HitPredict

Interactor 1: Q8IP45 (Q8IP45)
Cullin 3, isoform F (FI19425p1)
Gene: Cul3

Interactor 2: RDX (Q9VFP2)
Protein roadkill (Hh-induced MATH and BTB domain-containing protein)
Gene: RDX

Species: Drosophila melanogaster

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.82 1.00 0.907

The method score is based on:

Property Details
Experiments 23747190, 26263855, 20691177, 16740475, 17880263
Identification Methods affinity chromatography technology, two hybrid
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains BTB~Cullin
Common GO terms GO:0016567 - protein ubiquitination
GO:0031463 - Cul3-RING ubiquitin ligase complex
GO:0031625 - ubiquitin protein ligase binding
GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045879 - negative regulation of smoothened signaling pathway
and 1 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 934
Dm

1 829
+ Dm
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+ Hs
+ Hs
+ Hs
+ Rn
+ Hs
+ Mm
+ Dm
+ Hs
+ Hs
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+ Hs
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+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024