Protein: DTX1
E3 ubiquitin-protein ligase DTX1 (EC 2.3.2.27) (Protein deltex-1) (Deltex1) (hDTX1) (RING-type E3 ubiquitin transferase DTX1)

Gene: DTX1
Organism: Homo sapiens
Interactions: 32
UniProt ID: Q86Y01

Gene Ontology (top 5):
GO:0003713 - transcription coactivator activity
GO:0005112 - Notch binding
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1294442

DTX1
E3 ubiquitin-protein ligase DTX1

3

6

Small-scale

0.840

High

857493

NOTC1
Neurogenic locus notch homolog protein 1

3

7

Small-scale

0.646

High

982233

UB2D2
Ubiquitin-conjugating enzyme E2 D2

2

20

Small-scale

0.619

High

1294443

DTX3L
E3 ubiquitin-protein ligase DTX3L

1

7

Small-scale

0.618

High

1294447

DTX4
E3 ubiquitin-protein ligase DTX4

1

6

Small-scale

0.618

High

1294444

ITCH
E3 ubiquitin-protein ligase Itchy homolog

2

1

Small-scale

0.611

High

531102

KAP0
cAMP-dependent protein kinase type I-alpha regulatory subunit

2

1

High-throughput

0.606

High

1067484

EP300
Histone acetyltransferase p300

1

2

Small-scale

0.552

High

144183

UBE2C
Ubiquitin-conjugating enzyme E2 C

1

20

High-throughput

0.541

High

906697

UB2D1
Ubiquitin-conjugating enzyme E2 D1

1

20

High-throughput

0.541

High

909342

UB2E1
Ubiquitin-conjugating enzyme E2 E1

1

20

High-throughput

0.541

High

957126

UB2D3
Ubiquitin-conjugating enzyme E2 D3

1

20

High-throughput

0.541

High

957781

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

20

High-throughput

0.541

High

1100874

G3BP1
Ras GTPase-activating protein-binding protein 1

1

2

High-throughput

0.541

High

1294448

UB2D4
Ubiquitin-conjugating enzyme E2 D4

1

20

High-throughput

0.541

High

1098807

M3K1
Mitogen-activated protein kinase kinase kinase 1

1

0

Small-scale

0.537

High

167520

TX1B3
Tax1-binding protein 3

1

2

Small-scale

0.527

High

1218727

UBE2U
Ubiquitin-conjugating enzyme E2 U

1

20

High-throughput

0.494

High

987748

GRB2
Growth factor receptor-bound protein 2

1

9

Small-scale

0.481

High

67135

UBP27
Ubiquitin carboxyl-terminal hydrolase 27

1

2

Small-scale

0.479

High

131465

EIF3F
Eukaryotic translation initiation factor 3 subunit F

1

1

Small-scale

0.479

High

159733

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

1

High-throughput

0.479

High

508234

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

1

Small-scale

0.479

High

538431

EGR2
E3 SUMO-protein ligase EGR2

1

2

Small-scale

0.479

High

855671

CRK
Adapter molecule crk

1

4

High-throughput

0.479

High

882525

ARRB1
Beta-arrestin-1

1

2

Small-scale

0.479

High

1294445

RPR1A
Regulation of nuclear pre-mRNA domain-containing protein 1A

1

3

Small-scale

0.479

High

193027

CFLAR
CASP8 and FADD-like apoptosis regulator

1

0

Small-scale

0.458

High

1030798

DEF5
Defensin alpha 5

1

0

High-throughput

0.282

High

1147630

TOM20
Mitochondrial import receptor subunit TOM20 homolog

1

0

Small-scale

0.249

Low

1294446

T126A
Transmembrane protein 126A

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025