HitPredict

Interactor 1: M4K3 (Q8IVH8)
Mitogen-activated protein kinase kinase kinase kinase 3 (EC 2.7.11.1) (Germinal center kinase-related protein kinase) (GLK) (MAPK/ERK kinase kinase kinase 3) (MEK kinase kinase 3) (MEKKK 3)
Gene: MAP4K3

Interactor 2: STRN4 (Q9NRL3)
Striatin-4 (Zinedin)
Gene: STRN4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	32640226
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 894 Hs			1 753
+	Hs
		1018195 M4K2_HUMAN (5-894): 0: 833: 51.01		STRN4_HUMAN (1-753): 0: 566: 100.00
+	Hs
		1272899 M4K1_HUMAN (6-893): 0: 782: 39.19		STRN4_HUMAN (1-753): 0: 566: 100.00
+	Hs
		1272883 M4K1_HUMAN (6-893): 0: 782: 39.19		FBXW7_HUMAN (467-752): 2.04e-62: 224: 15.03
+	Hs
		1038927 KCC2B_HUMAN (14-543): 1.02e-128: 404: 19.07		STRN4_HUMAN (1-753): 0: 566: 100.00
+	Hs
		1023123 STK4_HUMAN (10-288): 2.22e-119: 373: 46.43		STRN4_HUMAN (1-753): 0: 566: 100.00
+	Hs
		1022815 KCC2B_HUMAN (14-543): 1.02e-128: 404: 19.07		STRN3_HUMAN (22-753): 8.07e-152: 463: 48.27
+	Rn
		936839 AKT3_RAT (1-344): 2.3e-132: 406: 22.82		STRN_RAT (36-753): 6.92e-148: 453: 48.17
+	Hs
		215228 KCC2B_HUMAN (14-543): 1.02e-128: 404: 19.07		STRN_HUMAN (36-753): 8.04e-148: 452: 47.92
+	Hs
		1022811 STK4_HUMAN (10-288): 2.22e-119: 373: 46.43		STRN3_HUMAN (22-753): 8.07e-152: 463: 48.27
+	Hs
		1022814 STK3_HUMAN (10-288): 2.29e-117: 368: 45.36		STRN3_HUMAN (22-753): 8.07e-152: 463: 48.27
+	Hs
		215222 STK4_HUMAN (10-288): 2.22e-119: 373: 46.43		STRN_HUMAN (36-753): 8.04e-148: 452: 47.92
+	Hs
		215226 STK3_HUMAN (10-288): 2.29e-117: 368: 45.36		STRN_HUMAN (36-753): 8.04e-148: 452: 47.92
+	Dm
		87984 Q9VEN3_DROME (11-368): 3.58e-117: 372: 37.40		D3DML3_DROME (56-753): 3.12e-127: 398: 44.01
+	Hs
		681967 AKT1_HUMAN (6-341): 6.7e-134: 410: 23.70		FBXW7_HUMAN (467-752): 2.04e-62: 224: 15.03
+	Hs
		1038897 KCC2B_HUMAN (14-543): 1.02e-128: 404: 19.07		WDR5B_HUMAN (274-618): 2.43e-63: 216: 14.37
+	Hs
		1027412 STK3_HUMAN (10-288): 2.29e-117: 368: 45.36		FBXW7_HUMAN (467-752): 2.04e-62: 224: 15.03
+	Dm
		1213409 AKT1_DROME (9-346): 6.87e-130: 405: 24.28		NLE_DROME (289-465): 4.97e-27: 117: 14.84
+	Hs
		863606 AKT3_HUMAN (1-344): 1.23e-133: 410: 23.10		COPA_HUMAN (362-744): 2.95e-14: 79.1: 15.49
+	Dm
		1213428 AKT1_DROME (9-346): 6.87e-130: 405: 24.28		Q9W0B8_DROME (362-522): 5.17e-13: 74.8: 18.97
+	Hs
		863416 STK4_HUMAN (10-288): 2.22e-119: 373: 46.43		COPA_HUMAN (362-744): 2.95e-14: 79.1: 15.49