HitPredict - High confidence protein-protein interactions

Interactor 1: VDAC1 (Q60932)
Non-selective voltage-gated ion channel VDAC1 (Outer mitochondrial membrane protein porin 1) (Plasmalemmal porin) (Voltage-dependent anion-selective channel protein 1) (VDAC-1) (mVDAC1) (Voltage-dependent anion-selective channel protein 5) (VDAC-5) (mVDAC5)
Gene: VDAC1

Interactor 2: VDAC1 (Q60932)
Non-selective voltage-gated ion channel VDAC1 (Outer mitochondrial membrane protein porin 1) (Plasmalemmal porin) (Voltage-dependent anion-selective channel protein 1) (VDAC-1) (mVDAC1) (Voltage-dependent anion-selective channel protein 5) (VDAC-5) (mVDAC5)
Gene: VDAC1

Species: Mus musculus

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.68	1.00	0.827

Property	Details
Experiments	29199018, 29222160, 28130547
Identification Methods	cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Porin_3~Porin_3
Common GO terms	GO:0001662 - behavioral fear response GO:0005244 - voltage-gated monoatomic ion channel activity GO:0005524 - ATP binding GO:0005739 - mitochondrion GO:0005741 - mitochondrial outer membrane and 30 others more... GO:0005743 - mitochondrial inner membrane GO:0005757 - mitochondrial permeability transition pore complex GO:0005886 - plasma membrane GO:0006086 - pyruvate decarboxylation to acetyl-CoA GO:0006869 - lipid transport GO:0006915 - apoptotic process GO:0007268 - chemical synaptic transmission GO:0007270 - neuron-neuron synaptic transmission GO:0007612 - learning GO:0008142 - oxysterol binding GO:0008308 - voltage-gated monoatomic anion channel activity GO:0015288 - porin activity GO:0015485 - cholesterol binding GO:0016020 - membrane GO:0019901 - protein kinase binding GO:0030855 - epithelial cell differentiation GO:0031210 - phosphatidylcholine binding GO:0036444 - calcium import into the mitochondrion GO:0042645 - mitochondrial nucleoid GO:0043065 - positive regulation of apoptotic process GO:0043066 - negative regulation of apoptotic process GO:0043209 - myelin sheath GO:0044325 - transmembrane transporter binding GO:0045121 - membrane raft GO:0045202 - synapse GO:0097001 - ceramide binding GO:0110099 - negative regulation of calcium import into the mitochondrion GO:1901524 - regulation of mitophagy GO:1905091 - positive regulation of type 2 mitophagy GO:2000378 - negative regulation of reactive oxygen species metabolic process
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1	296
Mm

1	296

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Last updated: 11Aug2025