HitPredict

Interactor 1: MD12L (Q86YW9)
Mediator of RNA polymerase II transcription subunit 12-like protein (Mediator complex subunit 12-like protein) (Thyroid hormone receptor-associated-like protein) (Trinucleotide repeat-containing gene 11 protein-like)
Gene: MED12L

Interactor 2: MED12 (Q93074)
Mediator of RNA polymerase II transcription subunit 12 (Activator-recruited cofactor 240 kDa component) (ARC240) (CAG repeat protein 45) (Mediator complex subunit 12) (OPA-containing protein) (Thyroid hormone receptor-associated protein complex 230 kDa component) (Trap230) (Trinucleotide repeat-containing gene 11 protein)
Gene: MED12

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	24981860
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003713 - transcription coactivator activity GO:0008013 - beta-catenin binding GO:0016592 - mediator complex GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 2145 Hs			1 2177
+	Zm
		43541 A0A1D6PM30_MAIZE (7-366): 1.5e-116: 415: 21.64		A0A1D6PM30_MAIZE (7-627): 0: 631: 17.66
+	Hs
		1057773 NCOA6_HUMAN (1589-2051): 1.53e-09: 65.7: 9.29		KMT2C_HUMAN (1619-2174): 8.59e-16: 86.5: 10.80
+	Hs
		1167113 MCAF1_HUMAN (1570-2036): 1.45e-13: 78.8: 7.55		CBP_HUMAN (1582-2176): 2.69e-11: 71.5: 13.45
+	Hs
		1262706 ATX2L_HUMAN (1591-2142): 1.97e-13: 78.4: 10.93		ATX2_HUMAN (1645-2176): 2.64e-11: 71.5: 9.32
+	Hs
		1244276 ATX2L_HUMAN (1591-2142): 1.97e-13: 78.4: 10.93		ARI1B_HUMAN (1839-2172): 5.1e-10: 67.3: 14.20
+	Hs
		998940 EP300_HUMAN (1799-2145): 2.26e-11: 71.9: 11.05		CBP_HUMAN (1582-2176): 2.69e-11: 71.5: 13.45
+	Hs
		300511 NFAT5_HUMAN (1561-2133): 2.51e-09: 64.9: 11.07		NFAT5_HUMAN (1583-2168): 1.04e-12: 76.1: 12.29
+	Mm
		70879 EP300_MOUSE (1808-2143): 1.67e-11: 72.2: 10.95		F8VPR5_MOUSE (1658-2031): 7.3e-10: 66.9: 11.66
+	Hs
		998981 EP300_HUMAN (1799-2145): 2.26e-11: 71.9: 11.05		ZN469_HUMAN (1786-2166): 9.37e-10: 66.5: 10.12
+	Hs
		998713 EP300_HUMAN (1799-2145): 2.26e-11: 71.9: 11.05		NCOA6_HUMAN (1716-2173): 1.71e-09: 65.7: 11.91
+	Hs
		1057781 NCOA6_HUMAN (1589-2051): 1.53e-09: 65.7: 9.29		CBP_HUMAN (1582-2176): 2.69e-11: 71.5: 13.45
+	Hs
		256791 T22D2_HUMAN (1893-2141): 1.99e-09: 64.9: 13.46		SC31A_HUMAN (1897-2176): 1.29e-11: 72.3: 11.54
+	Mm
		1351630 PCLO_MOUSE (1585-2082): 4.74e-10: 67.6: 7.25		PCLO_MOUSE (1546-2153): 1.3e-09: 66.1: 10.38
+	Mm
		1207212 KMT2C_MOUSE (1617-2126): 1.08e-09: 66.5: 9.23		NCOA6_MOUSE (1782-2166): 9.03e-10: 66.5: 13.89
+	Dm
		113976 M9PB30_DROME (1578-2136): 4.02e-09: 64.5: 8.83		M9PB30_DROME (1590-2174): 5.73e-10: 67.3: 7.06
+	Hs
		1057757 NCOA6_HUMAN (1589-2051): 1.53e-09: 65.7: 9.29		NCOA6_HUMAN (1716-2173): 1.71e-09: 65.7: 11.91
+	Sp
		1013617 PAN1_SCHPO (1786-2144): 1.83e-09: 65.7: 9.42		PAN1_SCHPO (1678-2175): 4.67e-09: 64.2: 11.02
+	Mm
		99853 F8WI37_MOUSE (1617-2126): 1.06e-09: 66.5: 9.23		F6M2J9_MOUSE (1841-2175): 8.77e-09: 63: 13.27