Protein: SH3R3
E3 ubiquitin-protein ligase SH3RF3 (EC 2.3.2.27) (Plenty of SH3s 2) (SH3 domain-containing RING finger protein 3) (SH3 multiple domains protein 4)

Gene: SH3R3, SH3RF3
Organism: Homo sapiens
Interactions: 56
UniProt ID: Q8TEJ3

Gene Ontology (top 5):
GO:0008270 - zinc ion binding
GO:0016567 - protein ubiquitination
GO:0032436 - positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0046330 - positive regulation of JNK cascade
GO:0051865 - protein autoubiquitination

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

242385

PRKN
E3 ubiquitin-protein ligase parkin

1

13

High-throughput

0.618

High

508326

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

14

Small-scale

0.618

High

1309228

KSR1
Kinase suppressor of Ras 1

1

20

High-throughput

0.618

High

1352644

JIP1
C-Jun-amino-terminal kinase-interacting protein 1

1

17

Small-scale

0.618

High

730084

1433B
14-3-3 protein beta/alpha

3

20

High-throughput

0.604

High

966660

1433G
14-3-3 protein gamma

3

20

High-throughput

0.604

High

1113807

CUL3
Cullin-3

2

8

High-throughput

0.584

High

269586

SRGP2
SLIT-ROBO Rho GTPase-activating protein 2

1

20

High-throughput

0.553

High

1103716

JIP2
C-Jun-amino-terminal kinase-interacting protein 2

1

20

Small-scale

0.553

High

1216076

SPD2A
SH3 and PX domain-containing protein 2A

1

19

High-throughput

0.553

High

1293239

RGPS2
Ras-specific guanine nucleotide-releasing factor RalGPS2

1

20

High-throughput

0.553

High

1352629

MAGI1
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

1

20

High-throughput

0.553

High

1352630

TESK2
Dual specificity testis-specific protein kinase 2

1

7

High-throughput

0.553

High

1352633

RTKN
Rhotekin

1

3

High-throughput

0.553

High

1352635

TANC2
Protein TANC2

1

10

High-throughput

0.553

High

988550

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

Small-scale

0.538

High

211581

SIAH2
E3 ubiquitin-protein ligase SIAH2

1

12

Small-scale

0.536

High

1097217

PAK2
Serine/threonine-protein kinase PAK 2

1

20

Small-scale

0.528

High

1105816

ADA15
Disintegrin and metalloproteinase domain-containing protein 15

1

20

Small-scale

0.512

High

971817

1433E
14-3-3 protein epsilon

1

13

High-throughput

0.489

High

1049598

1433F
14-3-3 protein eta

1

20

High-throughput

0.489

High

162017

MP2K7
Dual specificity mitogen-activated protein kinase kinase 7

1

12

Small-scale

0.479

High

853832

MK09
Mitogen-activated protein kinase 9

1

8

Small-scale

0.479

High

941028

HDAC4
Histone deacetylase 4

1

14

High-throughput

0.479

High

955404

CDC42
Cell division control protein 42 homolog

1

20

Small-scale

0.479

High

1338294

FBX22
F-box only protein 22

1

2

High-throughput

0.479

High

1352641

ZBT21
Zinc finger and BTB domain-containing protein 21

1

3

High-throughput

0.479

High

1352643

JIP3
C-Jun-amino-terminal kinase-interacting protein 3

1

20

Small-scale

0.479

High

573594

ENPL
Endoplasmin

1

6

High-throughput

0.470

High

1352634

B2L13
Bcl-2-like protein 13

1

1

Small-scale

0.439

High

176854

DCLK1
Serine/threonine-protein kinase DCLK1

1

7

High-throughput

0.437

High

208708

SI1L1
Signal-induced proliferation-associated 1-like protein 1

1

4

High-throughput

0.437

High

245254

MAST3
Microtubule-associated serine/threonine-protein kinase 3

1

13

High-throughput

0.437

High

252125

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

1

High-throughput

0.437

High

281381

GGYF1
GRB10-interacting GYF protein 1

1

10

High-throughput

0.437

High

637933

NF1
Neurofibromin

1

13

High-throughput

0.437

High

719356

MPIP3
M-phase inducer phosphatase 3

1

2

High-throughput

0.437

High

853716

MK08
Mitogen-activated protein kinase 8

1

8

Small-scale

0.437

High

853897

MP2K4
Dual specificity mitogen-activated protein kinase kinase 4

1

20

Small-scale

0.437

High

1090162

PTN13
Tyrosine-protein phosphatase non-receptor type 13

1

20

High-throughput

0.437

High

1219604

DEN4C
DENN domain-containing protein 4C

1

9

High-throughput

0.437

High

1251390

GGYF2
GRB10-interacting GYF protein 2

1

20

High-throughput

0.437

High

1340981

THOC2
THO complex subunit 2

1

13

High-throughput

0.437

High

1352595

DEN1A
DENN domain-containing protein 1A

1

12

High-throughput

0.437

High

1352631

SIN1
Target of rapamycin complex 2 subunit MAPKAP1

1

1

High-throughput

0.437

High

1352632

LPIN3
Phosphatidate phosphatase LPIN3

1

2

High-throughput

0.437

High

1352636

KI13B
Kinesin-like protein KIF13B

1

20

High-throughput

0.437

High

1352637

INP5E
Phosphatidylinositol polyphosphate 5-phosphatase type IV

1

20

High-throughput

0.437

High

1352638

LRFN1
Leucine-rich repeat and fibronectin type III domain-containing protein 1

1

2

High-throughput

0.437

High

1352639

CING
Cingulin

1

10

High-throughput

0.437

High

1352640

LIMA1
LIM domain and actin-binding protein 1

1

20

High-throughput

0.437

High

1352642

PPM1H
Protein phosphatase 1H

1

5

High-throughput

0.437

High

1352645

CBY1
Protein chibby homolog 1

1

1

High-throughput

0.437

High

1352646

KCTD3
BTB/POZ domain-containing protein KCTD3

1

16

High-throughput

0.437

High

1199618

KLH22
Kelch-like protein 22

1

8

High-throughput

0.407

High

1258517

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

5

High-throughput

0.407

High


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Last updated: 11Aug2025