Protein: RPR1A
Regulation of nuclear pre-mRNA domain-containing protein 1A (Cyclin-dependent kinase inhibitor 2B-related protein) (p15INK4B-related protein)

Gene: RPR1A, RPRD1A
Organism: Homo sapiens
Interactions: 154
UniProt ID: Q96P16

Gene Ontology (top 5):
GO:0000993 - RNA polymerase II complex binding
GO:0001111 - RNA polymerase II promoter clearance
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0031124 - mRNA 3'-end processing

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1399361

RPR1B
Regulation of nuclear pre-mRNA domain-containing protein 1B

9

13

Small-scale

0.975

High

667415

RPB1
DNA-directed RNA polymerase II subunit RPB1

2

15

Small-scale

0.811

High

1399343

RPR1A
Regulation of nuclear pre-mRNA domain-containing protein 1A

1

12

Small-scale

0.716

High

976135

RPB7
DNA-directed RNA polymerase II subunit RPB7

4

7

High-throughput

0.699

High

1217605

RPRD2
Regulation of nuclear pre-mRNA domain-containing protein 2

1

14

High-throughput

0.691

High

192846

RPB4
DNA-directed RNA polymerase II subunit RPB4

3

5

High-throughput

0.675

High

912219

RPB11
DNA-directed RNA polymerase II subunit RPB11-a

3

3

High-throughput

0.662

High

246875

KDM1A
Lysine-specific histone demethylase 1A

4

0

High-throughput

0.661

High

1313035

RPAP2
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

2

3

Small-scale

0.649

High

681903

RBTN2
Rhombotin-2

2

3

High-throughput

0.628

High

723057

RPB2
DNA-directed RNA polymerase II subunit RPB2

2

13

High-throughput

0.628

High

923525

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

2

4

High-throughput

0.628

High

983690

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

2

3

High-throughput

0.628

High

1358182

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

2

1

High-throughput

0.628

High

326366

SCAF4
SR-related and CTD-associated factor 4

1

2

High-throughput

0.618

High

1232007

GL1AD
DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5

4

3

High-throughput

0.617

High

506023

GRL1A
DNA-directed RNA polymerase II subunit GRINL1A

3

3

High-throughput

0.611

High

959035

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

2

3

High-throughput

0.611

High

1399357

GPN1
GPN-loop GTPase 1

2

6

High-throughput

0.611

High

140410

SDCB1
Syntenin-1

2

2

High-throughput

0.606

High

783741

ZNF76
Zinc finger protein 76

2

1

High-throughput

0.606

High

1290550

ZN410
Zinc finger protein 410

2

2

High-throughput

0.606

High

1399373

NXF1
Nuclear RNA export factor 1

2

1

High-throughput

0.606

High

1316966

FAM9B
Protein FAM9B

2

1

High-throughput

0.601

High

1399368

ASB6
Ankyrin repeat and SOCS box protein 6

2

2

High-throughput

0.574

High

138752

IMA4
Importin subunit alpha-4

1

2

High-throughput

0.573

High

177401

ARHGB
Rho guanine nucleotide exchange factor 11

2

2

High-throughput

0.571

High

1399375

GPN3
GPN-loop GTPase 3

2

6

High-throughput

0.558

High

1165305

LONF1
LON peptidase N-terminal domain and RING finger protein 1

2

5

High-throughput

0.553

High

1399345

RIOK2
Serine/threonine-protein kinase RIO2

1

1

High-throughput

0.541

High

74574

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

1

High-throughput

0.536

High

158490

RFXK
DNA-binding protein RFXANK

1

1

High-throughput

0.536

High

316310

RECQ5
ATP-dependent DNA helicase Q5

1

8

High-throughput

0.536

High

445242

S10A6
Protein S100-A6

1

4

High-throughput

0.536

High

621720

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

11

High-throughput

0.536

High

621939

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

1

4

High-throughput

0.536

High

787775

RPB9
DNA-directed RNA polymerase II subunit RPB9

1

8

High-throughput

0.536

High

912107

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

1

4

High-throughput

0.536

High

1036677

APBA1
Amyloid-beta A4 precursor protein-binding family A member 1

1

2

High-throughput

0.536

High

1065371

SSRP1
FACT complex subunit SSRP1

1

7

High-throughput

0.536

High

1100969

G3BP1
Ras GTPase-activating protein-binding protein 1

1

4

High-throughput

0.536

High

1270325

SPT6H
Transcription elongation factor SPT6

1

4

High-throughput

0.536

High

1334793

SERB1
SERPINE1 mRNA-binding protein 1

1

1

High-throughput

0.536

High

1395754

UBP47
Ubiquitin carboxyl-terminal hydrolase 47

1

1

High-throughput

0.536

High

1399352

SFR19
Splicing factor, arginine/serine-rich 19

1

8

High-throughput

0.536

High

1399362

ANLN
Anillin

1

1

High-throughput

0.536

High

1399363

CENPM
Centromere protein M

1

1

High-throughput

0.536

High

1399381

KDM2A
Lysine-specific demethylase 2A

1

1

High-throughput

0.536

High

990620

1433Z
14-3-3 protein zeta/delta

1

0

High-throughput

0.518

High

415130

MT1F
Metallothionein-1F

1

0

High-throughput

0.513

High

708999

T2EB
Transcription initiation factor IIE subunit beta

1

0

High-throughput

0.513

High

1144131

TEBP
Prostaglandin E synthase 3

1

0

High-throughput

0.513

High

1226000

ICE2
Little elongation complex subunit 2

1

0

High-throughput

0.513

High

1369048

GGH
Gamma-glutamyl hydrolase

1

0

High-throughput

0.513

High

1383815

EFMT3
EEF1A lysine methyltransferase 3

1

0

High-throughput

0.513

High

1399348

PITH1
PITH domain-containing protein 1

1

0

High-throughput

0.513

High

294884

BCAR3
Breast cancer anti-estrogen resistance protein 3

1

3

High-throughput

0.494

High

387876

FIBB
Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain]

1

1

High-throughput

0.489

High

1012241

RT11
Small ribosomal subunit protein uS11m

1

1

High-throughput

0.489

High

1382370

SPSB4
SPRY domain-containing SOCS box protein 4

1

5

High-throughput

0.489

High

128467

PSMD9
26S proteasome non-ATPase regulatory subunit 9

1

1

High-throughput

0.479

High

132760

BMAL1
Basic helix-loop-helix ARNT-like protein 1

1

2

High-throughput

0.479

High

165075

RPC1
DNA-directed RNA polymerase III subunit RPC1

1

15

High-throughput

0.479

High

180364

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

11

High-throughput

0.479

High

191057

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

3

High-throughput

0.479

High

192955

CLOCK
Circadian locomoter output cycles protein kaput

1

2

High-throughput

0.479

High

262559

MCE1
mRNA-capping enzyme

1

3

High-throughput

0.479

High

287467

RPC9
DNA-directed RNA polymerase III subunit RPC9

1

2

High-throughput

0.479

High

315901

RECQ4
ATP-dependent DNA helicase Q4

1

8

High-throughput

0.479

High

316428

RMP
Unconventional prefoldin RPB5 interactor 1

1

2

High-throughput

0.479

High

340023

RPA1
DNA-directed RNA polymerase I subunit RPA1

1

15

High-throughput

0.479

High

372882

MYC
Myc proto-oncogene protein

1

6

High-throughput

0.479

High

406525

MYCN
N-myc proto-oncogene protein

1

6

High-throughput

0.479

High

414435

P53
Cellular tumor antigen p53

1

1

High-throughput

0.479

High

430250

JUN
Transcription factor Jun

1

4

High-throughput

0.479

High

430636

RPC4
DNA-directed RNA polymerase III subunit RPC4

1

2

High-throughput

0.479

High

623492

RO52
E3 ubiquitin-protein ligase TRIM21

1

1

Small-scale

0.479

High

731545

STIP1
Stress-induced-phosphoprotein 1

1

3

High-throughput

0.479

High

799406

BRCA1
Breast cancer type 1 susceptibility protein

1

5

High-throughput

0.479

High

959637

MAX
Protein max

1

6

High-throughput

0.479

High

1033161

EWS
RNA-binding protein EWS

1

6

High-throughput

0.479

High

1033752

PO5F1
POU domain, class 5, transcription factor 1

1

2

High-throughput

0.479

High

1107115

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

High-throughput

0.479

High

1108384

MED21
Mediator of RNA polymerase II transcription subunit 21

1

2

High-throughput

0.479

High

1122431

GIT2
ARF GTPase-activating protein GIT2

1

2

High-throughput

0.479

High

1294445

DTX1
E3 ubiquitin-protein ligase DTX1

1

3

Small-scale

0.479

High

1329817

SIR6
NAD-dependent protein deacylase sirtuin-6

1

3

High-throughput

0.479

High

1350703

CCHCR
Coiled-coil alpha-helical rod protein 1

1

1

High-throughput

0.479

High

1384413

PF21A
PHD finger protein 21A

1

2

High-throughput

0.479

High

1399344

MED10
Mediator of RNA polymerase II transcription subunit 10

1

3

High-throughput

0.479

High

1399349

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

2

High-throughput

0.479

High

1399353

RPA2
DNA-directed RNA polymerase I subunit RPA2

1

13

High-throughput

0.479

High

1399359

HM20A
High mobility group protein 20A

1

7

High-throughput

0.479

High

1399360

MED4
Mediator of RNA polymerase II transcription subunit 4

1

2

High-throughput

0.479

High

1399365

RPC5
DNA-directed RNA polymerase III subunit RPC5

1

2

High-throughput

0.479

High

1399366

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

13

High-throughput

0.479

High

1399367

PIHD1
PIH1 domain-containing protein 1

1

2

High-throughput

0.479

High

1399369

WWOX
WW domain-containing oxidoreductase

1

4

High-throughput

0.479

High

1399370

RPA12
DNA-directed RNA polymerase I subunit RPA12

1

8

High-throughput

0.479

High

1399372

UXT
Protein UXT

1

2

High-throughput

0.479

High

1399374

PFD2
Prefoldin subunit 2

1

2

High-throughput

0.479

High

1399376

XPO7
Exportin-7

1

5

High-throughput

0.479

High

1399379

RCOR1
REST corepressor 1

1

1

High-throughput

0.479

High

1399383

RPC10
DNA-directed RNA polymerase III subunit RPC10

1

8

High-throughput

0.479

High

1399384

RPC8
DNA-directed RNA polymerase III subunit RPC8

1

7

High-throughput

0.479

High

217182

MS18B
Protein Mis18-beta

1

0

High-throughput

0.458

High

340389

YETS4
YEATS domain-containing protein 4

1

0

High-throughput

0.458

High

363730

EGFR
Epidermal growth factor receptor

1

0

High-throughput

0.458

High

390142

ALBU
Albumin

1

0

Small-scale

0.458

High

503650

TFPT
TCF3 fusion partner

1

0

High-throughput

0.458

High

1196302

GRAP1
GRIP1-associated protein 1

1

0

High-throughput

0.458

High

1239918

CAVN1
Caveolae-associated protein 1

1

0

High-throughput

0.458

High

1243040

PKN3
Serine/threonine-protein kinase N3

1

0

High-throughput

0.458

High

1389065

THA11
THAP domain-containing protein 11

1

0

High-throughput

0.458

High

1399346

NUF2
Kinetochore protein Nuf2

1

0

High-throughput

0.458

High

1399354

LN28A
Protein lin-28 homolog A

1

3

High-throughput

0.445

High

1399380

CHIP
E3 ubiquitin-protein ligase CHIP

1

2

High-throughput

0.445

High

1255123

TRI67
Tripartite motif-containing protein 67

1

7

High-throughput

0.437

High

1328550

NGEF
Ephexin-1

1

2

High-throughput

0.437

High

1348300

GOGA5
Golgin subfamily A member 5

1

1

High-throughput

0.437

High

1360802

ASB11
Ankyrin repeat and SOCS box protein 11

1

1

High-throughput

0.437

High

1398603

DAA10
Dynein axonemal assembly factor 10

1

2

High-throughput

0.437

High

1399350

PKHA4
Pleckstrin homology domain-containing family A member 4

1

4

High-throughput

0.437

High

1399351

RPAP3
RNA polymerase II-associated protein 3

1

3

High-throughput

0.437

High

1399355

ARGAL
Rho guanine nucleotide exchange factor 10-like protein

1

1

High-throughput

0.437

High

1399358

TUFT1
Tuftelin

1

2

High-throughput

0.437

High

1399364

PDRG1
p53 and DNA damage-regulated protein 1

1

2

High-throughput

0.437

High

1399371

PHRF1
PHD and RING finger domain-containing protein 1

1

9

High-throughput

0.437

High

344290

PTBP3
Polypyrimidine tract-binding protein 3

1

0

High-throughput

0.426

High

505970

MYZAP
Myocardial zonula adherens protein

1

3

High-throughput

0.407

High

1227289

A16L1
Autophagy-related protein 16-1

1

3

High-throughput

0.407

High

416037

CP1A1
Cytochrome P450 1A1

2

0

High-throughput

0.318

High

169718

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

2

0

High-throughput

0.316

High

1295090

F90A1
Protein FAM90A1

2

0

High-throughput

0.316

High

340214

PCNT
Pericentrin

1

0

High-throughput

0.282

High

652391

TGM1
Protein-glutamine gamma-glutamyltransferase K

1

0

High-throughput

0.279

Low

85302

RBG10
Rab GTPase-activating protein 1-like, isoform 10

1

0

High-throughput

0.249

Low

1124889

FLOT2
Flotillin-2

1

0

High-throughput

0.249

Low

1153705

CH3L2
Chitinase-3-like protein 2

1

0

High-throughput

0.249

Low

1201151

CCD93
Coiled-coil domain-containing protein 93

1

0

High-throughput

0.249

Low

1217277

VPS53
Vacuolar protein sorting-associated protein 53 homolog

1

0

High-throughput

0.249

Low

1237917

PHLB3
Pleckstrin homology-like domain family B member 3

1

0

High-throughput

0.249

Low

1249130

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

1278432

HAUS6
HAUS augmin-like complex subunit 6

1

0

High-throughput

0.249

Low

1294554

DZIP3
E3 ubiquitin-protein ligase DZIP3

1

0

High-throughput

0.249

Low

1357407

DEP1B
DEP domain-containing protein 1B

1

0

High-throughput

0.249

Low

1394921

VPS50
Syndetin

1

0

High-throughput

0.249

Low

1399347

B2L14
Apoptosis facilitator Bcl-2-like protein 14

1

0

Small-scale

0.249

Low

1399356

NCK5L
Nck-associated protein 5-like

1

0

High-throughput

0.249

Low

1399377

VPS51
Vacuolar protein sorting-associated protein 51 homolog

1

0

High-throughput

0.249

Low

1399378

RABX5
Rab5 GDP/GTP exchange factor

1

0

High-throughput

0.249

Low

1399382

GSTK1
Glutathione S-transferase kappa 1

1

0

High-throughput

0.249

Low

231618

PRKY
Putative serine/threonine-protein kinase PRKY

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025