HitPredict

Interactor 1: RHOD (O00212)
Rho-related GTP-binding protein RhoD (Rho-related protein HP1) (RhoHP1)
Gene: RHOD

Interactor 2: M4K4 (O95819)
Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (HPK/GCK-like kinase HGK) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (Nck-interacting kinase)
Gene: MAP4K4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~Ras
Common GO terms	GO:0030335 - positive regulation of cell migration
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 210 Hs			1 1239
+	Hs
		324886 RHOF_HUMAN (7-193): 1.18e-78: 236: 54.26		M4K4_HUMAN (1-1239): 0: 1227: 100.00
+	Hs
		324783 RAC1_HUMAN (15-202): 3.58e-77: 231: 50.00		M4K4_HUMAN (1-1239): 0: 1227: 100.00
+	Hs
		1233546 RHOF_HUMAN (7-193): 1.18e-78: 236: 54.26		MINK1_HUMAN (1-1239): 0: 1120: 59.29
+	Hs
		120535 RHOD_HUMAN (1-210): 1.91e-77: 232: 100.00		MINK1_HUMAN (1-1239): 0: 1120: 59.29
+	Hs
		925434 RAC1_HUMAN (15-202): 3.58e-77: 231: 50.00		MINK1_HUMAN (1-1239): 0: 1120: 59.29
+	Mm
		925783 RAC1_MOUSE (15-202): 3.58e-77: 231: 50.00		TNIK_MOUSE (1-1239): 0: 1120: 62.43
+	Hs
		925356 RAC1_HUMAN (15-202): 3.58e-77: 231: 50.00		MRCKG_HUMAN (13-974): 7.6e-138: 459: 17.29
+	Hs
		647964 RHOF_HUMAN (7-193): 1.18e-78: 236: 54.26		MARK3_HUMAN (16-665): 4.1e-127: 411: 16.23
+	Hs
		120307 RHOD_HUMAN (1-210): 1.91e-77: 232: 100.00		MARK3_HUMAN (16-665): 4.1e-127: 411: 16.23
+	Hs
		647868 RAC1_HUMAN (15-202): 3.58e-77: 231: 50.00		MARK3_HUMAN (16-665): 4.1e-127: 411: 16.23
+	Hs
		148653 RAC1_HUMAN (15-202): 3.58e-77: 231: 50.00		CTRO_HUMAN (14-616): 3.12e-117: 405: 22.33
+	Hs
		1183126 RHOF_HUMAN (7-193): 1.18e-78: 236: 54.26		MARK2_HUMAN (8-669): 2.09e-122: 399: 14.10
+	Hs
		120505 RHOD_HUMAN (1-210): 1.91e-77: 232: 100.00		MARK2_HUMAN (8-669): 2.09e-122: 399: 14.10
+	Hs
		925384 RAC1_HUMAN (15-202): 3.58e-77: 231: 50.00		MARK2_HUMAN (8-669): 2.09e-122: 399: 14.10
+	Hs
		681775 RAC1_HUMAN (15-202): 3.58e-77: 231: 50.00		AKT1_HUMAN (2-354): 2.35e-122: 388: 20.82
+	Hs
		254515 RHOF_HUMAN (7-193): 1.18e-78: 236: 54.26		ROCK2_HUMAN (15-536): 8.84e-107: 369: 22.02
+	Hs
		120238 RHOD_HUMAN (1-210): 1.91e-77: 232: 100.00		ROCK2_HUMAN (15-536): 8.84e-107: 369: 22.02
+	Hs
		254468 RAC1_HUMAN (15-202): 3.58e-77: 231: 50.00		ROCK2_HUMAN (15-536): 8.84e-107: 369: 22.02
+	Hs
		925763 RAC1_HUMAN (15-202): 3.58e-77: 231: 50.00		M4K5_HUMAN (4-375): 4.65e-107: 359: 39.52
+	Mm
		823530 RAC1_MOUSE (15-202): 3.58e-77: 231: 50.00		CTRO_MOUSE (304-593): 4.37e-10: 66.7: 14.56