HitPredict

Interactor 1: PHC2 (Q8IXK0)
Polyhomeotic-like protein 2 (hPH2) (Early development regulatory protein 2)
Gene: PHC2

Interactor 2: RING2 (Q99496)
E3 ubiquitin-protein ligase RING2 (EC 2.3.2.27) (Huntingtin-interacting protein 2-interacting protein 3) (HIP2-interacting protein 3) (Protein DinG) (RING finger protein 1B) (RING1b) (RING finger protein 2) (RING finger protein BAP-1) (RING-type E3 ubiquitin transferase RING2)
Gene: RNF2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.93	0.60	0.750

Property	Details
Experiments	27705803, 24981860, 37014752, 22325352, 24457600, 26496610, 31093962, 15563468
Identification Methods	affinity chromatography technology, pull down, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0008270 - zinc ion binding GO:0031519 - PcG protein complex and 1 others more... GO:0035102 - PRC1 complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 858 Hs			1 336
+	Mm
		1321743 PHC2_MOUSE (1-858): 2.51e-83: 287: 85.40		RING2_MOUSE (1-336): 4.78e-112: 330: 99.70
+	Hs
		987988 PHC2_HUMAN (1-858): 9.36e-98: 326: 100.00		RING1_HUMAN (6-336): 8.6e-69: 222: 51.24
+	Mm
		193416 PHC2_MOUSE (1-858): 2.51e-83: 287: 85.40		RING1_MOUSE (6-336): 1.23e-70: 227: 51.49
+	Hs
		943084 PHC1_HUMAN (44-858): 3.94e-44: 174: 26.40		RING2_HUMAN (1-336): 4.99e-112: 330: 100.00
+	Hs
		1220909 PHC2_HUMAN (1-858): 9.36e-98: 326: 100.00		R4GMX3_HUMAN (33-332): 1.11e-45: 163: 15.46
+	Hs
		1220881 PHC2_HUMAN (1-858): 9.36e-98: 326: 100.00		PCGF1_HUMAN (28-336): 1.84e-47: 162: 16.88
+	Hs
		717999 PHC2_HUMAN (1-858): 9.36e-98: 326: 100.00		BMI1_HUMAN (34-332): 4.13e-45: 158: 15.51
+	Hs
		718408 PHC2_HUMAN (1-858): 9.36e-98: 326: 100.00		PCGF2_HUMAN (34-332): 8.08e-44: 155: 16.89
+	Hs
		1108515 PHC2_HUMAN (1-858): 9.36e-98: 326: 100.00		PCGF3_HUMAN (36-334): 3.56e-44: 153: 18.15
+	Hs
		1220886 PHC2_HUMAN (1-858): 9.36e-98: 326: 100.00		PCGF6_HUMAN (29-296): 6.61e-39: 142: 14.76
+	Hs
		1197568 PHC2_HUMAN (1-858): 9.36e-98: 326: 100.00		PCGF5_HUMAN (34-334): 1.89e-39: 141: 15.24
+	Mm
		639480 PHC2_MOUSE (1-858): 2.51e-83: 287: 85.40		BMI1_MOUSE (34-332): 1.69e-44: 156: 15.23
+	Mm
		620794 PHC2_MOUSE (1-858): 2.51e-83: 287: 85.40		PCGF2_MOUSE (34-332): 2.29e-41: 149: 15.56
+	Hs
		943060 PHC1_HUMAN (44-858): 3.94e-44: 174: 26.40		RING1_HUMAN (6-336): 8.6e-69: 222: 51.24
+	Hs
		943087 PHC1_HUMAN (44-858): 3.94e-44: 174: 26.40		PCGF1_HUMAN (28-336): 1.84e-47: 162: 16.88
+	Hs
		717684 PHC1_HUMAN (44-858): 3.94e-44: 174: 26.40		BMI1_HUMAN (34-332): 4.13e-45: 158: 15.51
+	Hs
		718390 PHC1_HUMAN (44-858): 3.94e-44: 174: 26.40		PCGF2_HUMAN (34-332): 8.08e-44: 155: 16.89
+	Hs
		943064 PHC1_HUMAN (44-858): 3.94e-44: 174: 26.40		PCGF3_HUMAN (36-334): 3.56e-44: 153: 18.15
+	Hs
		943070 PHC1_HUMAN (44-858): 3.94e-44: 174: 26.40		PCGF5_HUMAN (34-334): 1.89e-39: 141: 15.24
+	Hs
		943066 PHC1_HUMAN (44-858): 3.94e-44: 174: 26.40		Q5T8Z6_HUMAN (34-146): 4.7e-31: 114: 23.28