HitPredict

Interactor 1: STING (Q86WV6)
Stimulator of interferon genes protein (hSTING) (Endoplasmic reticulum interferon stimulator) (ERIS) (Mediator of IRF3 activation) (hMITA) (Transmembrane protein 173)
Gene: STING1

Interactor 2: UBP35 (Q9P2H5)
Ubiquitin carboxyl-terminal hydrolase 35 (EC 3.4.19.12) (Deubiquitinating enzyme 35) (Ubiquitin thioesterase 35) (Ubiquitin-specific-processing protease 35)
Gene: USP35

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.670

Property	Details
Experiments	32678307, 27801882, 36357379
Identification Methods	affinity chromatography technology, pull down, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 379 Hs			1 1018
+	Mm
		112092 STING_MOUSE (1-378): 0: 588: 69.05		M0QWN7_MOUSE (1-1018): 0: 1037: 88.11
+	Mm
		1111213 STING_MOUSE (1-378): 0: 588: 69.05		UBP33_MOUSE (350-991): 6.71e-99: 334: 16.90
+	Mm
		1111067 STING_MOUSE (1-378): 0: 588: 69.05		UBP20_MOUSE (350-986): 2.4e-90: 311: 16.99
+	Hs
		1203594 STING_HUMAN (1-379): 0: 572: 100.00		UBP20_HUMAN (350-986): 1.77e-91: 314: 17.74
+	Hs
		271135 STING_HUMAN (1-379): 0: 572: 100.00		UBP2_HUMAN (660-930): 5.02e-41: 162: 18.91
+	Hs
		1203593 STING_HUMAN (1-379): 0: 572: 100.00		UBP22_HUMAN (622-926): 7.16e-41: 160: 15.12
+	Hs
		1203599 STING_HUMAN (1-379): 0: 572: 100.00		UBP3_HUMAN (689-934): 3.55e-38: 152: 21.62
+	Mm
		1110762 STING_MOUSE (1-378): 0: 588: 69.05		UBP7_MOUSE (750-997): 8.76e-30: 130: 22.22
+	Hs
		1203592 STING_HUMAN (1-379): 0: 572: 100.00		UBP18_HUMAN (755-923): 8.41e-11: 67: 25.68