HitPredict

Interactor 1: SLX4 (Q8IY92)
Structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12)
Gene: SLX4

Interactor 2: PIAS4 (Q8N2W9)
E3 SUMO-protein ligase PIAS4 (EC 2.3.2.27) (PIASy) (Protein inhibitor of activated STAT protein 4) (Protein inhibitor of activated STAT protein gamma) (PIAS-gamma)
Gene: PIAS4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.656

Property	Details
Experiments	33961781, 37071664, 37059091
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0005654 - nucleoplasm
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 1834 Hs			1 510
+	Hs
		1222664 SLX4_HUMAN (1-1834): 0: 1486: 100.00		PIAS3_HUMAN (3-509): 0: 540: 46.59
+	Hs
		278125 SLX4_HUMAN (1-1834): 0: 1486: 100.00		PIAS1_HUMAN (3-508): 2.66e-180: 522: 46.42
+	Hs
		1222475 SLX4_HUMAN (1-1834): 0: 1486: 100.00		ZMIZ2_HUMAN (70-496): 9.21e-74: 252: 22.32
+	Hs
		1056886 MDC1_HUMAN (801-1763): 7.3e-12: 73.2: 9.54		PIAS4_HUMAN (1-510): 0: 670: 100.00
+	Hs
		1270855 CBP_HUMAN (885-1778): 4.86e-09: 64: 9.57		PIAS3_HUMAN (3-509): 0: 540: 46.59
+	Hs
		278083 MDC1_HUMAN (801-1763): 7.3e-12: 73.2: 9.54		PIAS1_HUMAN (3-508): 2.66e-180: 522: 46.42
+	Hs
		278139 CBP_HUMAN (885-1778): 4.86e-09: 64: 9.57		PIAS1_HUMAN (3-508): 2.66e-180: 522: 46.42
+	Hs
		278313 CBP_HUMAN (885-1778): 4.86e-09: 64: 9.57		PIAS2_HUMAN (3-504): 9.32e-180: 520: 44.74