Protein: HORN
Hornerin

Gene: HORN, HRNR
Organism: Homo sapiens
Interactions: 150
UniProt ID: Q86YZ3

Gene Ontology (top 5):
GO:0001533 - cornified envelope
GO:0005509 - calcium ion binding
GO:0005576 - extracellular region
GO:0005634 - nucleus
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

414148

P53
Cellular tumor antigen p53

1

18

Small-scale

0.618

High

1204007

FILA2
Filaggrin-2

1

20

High-throughput

0.618

High

242191

PRKN
E3 ubiquitin-protein ligase parkin

2

5

High-throughput

0.584

High

990454

1433Z
14-3-3 protein zeta/delta

2

3

Small-scale

0.584

High

1026452

HSF1
Heat shock factor protein 1

2

6

High-throughput

0.584

High

1118084

DX39B
Spliceosome RNA helicase DDX39B

2

8

Small-scale

0.584

High

1295707

PP16B
Protein phosphatase 1 regulatory inhibitor subunit 16B

1

5

High-throughput

0.554

High

133868

FOXN3
Forkhead box protein N3

1

5

High-throughput

0.536

High

361295

SODC
Superoxide dismutase [Cu-Zn]

1

1

High-throughput

0.536

High

370332

CYTA
Cystatin-A

1

2

High-throughput

0.536

High

443428

CDK1
Cyclin-dependent kinase 1

1

10

High-throughput

0.536

High

471119

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

2

High-throughput

0.536

High

564019

CFTR
Cystic fibrosis transmembrane conductance regulator

1

9

High-throughput

0.536

High

640944

VDAC1
Non-selective voltage-gated ion channel VDAC1

1

1

High-throughput

0.536

High

909078

NEK4
Serine/threonine-protein kinase Nek4

1

13

High-throughput

0.536

High

1054123

BTK
Tyrosine-protein kinase BTK

1

1

Small-scale

0.536

High

1136463

FL2D
Pre-mRNA-splicing regulator WTAP

1

1

High-throughput

0.536

High

1140102

IQCB1
IQ calmodulin-binding motif-containing protein 1

1

2

High-throughput

0.536

High

1287851

MTA70
N(6)-adenosine-methyltransferase catalytic subunit METTL3

1

4

High-throughput

0.536

High

1295693

STYX
Serine/threonine/tyrosine-interacting protein

1

1

Small-scale

0.536

High

1295695

CSN5
COP9 signalosome complex subunit 5

1

6

High-throughput

0.536

High

1295721

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

4

High-throughput

0.536

High

1295723

ANLN
Anillin

2

5

High-throughput

0.533

High

487495

PARP1
Poly [ADP-ribose] polymerase 1

1

8

High-throughput

0.515

High

1161791

CDKN3
Cyclin-dependent kinase inhibitor 3

1

0

High-throughput

0.513

High

1295708

PARK7
Parkinson disease protein 7

1

0

High-throughput

0.513

High

461673

HS90A
Heat shock protein HSP 90-alpha

1

5

Small-scale

0.501

High

508240

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

2

High-throughput

0.501

High

1295696

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

6

High-throughput

0.501

High

1295734

GSTK1
Glutathione S-transferase kappa 1

1

0

High-throughput

0.493

High

773919

SOAT1
Sterol O-acyltransferase 1

1

1

High-throughput

0.489

High

1112906

CUL2
Cullin-2

1

20

High-throughput

0.489

High

1295725

POTE1
Protection of telomeres protein 1

1

1

High-throughput

0.489

High

65380

DPRX
Divergent paired-related homeobox

1

10

High-throughput

0.479

High

141560

DDX3X
ATP-dependent RNA helicase DDX3X

1

8

Small-scale

0.479

High

219084

RA51C
DNA repair protein RAD51 homolog 3

1

2

High-throughput

0.479

High

223163

PRC1
Protein regulator of cytokinesis 1

1

4

High-throughput

0.479

High

277296

PITX3
Pituitary homeobox 3

1

9

Small-scale

0.479

High

293964

CD123
Translation initiation factor eIF2 assembly protein

1

8

High-throughput

0.479

High

302574

RNF8
E3 ubiquitin-protein ligase RNF8

1

16

High-throughput

0.479

High

323472

TRI37
E3 ubiquitin-protein ligase TRIM37

1

20

High-throughput

0.479

High

324971

HEXI1
Protein HEXIM1

1

2

High-throughput

0.479

High

363528

EGFR
Epidermal growth factor receptor

1

20

High-throughput

0.479

High

372488

MYC
Myc proto-oncogene protein

1

18

High-throughput

0.479

High

396454

ESR1
Estrogen receptor

1

20

High-throughput

0.479

High

401096

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

13

High-throughput

0.479

High

406356

MYCN
N-myc proto-oncogene protein

1

18

High-throughput

0.479

High

482508

F16P1
Fructose-1,6-bisphosphatase 1

1

2

High-throughput

0.479

High

485244

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

5

High-throughput

0.479

High

488512

UCHL1
Ubiquitin carboxyl-terminal hydrolase isozyme L1

1

5

Small-scale

0.479

High

520185

ANDR
Androgen receptor

1

20

High-throughput

0.479

High

521387

ARAF
Serine/threonine-protein kinase A-Raf

1

13

High-throughput

0.479

High

577815

PLAK
Junction plakoglobin

1

9

High-throughput

0.479

High

584657

HIS3
Histatin-3

1

2

Small-scale

0.479

High

587726

DESP
Desmoplakin

1

4

High-throughput

0.479

High

609733

LEG3
Galectin-3

1

5

Small-scale

0.479

High

623418

RO52
E3 ubiquitin-protein ligase TRIM21

1

9

High-throughput

0.479

High

629948

BTF3
Transcription factor BTF3

1

3

High-throughput

0.479

High

635271

EFNA1
Ephrin-A1

1

2

High-throughput

0.479

High

667925

CDK2
Cyclin-dependent kinase 2

1

10

High-throughput

0.479

High

783319

TRI23
E3 ubiquitin-protein ligase TRIM23

1

4

High-throughput

0.479

High

831022

CCNF
Cyclin-F

1

4

High-throughput

0.479

High

862274

YAP1
Transcriptional coactivator YAP1

1

8

High-throughput

0.479

High

886291

ARL4D
ADP-ribosylation factor-like protein 4D

1

7

High-throughput

0.479

High

888172

MCM2
DNA replication licensing factor MCM2

1

8

High-throughput

0.479

High

904898

MECP2
Methyl-CpG-binding protein 2

1

8

High-throughput

0.479

High

929990

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

3

Small-scale

0.479

High

934826

TERA
Transitional endoplasmic reticulum ATPase

1

6

Small-scale

0.479

High

947220

NLRP6
NACHT, LRR and PYD domains-containing protein 6

1

7

High-throughput

0.479

High

970735

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

7

High-throughput

0.479

High

1014919

ARF1
ADP-ribosylation factor 1

1

3

High-throughput

0.479

High

1015056

ARF5
ADP-ribosylation factor 5

1

3

High-throughput

0.479

High

1028270

MDM2
E3 ubiquitin-protein ligase Mdm2

1

9

Small-scale

0.479

High

1030474

FABP5
Fatty acid-binding protein 5

1

1

High-throughput

0.479

High

1033055

EWS
RNA-binding protein EWS

1

15

High-throughput

0.479

High

1035752

KIF23
Kinesin-like protein KIF23

1

11

High-throughput

0.479

High

1036763

DSG1
Desmoglein-1

1

5

High-throughput

0.479

High

1047444

K1C17
Keratin, type I cytoskeletal 17

1

3

High-throughput

0.479

High

1088432

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

11

High-throughput

0.479

High

1114923

CUL4A
Cullin-4A

1

20

High-throughput

0.479

High

1115786

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

11

High-throughput

0.479

High

1132808

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

11

High-throughput

0.479

High

1137099

SART3
Spliceosome associated factor 3, U4/U6 recycling protein

1

2

High-throughput

0.479

High

1194201

LARP7
La-related protein 7

1

5

High-throughput

0.479

High

1213770

KPRP
Keratinocyte proline-rich protein

1

1

High-throughput

0.479

High

1218596

OTU1
Ubiquitin thioesterase OTU1

1

2

High-throughput

0.479

High

1219112

KHDR2
KH domain-containing, RNA-binding, signal transduction-associated protein 2

1

1

High-throughput

0.479

High

1220621

RN123
E3 ubiquitin-protein ligase RNF123

1

7

High-throughput

0.479

High

1254503

TRI67
Tripartite motif-containing protein 67

1

19

High-throughput

0.479

High

1294153

CEP57
Centrosomal protein of 57 kDa

1

3

High-throughput

0.479

High

1295688

RHG24
Rho GTPase-activating protein 24

1

11

High-throughput

0.479

High

1295691

SERB1
SERPINE1 mRNA-binding protein 1

1

1

High-throughput

0.479

High

1295694

HDAC2
Histone deacetylase 2

1

9

High-throughput

0.479

High

1295699

ARMC5
Armadillo repeat-containing protein 5

1

6

High-throughput

0.479

High

1295701

AURKB
Aurora kinase B

1

10

High-throughput

0.479

High

1295705

SPB12
Serpin B12

1

8

High-throughput

0.479

High

1295706

CIC
Protein capicua homolog

1

20

High-throughput

0.479

High

1295709

NECD
Necdin

1

5

High-throughput

0.479

High

1295710

ANM1
Protein arginine N-methyltransferase 1

1

3

Small-scale

0.479

High

1295712

ACE2
Angiotensin-converting enzyme 2

1

4

High-throughput

0.479

High

1295713

TRI55
Tripartite motif-containing protein 55

1

20

High-throughput

0.479

High

1295714

TRIM6
Tripartite motif-containing protein 6

1

9

Small-scale

0.479

High

1295715

DDX24
ATP-dependent RNA helicase DDX24

1

8

High-throughput

0.479

High

1295716

PRD14
PR domain zinc finger protein 14

1

5

Small-scale

0.479

High

1295717

CCDC8
Coiled-coil domain-containing protein 8

1

1

High-throughput

0.479

High

1295718

TXNIP
Thioredoxin-interacting protein

1

12

Small-scale

0.479

High

1295719

CHM4B
Charged multivesicular body protein 4b

1

8

High-throughput

0.479

High

1295720

SENP2
Sentrin-specific protease 2

1

4

Small-scale

0.479

High

1295722

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

6

High-throughput

0.479

High

1295724

FBX6
F-box only protein 6

1

3

High-throughput

0.479

High

1295726

RNF12
E3 ubiquitin-protein ligase RLIM

1

7

High-throughput

0.479

High

1295727

HDAC6
Protein deacetylase HDAC6

1

12

High-throughput

0.479

High

1295728

ZRAN1
Ubiquitin thioesterase ZRANB1

1

15

High-throughput

0.479

High

1295729

UBP25
Ubiquitin carboxyl-terminal hydrolase 25

1

8

Small-scale

0.479

High

1295732

FBW1A
F-box/WD repeat-containing protein 1A

1

6

High-throughput

0.479

High

1295733

UBP20
Ubiquitin carboxyl-terminal hydrolase 20

1

13

Small-scale

0.479

High

1295735

RNF11
RING finger protein 11

1

6

Small-scale

0.479

High

1295698

PINX1
PIN2/TERF1-interacting telomerase inhibitor 1

1

1

High-throughput

0.470

High

257477

PAGE4
P antigen family member 4

1

0

High-throughput

0.458

High

646882

PUR6
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

1

0

High-throughput

0.458

High

1096583

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

1

0

High-throughput

0.458

High

1271723

MEPCE
7SK snRNA methylphosphate capping enzyme

1

0

High-throughput

0.458

High

1295731

FAF1
FAS-associated factor 1

1

0

High-throughput

0.458

High

1295711

RNF26
E3 ubiquitin-protein ligase RNF26

1

3

Small-scale

0.457

High

1118730

KLF5
Krueppel-like factor 5

1

12

High-throughput

0.457

High

530043

TAU
Microtubule-associated protein tau

1

19

High-throughput

0.445

High

1032358

OTUD4
OTU domain-containing protein 4

1

4

High-throughput

0.445

High

1063803

LG3BP
Galectin-3-binding protein

1

8

High-throughput

0.445

High

1101138

STF1
Steroidogenic factor 1

1

13

Small-scale

0.445

High

1209354

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

6

High-throughput

0.445

High

1219484

RNLS
Renalase

1

1

Small-scale

0.445

High

1295687

SULF2
Extracellular sulfatase Sulf-2

1

3

High-throughput

0.445

High

1295689

RYBP
RING1 and YY1-binding protein

1

4

High-throughput

0.445

High

1295702

S39AD
Zinc transporter ZIP13

1

2

High-throughput

0.445

High

1295730

AGO2
Protein argonaute-2

1

2

High-throughput

0.445

High

1295737

S4A4
Electrogenic sodium bicarbonate cotransporter 1

1

1

High-throughput

0.445

High

106221

APRIO
Alternative prion protein

1

7

High-throughput

0.437

High

914208

EFNA3
Ephrin-A3

1

2

High-throughput

0.437

High

1295686

CUL9
Cullin-9

1

4

Small-scale

0.437

High

1295690

ARL10
ADP-ribosylation factor-like protein 10

1

5

High-throughput

0.437

High

1295692

CEP76
Centrosomal protein of 76 kDa

1

1

High-throughput

0.437

High

1295697

ZUP1
Zinc finger-containing ubiquitin peptidase 1

1

5

Small-scale

0.437

High

1295700

RNF31
E3 ubiquitin-protein ligase RNF31

1

17

High-throughput

0.437

High

1295704

DIRA2
GTP-binding protein Di-Ras2

1

2

Small-scale

0.437

High

1295736

PPME1
Protein phosphatase methylesterase 1

1

1

Small-scale

0.437

High

1077

SIM26
Small integral membrane protein 26

1

1

High-throughput

0.407

High

653425

HEMH
Ferrochelatase, mitochondrial

1

1

High-throughput

0.407

High

725791

RIR2
Ribonucleoside-diphosphate reductase subunit M2

1

0

High-throughput

0.279

Low

1295703

COQ2
4-hydroxybenzoate polyprenyltransferase, mitochondrial

1

0

High-throughput

0.279

Low

1126117

GRM2
Metabotropic glutamate receptor 2

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025