HitPredict - High confidence protein-protein interactions

Interactor 1: VDAC1 (P21796)
Non-selective voltage-gated ion channel VDAC1 (Outer mitochondrial membrane protein porin 1) (Plasmalemmal porin) (Porin 31HL) (Porin 31HM) (Voltage-dependent anion-selective channel protein 1) (VDAC-1) (hVDAC1)
Gene: VDAC1

Interactor 2: VDAC1 (P21796)
Non-selective voltage-gated ion channel VDAC1 (Outer mitochondrial membrane protein porin 1) (Plasmalemmal porin) (Porin 31HL) (Porin 31HM) (Voltage-dependent anion-selective channel protein 1) (VDAC-1) (hVDAC1)
Gene: VDAC1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	37296105, 18832158
Identification Methods	affinity chromatography technology, nuclear magnetic resonance, x-ray crystallography, cross-linking study, molecular sieving
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	Porin_3~Porin_3
Common GO terms	GO:0001662 - behavioral fear response GO:0005244 - voltage-gated monoatomic ion channel activity GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005739 - mitochondrion and 33 others more... GO:0005741 - mitochondrial outer membrane GO:0005757 - mitochondrial permeability transition pore complex GO:0005886 - plasma membrane GO:0006090 - pyruvate metabolic process GO:0006820 - monoatomic anion transport GO:0006869 - lipid transport GO:0006915 - apoptotic process GO:0007270 - neuron-neuron synaptic transmission GO:0007612 - learning GO:0008142 - oxysterol binding GO:0008308 - voltage-gated monoatomic anion channel activity GO:0015288 - porin activity GO:0015485 - cholesterol binding GO:0016020 - membrane GO:0019901 - protein kinase binding GO:0030855 - epithelial cell differentiation GO:0031210 - phosphatidylcholine binding GO:0031966 - mitochondrial membrane GO:0036444 - calcium import into the mitochondrion GO:0042645 - mitochondrial nucleoid GO:0043065 - positive regulation of apoptotic process GO:0043066 - negative regulation of apoptotic process GO:0044325 - transmembrane transporter binding GO:0045121 - membrane raft GO:0045202 - synapse GO:0046930 - pore complex GO:0070062 - extracellular exosome GO:0097001 - ceramide binding GO:0110099 - negative regulation of calcium import into the mitochondrion GO:1903146 - regulation of autophagy of mitochondrion GO:1905091 - positive regulation of type 2 mitophagy GO:1990542 - mitochondrial transmembrane transport GO:2000378 - negative regulation of reactive oxygen species metabolic process
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1	283
Hs

1	283

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Last updated: 11Aug2025