Protein: OTUD3
OTU domain-containing protein 3 (EC 3.4.19.12)

Gene: OTUD3
Organism: Homo sapiens
Interactions: 60
UniProt ID: Q5T2D3

Gene Ontology (top 5):
GO:0004843 - cysteine-type deubiquitinase activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006508 - proteolysis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

508106

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

4

11

Small-scale

0.888

High

1212116

OTUD3
OTU domain-containing protein 3

1

7

Small-scale

0.724

High

951708

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

2

3

Small-scale

0.646

High

1032334

OTUD4
OTU domain-containing protein 4

1

7

Small-scale

0.618

High

1212130

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.618

High

1212129

DHB14
L-fucose dehydrogenase

2

1

High-throughput

0.606

High

1212122

CGAS
Cyclic GMP-AMP synthase

1

1

Small-scale

0.589

High

1212126

ITFG2
KICSTOR complex protein ITFG2

2

0

Small-scale

0.585

High

413983

P53
Cellular tumor antigen p53

1

3

Small-scale

0.561

High

535158

BIP
Endoplasmic reticulum chaperone BiP

1

4

Small-scale

0.561

High

1041759

PPARD
Peroxisome proliferator-activated receptor delta

1

4

Small-scale

0.561

High

870960

IREB2
Iron-responsive element-binding protein 2

1

0

Small-scale

0.537

High

1212131

CHIP
E3 ubiquitin-protein ligase CHIP

1

0

Small-scale

0.537

High

70941

GNAT3
Guanine nucleotide-binding protein G(t) subunit alpha-3

1

3

High-throughput

0.536

High

374662

RASH
GTPase HRas

1

1

High-throughput

0.536

High

716030

GNA11
Guanine nucleotide-binding protein subunit alpha-11

1

3

High-throughput

0.536

High

984149

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

1

High-throughput

0.536

High

1125885

GNA13
Guanine nucleotide-binding protein subunit alpha-13

1

3

High-throughput

0.536

High

1129084

PLSI
Plastin-1

1

1

High-throughput

0.536

High

1212120

MIB1
E3 ubiquitin-protein ligase MIB1

1

1

High-throughput

0.536

High

1212124

KBTB7
Kelch repeat and BTB domain-containing protein 7

1

1

High-throughput

0.536

High

291661

XRP2
Protein XRP2

1

0

High-throughput

0.513

High

946136

MLF1
Myeloid leukemia factor 1

1

0

High-throughput

0.513

High

1128609

ZN268
Zinc finger protein 268

1

0

High-throughput

0.513

High

1212117

KPRP
Keratinocyte proline-rich protein

1

0

High-throughput

0.513

High

186853

FOXN1
Forkhead box protein N1

1

1

Small-scale

0.501

High

604774

HXB8
Homeobox protein Hox-B8

1

1

Small-scale

0.501

High

775855

HNF1B
Hepatocyte nuclear factor 1-beta

1

1

Small-scale

0.501

High

1212118

BAKOR
Beclin 1-associated autophagy-related key regulator

1

1

High-throughput

0.501

High

333898

SIX3
Homeobox protein SIX3

1

0

Small-scale

0.480

High

995970

UB2L3
Ubiquitin-conjugating enzyme E2 L3

1

0

Small-scale

0.480

High

1212123

BHE22
Class E basic helix-loop-helix protein 22

1

0

Small-scale

0.480

High

1212132

FOXA2
Hepatocyte nuclear factor 3-beta

1

0

Small-scale

0.480

High

160522

IRS4
Insulin receptor substrate 4

1

2

Small-scale

0.479

High

170183

AURKA
Aurora kinase A

1

11

Small-scale

0.479

High

291024

ADAP1
Arf-GAP with dual PH domain-containing protein 1

1

2

High-throughput

0.479

High

316884

MTA2
Metastasis-associated protein MTA2

1

2

Small-scale

0.479

High

567424

TCTP
Translationally-controlled tumor protein

1

1

Small-scale

0.479

High

620408

NUCL
Nucleolin

1

5

Small-scale

0.479

High

688259

TTP
mRNA decay activator protein ZFP36

1

4

Small-scale

0.479

High

772842

MYH9
Myosin-9

1

3

Small-scale

0.479

High

994588

YBOX1
Y-box-binding protein 1

1

5

Small-scale

0.479

High

1045375

TF65
Transcription factor p65

1

2

High-throughput

0.479

High

1062499

DHX9
ATP-dependent RNA helicase A

1

6

Small-scale

0.479

High

1093247

FLII
Protein flightless-1 homolog

1

2

Small-scale

0.479

High

1099108

SRSF5
Serine/arginine-rich splicing factor 5

1

8

Small-scale

0.479

High

1107806

SQSTM
Sequestosome-1

1

2

High-throughput

0.479

High

1124615

SRC8
Src substrate cortactin

1

2

High-throughput

0.479

High

1125127

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

8

Small-scale

0.479

High

1212125

KAT6A
Histone acetyltransferase KAT6A

1

2

Small-scale

0.479

High

224725

ACTN4
Alpha-actinin-4

1

0

Small-scale

0.458

High

662070

DGKA
Diacylglycerol kinase alpha

1

0

High-throughput

0.458

High

1204360

SGO1
Shugoshin 1

1

0

High-throughput

0.458

High

1212127

INT12
Integrator complex subunit 12

1

0

High-throughput

0.458

High

1212133

KPTN
KICSTOR complex protein kaptin

2

0

Small-scale

0.324

High

893572

GBG10

1

0

High-throughput

0.279

Low

1212119

CAPS2
Calcium-dependent secretion activator 2

1

0

High-throughput

0.249

Low

1212121

MET25
Probable methyltransferase-like protein 25

1

0

High-throughput

0.249

Low

1212128

KICS2
KICSTOR subunit 2

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025