Protein: FILA2
Filaggrin-2 (FLG-2) (Intermediate filament-associated and psoriasis-susceptibility protein) (Ifapsoriasin)

Gene: FILA2, FLG2
Organism: Homo sapiens
Interactions: 135
UniProt ID: Q5D862

Gene Ontology (top 5):
GO:0001533 - cornified envelope
GO:0005198 - structural molecule activity
GO:0005509 - calcium ion binding
GO:0005576 - extracellular region
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

563868

CFTR
Cystic fibrosis transmembrane conductance regulator

2

8

High-throughput

0.628

High

1204009

FGRL1
Fibroblast growth factor receptor-like 1

1

5

High-throughput

0.618

High

413967

P53
Cellular tumor antigen p53

1

14

Small-scale

0.618

High

456749

ANXA2
Annexin A2

1

16

High-throughput

0.618

High

635603

FILA
Filaggrin

1

19

High-throughput

0.618

High

1204007

HORN
Hornerin

1

20

High-throughput

0.618

High

1204040

PD1L1
Programmed cell death 1 ligand 1

1

5

High-throughput

0.553

High

529926

TAU
Microtubule-associated protein tau

2

16

Small-scale

0.552

High

391622

FRIH
Ferritin heavy chain

1

3

High-throughput

0.536

High

443396

CDK1
Cyclin-dependent kinase 1

1

10

High-throughput

0.536

High

640912

VDAC1
Non-selective voltage-gated ion channel VDAC1

1

1

High-throughput

0.536

High

658714

JAK1
Tyrosine-protein kinase JAK1

1

11

High-throughput

0.536

High

666842

CCNC
Cyclin-C

1

4

High-throughput

0.536

High

1099694

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

1

1

High-throughput

0.536

High

1136440

FL2D
Pre-mRNA-splicing regulator WTAP

1

1

High-throughput

0.536

High

1204003

MTA70
N(6)-adenosine-methyltransferase catalytic subunit METTL3

1

4

High-throughput

0.536

High

1204016

CSN5
COP9 signalosome complex subunit 5

1

6

High-throughput

0.536

High

1204022

GMCL1
Germ cell-less protein-like 1

1

8

High-throughput

0.536

High

1204032

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

4

High-throughput

0.536

High

830860

CCNF
Cyclin-F

1

4

High-throughput

0.515

High

1204020

DCNL1
DCN1-like protein 1

1

0

High-throughput

0.513

High

461567

HS90A
Heat shock protein HSP 90-alpha

1

4

Small-scale

0.501

High

1204017

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

8

High-throughput

0.501

High

292649

RENR
Renin receptor

1

3

High-throughput

0.489

High

773898

SOAT1
Sterol O-acyltransferase 1

1

1

High-throughput

0.489

High

876337

PTSS1
Phosphatidylserine synthase 1

1

4

High-throughput

0.489

High

943065

STX17
Syntaxin-17

1

2

High-throughput

0.489

High

1112869

CUL2
Cullin-2

1

20

High-throughput

0.489

High

1140078

IQCB1
IQ calmodulin-binding motif-containing protein 1

1

2

High-throughput

0.489

High

1204025

SH23A
SH2 domain-containing protein 3A

1

14

High-throughput

0.489

High

1204034

TSSP
Thymus-specific serine protease

1

1

High-throughput

0.489

High

1204037

TB22B
TBC1 domain family member 22B

1

4

High-throughput

0.489

High

65377

DPRX
Divergent paired-related homeobox

1

15

High-throughput

0.479

High

141519

DDX3X
ATP-dependent RNA helicase DDX3X

1

8

Small-scale

0.479

High

241889

PRKN
E3 ubiquitin-protein ligase parkin

1

6

High-throughput

0.479

High

247951

NUPR1
Nuclear protein 1

1

2

High-throughput

0.479

High

277294

PITX3
Pituitary homeobox 3

1

13

Small-scale

0.479

High

282472

KTNA1
Katanin p60 ATPase-containing subunit A1

1

10

High-throughput

0.479

High

293795

CD123
Translation initiation factor eIF2 assembly protein

1

8

High-throughput

0.479

High

302547

RNF8
E3 ubiquitin-protein ligase RNF8

1

17

High-throughput

0.479

High

319817

UFL1
E3 UFM1-protein ligase 1

1

2

High-throughput

0.479

High

396259

ESR1
Estrogen receptor

1

20

High-throughput

0.479

High

400945

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

12

High-throughput

0.479

High

406253

MYCN
N-myc proto-oncogene protein

1

19

High-throughput

0.479

High

482494

F16P1
Fructose-1,6-bisphosphatase 1

1

2

High-throughput

0.479

High

485187

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

6

High-throughput

0.479

High

487389

PARP1
Poly [ADP-ribose] polymerase 1

1

10

High-throughput

0.479

High

488492

UCHL1
Ubiquitin carboxyl-terminal hydrolase isozyme L1

1

4

Small-scale

0.479

High

538406

EGR2
E3 SUMO-protein ligase EGR2

1

9

High-throughput

0.479

High

577783

PLAK
Junction plakoglobin

1

13

High-throughput

0.479

High

587485

TFE2
Transcription factor E2-alpha

1

1

High-throughput

0.479

High

587686

DESP
Desmoplakin

1

4

High-throughput

0.479

High

623373

RO52
E3 ubiquitin-protein ligase TRIM21

1

10

High-throughput

0.479

High

629905

BTF3
Transcription factor BTF3

1

2

High-throughput

0.479

High

667899

CDK2
Cyclin-dependent kinase 2

1

10

High-throughput

0.479

High

729568

CASPE
Caspase-14

1

4

High-throughput

0.479

High

848267

MAGA3
Melanoma-associated antigen 3

1

5

Small-scale

0.479

High

862198

YAP1
Transcriptional coactivator YAP1

1

12

High-throughput

0.479

High

904808

MECP2
Methyl-CpG-binding protein 2

1

8

High-throughput

0.479

High

908835

NEK2
Serine/threonine-protein kinase Nek2

1

9

Small-scale

0.479

High

970617

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

6

High-throughput

0.479

High

1015038

ARF5
ADP-ribosylation factor 5

1

3

High-throughput

0.479

High

1024614

VIGLN
Vigilin

1

3

High-throughput

0.479

High

1035675

KIF23
Kinesin-like protein KIF23

1

12

High-throughput

0.479

High

1036739

DSG1
Desmoglein-1

1

6

High-throughput

0.479

High

1047426

K1C17
Keratin, type I cytoskeletal 17

1

4

High-throughput

0.479

High

1062242

TGM3
Protein-glutamine gamma-glutamyltransferase E

1

5

High-throughput

0.479

High

1064435

DSC1
Desmocollin-1

1

4

High-throughput

0.479

High

1088385

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

9

High-throughput

0.479

High

1114868

CUL4A
Cullin-4A

1

20

High-throughput

0.479

High

1117945

PKP1
Plakophilin-1

1

10

High-throughput

0.479

High

1118051

DX39B
Spliceosome RNA helicase DDX39B

1

8

High-throughput

0.479

High

1132744

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

9

High-throughput

0.479

High

1138287

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

2

High-throughput

0.479

High

1155437

EZH2
Histone-lysine N-methyltransferase EZH2

1

15

High-throughput

0.479

High

1194134

LARP7
La-related protein 7

1

5

High-throughput

0.479

High

1203993

KPRP
Keratinocyte proline-rich protein

1

2

High-throughput

0.479

High

1203996

OTU1
Ubiquitin thioesterase OTU1

1

2

High-throughput

0.479

High

1203997

VIR
Protein virilizer homolog

1

4

High-throughput

0.479

High

1204001

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.479

High

1204006

GOLI
E3 ubiquitin-protein ligase RNF130

1

3

High-throughput

0.479

High

1204014

NALP7
NACHT, LRR and PYD domains-containing protein 7

1

7

High-throughput

0.479

High

1204019

DCPS
m7GpppX diphosphatase

1

2

High-throughput

0.479

High

1204023

SPB12
Serpin B12

1

9

High-throughput

0.479

High

1204024

CIC
Protein capicua homolog

1

19

High-throughput

0.479

High

1204026

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

20

High-throughput

0.479

High

1204027

ACE2
Angiotensin-converting enzyme 2

1

5

High-throughput

0.479

High

1204029

DDX24
ATP-dependent RNA helicase DDX24

1

8

High-throughput

0.479

High

1204036

FBX6
F-box only protein 6

1

5

High-throughput

0.479

High

1204038

ARL8B
ADP-ribosylation factor-like protein 8B

1

4

High-throughput

0.479

High

1204039

RNF12
E3 ubiquitin-protein ligase RLIM

1

7

High-throughput

0.479

High

1204041

ZRAN1
Ubiquitin thioesterase ZRANB1

1

18

High-throughput

0.479

High

1204045

FZR1
Fizzy-related protein homolog

1

11

High-throughput

0.479

High

1204046

FBW1A
F-box/WD repeat-containing protein 1A

1

11

High-throughput

0.479

High

1204048

UBP20
Ubiquitin carboxyl-terminal hydrolase 20

1

12

Small-scale

0.479

High

390604

TFR1
Transferrin receptor protein 1

1

0

High-throughput

0.458

High

423663

ARGI1
Arginase-1

1

0

High-throughput

0.458

High

1203995

ARM12
Armadillo repeat-containing protein 12

1

0

Small-scale

0.458

High

1203998

CDC73
Parafibromin

1

0

High-throughput

0.458

High

1203999

PRP8
Pre-mRNA-processing-splicing factor 8

1

0

High-throughput

0.458

High

1204002

WAPL
Wings apart-like protein homolog

1

0

High-throughput

0.458

High

1204013

STAG1
Cohesin subunit SA-1

1

0

High-throughput

0.458

High

1118715

KLF5
Krueppel-like factor 5

1

19

High-throughput

0.457

High

934709

TERA
Transitional endoplasmic reticulum ATPase

1

7

High-throughput

0.445

High

952200

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

17

High-throughput

0.445

High

1063782

LG3BP
Galectin-3-binding protein

1

11

High-throughput

0.445

High

1203992

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

7

High-throughput

0.445

High

1204008

SULF2
Extracellular sulfatase Sulf-2

1

3

High-throughput

0.445

High

1204010

RYBP
RING1 and YY1-binding protein

1

4

High-throughput

0.445

High

1204015

ESR2
Estrogen receptor beta

1

20

High-throughput

0.445

High

1204042

AGO1
Protein argonaute-1

1

2

High-throughput

0.445

High

1204043

PADI1
Protein-arginine deiminase type-1

1

4

Small-scale

0.445

High

1204044

PADI3
Protein-arginine deiminase type-3

1

4

Small-scale

0.445

High

1204047

PADI2
Protein-arginine deiminase type-2

1

4

Small-scale

0.445

High

1137751

TNIP1
TNFAIP3-interacting protein 1

1

20

High-throughput

0.437

High

1204000

RICTR
Rapamycin-insensitive companion of mTOR

1

3

High-throughput

0.437

High

1204018

ZUP1
Zinc finger-containing ubiquitin peptidase 1

1

5

Small-scale

0.437

High

1204033

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

7

High-throughput

0.437

High

1204035

ANLN
Anillin

1

7

High-throughput

0.437

High

1204011

ZN808
Zinc finger protein 808

1

0

High-throughput

0.426

High

1063

SIM26
Small integral membrane protein 26

1

1

High-throughput

0.407

High

653362

HEMH
Ferrochelatase, mitochondrial

1

2

High-throughput

0.407

High

841188

CNDD3
Condensin-2 complex subunit D3

1

1

High-throughput

0.407

High

1204012

PI4P1
Putative inactive phosphatidylinositol 4-kinase alpha-like protein P1

1

6

High-throughput

0.407

High

1204021

S39AD
Zinc transporter ZIP13

1

3

High-throughput

0.407

High

1204028

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

17

High-throughput

0.407

High

1204030

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

17

High-throughput

0.407

High

1204031

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

1

17

High-throughput

0.407

High

1204049

S4A4
Electrogenic sodium bicarbonate cotransporter 1

1

1

High-throughput

0.407

High

1204004

AROS
Active regulator of SIRT1

1

0

High-throughput

0.279

Low

276140

NIPS2
Protein NipSnap homolog 2

1

0

Small-scale

0.249

Low

993079

KCNJ2
Inward rectifier potassium channel 2

1

0

Small-scale

0.249

Low

1135891

FAKD3
FAST kinase domain-containing protein 3, mitochondrial

1

0

High-throughput

0.249

Low

1203994

KPLCE
Protein KPLCE

1

0

High-throughput

0.249

Low

1204005

DYR2
Dihydrofolate reductase 2, mitochondrial

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025