Protein: AKAP8
A-kinase anchor protein 8 (AKAP-8) (A-kinase anchor protein 95 kDa) (AKAP 95)

Gene: AKAP8
Organism: Homo sapiens
Interactions: 188
UniProt ID: O43823

Gene Ontology (top 5):
GO:0000278 - mitotic cell cycle
GO:0000793 - condensed chromosome
GO:0001939 - female pronucleus
GO:0003690 - double-stranded DNA binding
GO:0003723 - RNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

228942

MYC
Myc proto-oncogene protein

4

5

High-throughput

0.694

High

228943

ESR1
Estrogen receptor

4

10

High-throughput

0.683

High

228952

ROA1
Heterogeneous nuclear ribonucleoprotein A1

3

2

Small-scale

0.656

High

229009

CUL3
Cullin-3

3

4

High-throughput

0.656

High

228956

KAP2
cAMP-dependent protein kinase type II-alpha regulatory subunit

3

0

Small-scale

0.646

High

228976

FUS
RNA-binding protein FUS

2

6

High-throughput

0.611

High

228980

MATR3
Matrin-3

2

3

High-throughput

0.611

High

228968

CCND1
G1/S-specific cyclin-D1

2

4

Small-scale

0.601

High

229105

CLC11
C-type lectin domain family 11 member A

2

0

High-throughput

0.585

High

228997

EWS
RNA-binding protein EWS

2

5

High-throughput

0.584

High

229007

TIF1B
Transcription intermediary factor 1-beta

2

5

High-throughput

0.584

High

229066

MYCBP
c-Myc-binding protein

2

0

Small-scale

0.580

High

229055

ESR2
Estrogen receptor beta

2

10

High-throughput

0.571

High

228982

MCM2
DNA replication licensing factor MCM2

1

0

Small-scale

0.561

High

228971

CCND3
G1/S-specific cyclin-D3

1

4

Small-scale

0.552

High

133067

FOXE1
Forkhead box protein E1

1

6

High-throughput

0.536

High

165681

PPE1
Serine/threonine-protein phosphatase with EF-hands 1

1

3

High-throughput

0.536

High

188115

HDAC3
Histone deacetylase 3

1

3

Small-scale

0.536

High

221900

FOXS1
Forkhead box protein S1

1

5

High-throughput

0.536

High

228950

SNRPA
U1 small nuclear ribonucleoprotein A

1

4

High-throughput

0.536

High

228951

RU1C
U1 small nuclear ribonucleoprotein C

1

2

High-throughput

0.536

High

228955

TOP1
DNA topoisomerase 1

1

2

High-throughput

0.536

High

228957

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

1

High-throughput

0.536

High

228960

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

3

High-throughput

0.536

High

228972

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

1

High-throughput

0.536

High

228973

1433B
14-3-3 protein beta/alpha

1

5

High-throughput

0.536

High

228985

FOXG1
Forkhead box protein G1

1

5

High-throughput

0.536

High

228986

FOXA3
Hepatocyte nuclear factor 3-gamma

1

6

High-throughput

0.536

High

228988

WDR5
WD repeat-containing protein 5

1

2

Small-scale

0.536

High

228989

1433G
14-3-3 protein gamma

1

5

High-throughput

0.536

High

228993

1433Z
14-3-3 protein zeta/delta

1

5

High-throughput

0.536

High

229001

1433F
14-3-3 protein eta

1

5

High-throughput

0.536

High

229002

SSRP1
FACT complex subunit SSRP1

1

7

High-throughput

0.536

High

229008

ILK
Scaffold protein ILK

1

1

High-throughput

0.536

High

229010

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

3

High-throughput

0.536

High

229017

OASL
2'-5'-oligoadenylate synthase-like protein

1

1

High-throughput

0.536

High

229020

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

1

High-throughput

0.536

High

229039

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

3

High-throughput

0.536

High

229040

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

1

High-throughput

0.536

High

229045

HIPK4
Homeodomain-interacting protein kinase 4

1

3

High-throughput

0.536

High

229061

HDA11
Histone deacetylase 11

1

6

High-throughput

0.536

High

229064

RBM14
RNA-binding protein 14

1

3

High-throughput

0.536

High

229071

FOXC2
Forkhead box protein C2

1

5

High-throughput

0.536

High

229074

FOXP3
Forkhead box protein P3

1

6

High-throughput

0.536

High

229085

DDX21
Nucleolar RNA helicase 2

1

4

High-throughput

0.536

High

229090

FOXJ2
Forkhead box protein J2

1

5

High-throughput

0.536

High

229092

ASH2L
Set1/Ash2 histone methyltransferase complex subunit ASH2

1

2

Small-scale

0.536

High

229107

LMBL1
Lethal(3)malignant brain tumor-like protein 1

1

1

High-throughput

0.536

High

228962

DDX5
Probable ATP-dependent RNA helicase DDX5

1

1

Small-scale

0.527

High

228995

CSK21
Casein kinase II subunit alpha

1

0

High-throughput

0.527

High

229018

EZH2
Histone-lysine N-methyltransferase EZH2

1

1

High-throughput

0.515

High

228946

HG2A
HLA class II histocompatibility antigen gamma chain

1

0

High-throughput

0.513

High

228987

RHOA
Transforming protein RhoA

1

0

High-throughput

0.513

High

228991

1433E
14-3-3 protein epsilon

1

0

High-throughput

0.513

High

229011

TFDP1
Transcription factor Dp-1

1

0

High-throughput

0.513

High

229026

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

Small-scale

0.513

High

229056

CSN5
COP9 signalosome complex subunit 5

1

0

High-throughput

0.513

High

229058

PIGT
GPI-anchor transamidase component PIGT

1

0

High-throughput

0.513

High

229065

PASK
PAS domain-containing serine/threonine-protein kinase

1

0

High-throughput

0.513

High

229067

CDC5L
Cell division cycle 5-like protein

1

0

High-throughput

0.513

High

229076

DPY30
Protein dpy-30 homolog

1

0

Small-scale

0.513

High

229100

NAGK
N-acetyl-D-glucosamine kinase

1

0

High-throughput

0.513

High

228938

KLF8
Krueppel-like factor 8

1

7

High-throughput

0.500

High

229073

KLF16
Krueppel-like factor 16

1

6

High-throughput

0.500

High

229099

KLF15
Krueppel-like factor 15

1

6

High-throughput

0.500

High

228979

CASP3
Caspase-3

1

0

Small-scale

0.493

High

229006

FLII
Protein flightless-1 homolog

1

0

High-throughput

0.493

High

128644

MEN1
Menin

1

2

High-throughput

0.479

High

142735

NFIB
Nuclear factor 1 B-type

1

3

High-throughput

0.479

High

169837

AURKA
Aurora kinase A

1

5

High-throughput

0.479

High

174464

TRI66
Tripartite motif-containing protein 66

1

8

High-throughput

0.479

High

222557

PRC1
Protein regulator of cytokinesis 1

1

1

High-throughput

0.479

High

228932

PRKN
E3 ubiquitin-protein ligase parkin

1

3

High-throughput

0.479

High

228934

TAD2A
Transcriptional adapter 2-alpha

1

1

High-throughput

0.479

High

228935

RECQ4
ATP-dependent DNA helicase Q4

1

4

High-throughput

0.479

High

228936

TRI37
E3 ubiquitin-protein ligase TRIM37

1

8

High-throughput

0.479

High

228937

KI20A
Kinesin-like protein KIF20A

1

6

High-throughput

0.479

High

228939

BRD1
Bromodomain-containing protein 1

1

6

High-throughput

0.479

High

228940

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

1

High-throughput

0.479

High

228944

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

4

High-throughput

0.479

High

228945

MYCN
N-myc proto-oncogene protein

1

5

High-throughput

0.479

High

228947

HSPB1
Heat shock protein beta-1

1

2

Small-scale

0.479

High

228948

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

6

High-throughput

0.479

High

228949

NFIC
Nuclear factor 1 C-type

1

5

High-throughput

0.479

High

228954

ARAF
Serine/threonine-protein kinase A-Raf

1

4

High-throughput

0.479

High

228959

GATA1
Erythroid transcription factor

1

2

High-throughput

0.479

High

228961

CEBPB
CCAAT/enhancer-binding protein beta

1

3

High-throughput

0.479

High

228963

KAPCB
cAMP-dependent protein kinase catalytic subunit beta

1

3

Small-scale

0.479

High

228964

NR4A1
Nuclear receptor subfamily 4immunitygroup A member 1

1

9

Small-scale

0.479

High

228966

SP100
Nuclear autoantigen Sp-100

1

7

High-throughput

0.479

High

228967

GATA3
Trans-acting T-cell-specific transcription factor GATA-3

1

2

High-throughput

0.479

High

228969

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

228970

CCND2
G1/S-specific cyclin-D2

1

4

Small-scale

0.479

High

228974

BMI1
Polycomb complex protein BMI-1

1

6

High-throughput

0.479

High

228975

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.479

High

228977

BRCA1
Breast cancer type 1 susceptibility protein

1

6

High-throughput

0.479

High

228978

CCNF
Cyclin-F

1

1

High-throughput

0.479

High

228983

MECP2
Methyl-CpG-binding protein 2

1

3

High-throughput

0.479

High

228984

PLK1
Serine/threonine-protein kinase PLK1

1

4

High-throughput

0.479

High

228990

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.479

High

228992

H4
Histone H4

1

1

High-throughput

0.479

High

228996

VIGLN
Vigilin

1

3

High-throughput

0.479

High

228998

MECOM
Histone-lysine N-methyltransferase MECOM

1

2

High-throughput

0.479

High

228999

TF65
Transcription factor p65

1

2

High-throughput

0.479

High

229000

TLE3
Transducin-like enhancer protein 3

1

5

High-throughput

0.479

High

229003

EP300
Histone acetyltransferase p300

1

4

High-throughput

0.479

High

229004

NFIA
Nuclear factor 1 A-type

1

4

High-throughput

0.479

High

229005

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

5

High-throughput

0.479

High

229012

RBM39
RNA-binding protein 39

1

3

High-throughput

0.479

High

229013

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

5

High-throughput

0.479

High

229014

KIF14
Kinesin-like protein KIF14

1

2

High-throughput

0.479

High

229015

ZMY11
Zinc finger MYND domain-containing protein 11

1

10

Small-scale

0.479

High

229016

KS6A1
Ribosomal protein S6 kinase alpha-1

1

5

Small-scale

0.479

High

229019

E2F4
Transcription factor E2F4

1

2

High-throughput

0.479

High

229028

RNF43
E3 ubiquitin-protein ligase RNF43

1

1

High-throughput

0.479

High

229030

IFIX
Pyrin and HIN domain-containing protein 1

1

1

High-throughput

0.479

High

229033

BAKOR
Beclin 1-associated autophagy-related key regulator

1

1

High-throughput

0.479

High

229035

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.479

High

229036

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.479

High

229037

EMSY
BRCA2-interacting transcriptional repressor EMSY

1

2

High-throughput

0.479

High

229041

DHX40
Probable ATP-dependent RNA helicase DHX40

1

2

High-throughput

0.479

High

229044

SIR6
NAD-dependent protein deacylase sirtuin-6

1

1

High-throughput

0.479

High

229046

NUP35
Nucleoporin NUP35

1

1

High-throughput

0.479

High

229048

DNJB8
DnaJ homolog subfamily B member 8

1

1

High-throughput

0.479

High

229050

SP7
Transcription factor Sp7

1

6

High-throughput

0.479

High

229051

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

2

High-throughput

0.479

High

229052

DCAF4
DDB1- and CUL4-associated factor 4

1

1

High-throughput

0.479

High

229054

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

1

High-throughput

0.479

High

229060

ARMC5
Armadillo repeat-containing protein 5

1

2

High-throughput

0.479

High

229062

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

4

High-throughput

0.479

High

229063

CI072
Guanine nucleotide exchange factor C9orf72

1

1

High-throughput

0.479

High

229068

RING2
E3 ubiquitin-protein ligase RING2

1

10

High-throughput

0.479

High

229069

BARD1
BRCA1-associated RING domain protein 1

1

4

High-throughput

0.479

High

229070

ANM1
Protein arginine N-methyltransferase 1

1

4

High-throughput

0.479

High

229072

CECR2
Chromatin remodeling regulator CECR2

1

5

High-throughput

0.479

High

229075

TRI31
E3 ubiquitin-protein ligase TRIM31

1

5

High-throughput

0.479

High

229078

CCDC8
Coiled-coil domain-containing protein 8

1

1

High-throughput

0.479

High

229079

PKHA4
Pleckstrin homology domain-containing family A member 4

1

3

High-throughput

0.479

High

229081

PRD16
Histone-lysine N-methyltransferase PRDM16

1

2

High-throughput

0.479

High

229082

RC3H2
Roquin-2

1

4

High-throughput

0.479

High

229083

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

2

High-throughput

0.479

High

229084

ANLN
Anillin

1

1

High-throughput

0.479

High

229086

ASH1L
Histone-lysine N-methyltransferase ASH1L

1

1

Small-scale

0.479

High

229087

RNC
Ribonuclease 3

1

3

High-throughput

0.479

High

229088

DJC11
DnaJ homolog subfamily C member 11

1

2

High-throughput

0.479

High

229095

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

229097

ABC3B
DNA dC->dU-editing enzyme APOBEC-3B

1

3

Small-scale

0.479

High

229101

FBW1B
F-box/WD repeat-containing protein 11

1

4

High-throughput

0.479

High

229102

BRPF3
Bromodomain and PHD finger-containing protein 3

1

6

High-throughput

0.479

High

229104

FZR1
Fizzy-related protein homolog

1

4

High-throughput

0.479

High

229106

FBW1A
F-box/WD repeat-containing protein 1A

1

4

High-throughput

0.479

High

176011

KDM6B
Lysine-specific demethylase 6B

1

0

Small-scale

0.458

High

228953

SCHI1
Schwannomin-interacting protein 1

1

0

High-throughput

0.458

High

228958

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

228965

GCSP
Glycine dehydrogenase

1

0

High-throughput

0.458

High

228981

ARL4D
ADP-ribosylation factor-like protein 4D

1

0

High-throughput

0.458

High

229021

PTN21
Tyrosine-protein phosphatase non-receptor type 21

1

0

High-throughput

0.458

High

229022

PDS5A
Sister chromatid cohesion protein PDS5 homolog A

1

0

High-throughput

0.458

High

229024

CRY2
Cryptochrome-2

1

0

High-throughput

0.458

High

229029

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

229031

NIPBL
Nipped-B-like protein

1

0

High-throughput

0.458

High

229032

LMBRL
Protein LMBR1L

1

0

High-throughput

0.458

High

229038

DTX2
Probable E3 ubiquitin-protein ligase DTX2

1

0

High-throughput

0.458

High

229042

FA20C
Extracellular serine/threonine protein kinase FAM20C

1

0

High-throughput

0.458

High

229043

STAG2
Cohesin subunit SA-2

1

0

High-throughput

0.458

High

229047

TNIP2
TNFAIP3-interacting protein 2

1

0

High-throughput

0.458

High

229057

FGF11
Fibroblast growth factor 11

1

0

High-throughput

0.458

High

229059

FBX32
F-box only protein 32

1

0

High-throughput

0.458

High

229077

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

0

High-throughput

0.458

High

229089

ARL8B
ADP-ribosylation factor-like protein 8B

1

0

High-throughput

0.458

High

229094

LRWD1
Leucine-rich repeat and WD repeat-containing protein 1

1

0

Small-scale

0.458

High

229096

TES
Testin

1

0

High-throughput

0.458

High

229098

MKRN1
E3 ubiquitin-protein ligase makorin-1

1

0

Small-scale

0.458

High

229108

SCC4
MAU2 chromatid cohesion factor homolog

1

0

High-throughput

0.458

High

143370

E2F3
Transcription factor E2F3

1

2

Small-scale

0.445

High

228933

NCOR1
Nuclear receptor corepressor 1

1

3

Small-scale

0.445

High

228941

PAK4
Serine/threonine-protein kinase PAK 4

1

1

High-throughput

0.445

High

228994

YBOX1
Y-box-binding protein 1

1

3

Small-scale

0.445

High

229025

KLH22
Kelch-like protein 22

1

1

High-throughput

0.445

High

229027

A16L1
Autophagy-related protein 16-1

1

4

High-throughput

0.445

High

229034

NBEL2
Neurobeachin-like protein 2

1

3

High-throughput

0.445

High

229053

S39A7
Zinc transporter SLC39A7

1

1

High-throughput

0.445

High

229080

LN28A
Protein lin-28 homolog A

1

3

High-throughput

0.445

High

229091

WRP73
WD repeat-containing protein WRAP73

1

3

Small-scale

0.445

High

229049

TIP
T-cell immunomodulatory protein

1

1

High-throughput

0.437

High

229103

HECD1
E3 ubiquitin-protein ligase HECTD1

1

6

High-throughput

0.437

High

229093

SL9A2
Sodium/hydrogen exchanger 2

1

0

High-throughput

0.426

High

229023

CL16A
Protein CLEC16A

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025