186: 12.76		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		369975 TAF1L_HUMAN (3-420): 2.75e-57: 221: 15.84		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		369636 BRD3_HUMAN (358-959): 6.75e-48: 186: 12.76		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		1269570 BRD8_HUMAN (301-506): 2.43e-17: 90.8: 14.55		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		611472 PHIP_HUMAN (480-1024): 4.44e-53: 207: 13.50		NR4A1_HUMAN (7-501): 3.18e-101: 318: 25.30
+	Hs
		369011 BRD2_HUMAN (2-169): 7.14e-20: 98.6: 15.29		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		370401 BRD8_HUMAN (301-506): 2.43e-17: 90.8: 14.55		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		587198 BRD8_HUMAN (301-506): 2.43e-17: 90.8: 14.55		RXRA_HUMAN (13-502): 1.6e-119: 361: 25.71
+	Hs
		631369 BRD2_HUMAN (2-169): 7.14e-20: 98.6: 15.29		HNF4A_HUMAN (94-502): 1.21e-107: 331: 23.30
+	Hs
		782651 BRD8_HUMAN (301-506): 2.43e-17: 90.8: 14.55		HNF4A_HUMAN (94-502): 1.21e-107: 331: 23.30
+	Hs
		487129 TAF1_HUMAN (457-963): 1.08e-57: 223: 16.79		ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59
+	Hs
		487449 BRD3_HUMAN (358-959): 6.75e-48: 186: 12.76		ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59
+	Hs
		487141 BRD2_HUMAN (2-169): 7.14e-20: 98.6: 15.29		ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59
+	Hs
		487750 BRD8_HUMAN (301-506): 2.43e-17: 90.8: 14.55		ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59