HitPredict

Interactor 1: TCAM1 (Q8IUC6)
TIR domain-containing adapter molecule 1 (TICAM-1) (Proline-rich, vinculin and TIR domain-containing protein B) (Putative NF-kappa-B-activating protein 502H) (Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta) (MyD88-3) (TIR domain-containing adapter protein inducing IFN-beta)
Gene: TICAM1

Interactor 2: TRAF6 (Q9Y4K3)
TNF receptor-associated factor 6 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF6) (Interleukin-1 signal transducer) (RING finger protein 85) (RING-type E3 ubiquitin transferase TRAF6)
Gene: TRAF6

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.95 0.60 0.756

The method score is based on:

Property Details
Experiments 20047764, 14530355, 24812060, 25736436, 14982987, 15474016, 19795416, 14739303, 16281057
Identification Methods affinity chromatography technology, pull down, two hybrid, anti tag coimmunoprecipitation
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005829 - cytosol
GO:0010008 - endosome membrane
GO:0031398 - positive regulation of protein ubiquitination
GO:0031663 - lipopolysaccharide-mediated signaling pathway
GO:0032481 - positive regulation of type I interferon production
and 7 others

more...
Homologous interactions 11

Homologous interactions

Color coding for hit scores

1 712
Hs

1 522
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Last updated: 15 Jul 2024