HitPredict

Interactor 1: TRI50 (Q86XT4)
E3 ubiquitin-protein ligase TRIM50 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase TRIM50) (Tripartite motif-containing protein 50)
Gene: TRIM50

Interactor 2: UB2D4 (Q9Y2X8)
Ubiquitin-conjugating enzyme E2 D4 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme D4) (HBUCE1) (Ubiquitin carrier protein D4) (Ubiquitin-protein ligase D4)
Gene: UBE2D4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	1.00	0.845

Property	Details
Experiments	32296183, 21143188, unassigned1304
Identification Methods	two hybrid, validated two hybrid, two hybrid array, two hybrid prey pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	UQ_con~zf-RING_UBOX
Common GO terms	GO:0016567 - protein ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 487 Hs			1 147
+	Hs
		584907 RO52_HUMAN (1-473): 6.68e-148: 433: 26.72		UB2D1_HUMAN (1-147): 4.61e-83: 241: 91.84
+	Hs
		584923 RO52_HUMAN (1-473): 6.68e-148: 433: 26.72		UB2D2_HUMAN (1-147): 1.54e-82: 240: 93.20
+	Hs
		584916 RO52_HUMAN (1-473): 6.68e-148: 433: 26.72		UB2D3_HUMAN (1-147): 1.56e-81: 238: 91.84
+	Hs
		1336390 TRI39_HUMAN (7-474): 9.71e-142: 418: 27.09		UB2D4_HUMAN (1-147): 8.89e-84: 243: 100.00
+	Hs
		849453 TRI39_HUMAN (7-474): 9.71e-142: 418: 27.09		UB2D1_HUMAN (1-147): 4.61e-83: 241: 91.84
+	Hs
		919870 TRI39_HUMAN (7-474): 9.71e-142: 418: 27.09		UB2D2_HUMAN (1-147): 1.54e-82: 240: 93.20
+	Hs
		895921 TRI39_HUMAN (7-474): 9.71e-142: 418: 27.09		UB2D3_HUMAN (1-147): 1.56e-81: 238: 91.84
+	Hs
		584910 RO52_HUMAN (1-473): 6.68e-148: 433: 26.72		UB2E1_HUMAN (4-146): 4.67e-73: 218: 64.34
+	Hs
		849360 TRI50_HUMAN (1-487): 5.07e-137: 405: 100.00		UB2D1_HUMAN (1-147): 4.61e-83: 241: 91.84
+	Hs
		919773 TRI50_HUMAN (1-487): 5.07e-137: 405: 100.00		UB2D2_HUMAN (1-147): 1.54e-82: 240: 93.20
+	Hs
		895838 TRI50_HUMAN (1-487): 5.07e-137: 405: 100.00		UB2D3_HUMAN (1-147): 1.56e-81: 238: 91.84
+	Hs
		1297370 TRI39_HUMAN (7-474): 9.71e-142: 418: 27.09		UB2E2_HUMAN (4-146): 3.5e-75: 224: 64.34
+	Hs
		1282350 TRI39_HUMAN (7-474): 9.71e-142: 418: 27.09		UB2E3_HUMAN (4-146): 1.24e-74: 223: 64.34
+	Hs
		584918 RO52_HUMAN (1-473): 6.68e-148: 433: 26.72		UBE2N_HUMAN (4-147): 1.52e-69: 208: 46.53
+	Hs
		851889 TRI39_HUMAN (7-474): 9.71e-142: 418: 27.09		UB2E1_HUMAN (4-146): 4.67e-73: 218: 64.34
+	Hs
		1204902 TRI50_HUMAN (1-487): 5.07e-137: 405: 100.00		UB2E2_HUMAN (4-146): 3.5e-75: 224: 64.34
+	Hs
		1204900 TRI50_HUMAN (1-487): 5.07e-137: 405: 100.00		UB2E3_HUMAN (4-146): 1.24e-74: 223: 64.34
+	Hs
		896547 TRI39_HUMAN (7-474): 9.71e-142: 418: 27.09		UBE2N_HUMAN (4-147): 1.52e-69: 208: 46.53
+	Hs
		851837 TRI50_HUMAN (1-487): 5.07e-137: 405: 100.00		UB2E1_HUMAN (4-146): 4.67e-73: 218: 64.34
+	Hs
		896483 TRI50_HUMAN (1-487): 5.07e-137: 405: 100.00		UBE2N_HUMAN (4-147): 1.52e-69: 208: 46.53