Protein: BRR2
Pre-mRNA-splicing helicase BRR2 (EC 3.6.4.13) (Protein Snu246)

Gene: BRR2
Organism: Saccharomyces cerevisiae S288C
Interactions: 137
UniProt ID: P32639

Gene Ontology (top 5):
GO:0000388 - spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
GO:0000398 - mRNA splicing, via spliceosome
GO:0000974 - Prp19 complex
GO:0003676 - nucleic acid binding
GO:0003724 - RNA helicase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

744096

PRP8
Pre-mRNA-splicing factor 8

21

11

Small-scale

0.991

High

627841

PRP4
U4/U6 small nuclear ribonucleoprotein PRP4

9

19

Small-scale

0.968

High

628197

PRP2
Pre-mRNA-splicing factor ATP-dependent RNA helicase-like protein PRP2

5

17

Small-scale

0.910

High

744115

SNU13
13 kDa ribonucleoprotein-associated protein

4

5

Small-scale

0.875

High

590186

PRP16
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16

3

19

Small-scale

0.872

High

744184

PRP46
Pre-mRNA-splicing factor PRP46

3

20

High-throughput

0.861

High

744094

BRR2
Pre-mRNA-splicing helicase BRR2

3

17

Small-scale

0.847

High

744099

NCBP1
Nuclear cap-binding protein complex subunit 1

3

7

High-throughput

0.847

High

744169

SP382
Pre-mRNA-splicing factor SPP382

3

0

High-throughput

0.816

High

744134

PRP43
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43

2

20

High-throughput

0.811

High

744138

CWC22
Pre-mRNA-splicing factor CWC22

2

3

High-throughput

0.789

High

744101

SN114
Pre-mRNA-splicing factor SNU114

12

13

Small-scale

0.761

High

744185

SNU66
66 kDa U4/U6.U5 small nuclear ribonucleoprotein component

10

3

Small-scale

0.755

High

624991

PRP6
Pre-mRNA-splicing factor 6

9

20

Small-scale

0.751

High

744128

LSM8
LSM2-LSM8 complex subunit LSM8

10

20

Small-scale

0.750

High

744129

PRP31
Pre-mRNA-processing factor 31

8

8

Small-scale

0.746

High

744154

PRP3
U4/U6 small nuclear ribonucleoprotein PRP3

8

3

Small-scale

0.746

High

744116

RSMB
Small nuclear ribonucleoprotein-associated protein B

8

12

Small-scale

0.745

High

744126

SMD3
Small nuclear ribonucleoprotein Sm D3

7

20

Small-scale

0.742

High

744117

LSM4
LSM complex subunit LSM4

7

10

Small-scale

0.741

High

744145

LSM3
LSM complex subunit LSM3

8

20

Small-scale

0.741

High

744150

SMD1
Small nuclear ribonucleoprotein Sm D1

7

5

Small-scale

0.741

High

744172

DIB1
Spliceosomal protein DIB1

7

2

Small-scale

0.741

High

744105

LSM2
LSM complex subunit LSM2

7

20

Small-scale

0.737

High

744143

LSM7
LSM complex subunit LSM7

6

20

Small-scale

0.724

High

744118

LSM5
LSM complex subunit LSM5

6

2

Small-scale

0.722

High

744168

LSM6
LSM complex subunit LSM6

6

8

Small-scale

0.722

High

744167

SMD2
Small nuclear ribonucleoprotein Sm D2

6

7

Small-scale

0.720

High

744179

CWC2
Pre-mRNA-splicing factor CWC2

5

15

Small-scale

0.718

High

744120

RUXG
Small nuclear ribonucleoprotein G

6

19

Small-scale

0.717

High

744144

RUXF
Small nuclear ribonucleoprotein F

6

8

Small-scale

0.717

High

739117

PRP19
Pre-mRNA-processing factor 19

5

20

Small-scale

0.712

High

744183

SNU23
23 kDa U4/U6.U5 small nuclear ribonucleoprotein component

7

0

Small-scale

0.709

High

744178

RU2A
U2 small nuclear ribonucleoprotein A'

5

10

Small-scale

0.709

High

744156

CEF1
Pre-mRNA-splicing factor CEF1

4

15

Small-scale

0.694

High

744147

PRP38
Pre-mRNA-splicing factor 38

6

0

Small-scale

0.691

High

744160

SYF1
Pre-mRNA-splicing factor SYF1

4

20

Small-scale

0.686

High

744180

CLF1
Pre-mRNA-splicing factor CLF1

4

20

Small-scale

0.686

High

744107

SP381
Pre-mRNA-splicing factor SPP381

5

0

Small-scale

0.682

High

744165

SN309
Pre-mRNA-splicing factor SNT309

3

1

High-throughput

0.667

High

744151

CUS1
Cold sensitive U2 snRNA suppressor 1

3

4

High-throughput

0.664

High

744102

NTR2
Pre-mRNA-splicing factor NTR2

4

0

Small-scale

0.661

High

744182

RUXE
Small nuclear ribonucleoprotein E

4

5

Small-scale

0.659

High

625079

PRP9
Pre-mRNA-splicing factor PRP9

3

1

Small-scale

0.656

High

672044

BUD31
Pre-mRNA-splicing factor BUD31

3

5

Small-scale

0.656

High

739233

PRP21
Pre-mRNA-splicing factor PRP21

3

5

Small-scale

0.656

High

744130

SF3B1
U2 snRNP component HSH155

3

12

Small-scale

0.656

High

744164

RSE1
Pre-mRNA-splicing factor RSE1

3

5

Small-scale

0.656

High

744140

CWC24
Pre-mRNA-splicing factor CWC24

3

4

Small-scale

0.653

High

744177

NCBP2
Nuclear cap-binding protein subunit 2

3

14

High-throughput

0.640

High

744148

RU17
U1 small nuclear ribonucleoprotein 70 kDa homolog

2

17

Small-scale

0.640

High

744111

LIN1
Protein LIN1

2

6

Small-scale

0.628

High

744133

SEH1
Nucleoporin SEH1

1

20

High-throughput

0.618

High

594271

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

3

Small-scale

0.618

High

657959

PRP28
Pre-mRNA-splicing ATP-dependent RNA helicase PRP28

1

18

Small-scale

0.618

High

664584

PRP22
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22

1

19

High-throughput

0.618

High

744125

PRP17
Pre-mRNA-processing factor 17

1

20

High-throughput

0.618

High

638053

ISY1
Pre-mRNA-splicing factor ISY1

2

5

High-throughput

0.611

High

700080

PRP45
Pre-mRNA-processing protein 45

2

10

High-throughput

0.611

High

744106

SLT11
Pre-mRNA-splicing factor SLT11

2

6

High-throughput

0.611

High

744132

CWC23
Pre-mRNA-splicing factor CWC23

2

10

High-throughput

0.611

High

544235

SSB1
Ribosome-associated molecular chaperone SSB1

2

11

High-throughput

0.601

High

744152

SLU7
Pre-mRNA-splicing factor SLU7

2

4

Small-scale

0.600

High

416875

CDC25
Cell division control protein 25

2

0

Small-scale

0.587

High

744155

CWC21
Pre-mRNA-splicing factor CWC21

2

1

Small-scale

0.584

High

744170

URN1
Pre-mRNA-splicing factor URN1

2

0

High-throughput

0.576

High

702237

YJU2
Splicing factor YJU2

2

2

High-throughput

0.571

High

744123

IST3
U2 snRNP component IST3

2

16

High-throughput

0.571

High

526228

HSP72
Heat shock protein SSA2

2

12

High-throughput

0.552

High

403421

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

12

High-throughput

0.536

High

584354

GCN2
eIF-2-alpha kinase GCN2

1

3

High-throughput

0.536

High

744113

PRP39
Pre-mRNA-processing factor 39

1

20

High-throughput

0.536

High

744122

RFC2
Replication factor C subunit 2

1

4

High-throughput

0.536

High

744175

LUC7
Protein LUC7

1

4

High-throughput

0.536

High

738191

NHP2
H/ACA ribonucleoprotein complex subunit NHP2

1

5

High-throughput

0.514

High

744162

SEC13
Protein transport protein SEC13

1

16

High-throughput

0.514

High

744135

SNU71
U1 small nuclear ribonucleoprotein component SNU71

1

0

High-throughput

0.513

High

744139

NOG2
Nucleolar GTP-binding protein 2

1

9

Small-scale

0.508

High

744186

YD85C
SERF-like protein YDL085C-A

1

0

High-throughput

0.493

High

744100

FAB1
1-phosphatidylinositol 3-phosphate 5-kinase FAB1

1

3

Small-scale

0.481

High

744121

ATAD2
ATPase histone chaperone YTA7

1

4

Small-scale

0.481

High

744149

ACAC
Acetyl-CoA carboxylase

1

1

Small-scale

0.481

High

381028

H2B1
Histone H2B.1

1

7

High-throughput

0.479

High

381458

H2B2
Histone H2B.2

1

7

High-throughput

0.479

High

381973

H4
Histone H4

1

9

High-throughput

0.479

High

706568

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.479

High

734899

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

1

High-throughput

0.479

High

738796

NAB2
Nuclear polyadenylated RNA-binding protein NAB2

1

2

High-throughput

0.479

High

740833

PUB1
Nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1

1

15

High-throughput

0.479

High

743163

PP12
Serine/threonine-protein phosphatase PP1-2

1

4

High-throughput

0.479

High

744095

SMY2
Protein SMY2

1

2

Small-scale

0.479

High

744108

NTC20
Pre-mRNA-splicing factor NTC20

1

1

High-throughput

0.479

High

744127

CWC26
Pre-mRNA-splicing factor CWC26

1

3

High-throughput

0.479

High

744136

PESC
Pescadillo homolog

1

3

High-throughput

0.479

High

744137

SYF2
Pre-mRNA-splicing factor SYF2

1

1

High-throughput

0.479

High

744141

CWC25
Pre-mRNA-splicing factor CWC25

1

3

High-throughput

0.479

High

744146

NAM8
Protein NAM8

1

9

High-throughput

0.479

High

744158

CWC15
Pre-mRNA-splicing factor CWC15

1

1

High-throughput

0.479

High

744159

SCC2
Sister chromatid cohesion protein 2

1

3

High-throughput

0.479

High

744166

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

1

High-throughput

0.479

High

744173

RDS3
Pre-mRNA-splicing factor RDS3

1

1

High-throughput

0.479

High

744174

PRP11
Pre-mRNA-splicing factor PRP11

1

5

High-throughput

0.479

High

744176

PML1
Pre-mRNA leakage protein 1

1

2

High-throughput

0.479

High

744187

HSH49
Protein HSH49

1

12

High-throughput

0.479

High

744153

SYH1
SMY2 homolog 2

1

14

Small-scale

0.464

High

449405

SPT2
Protein SPT2

1

0

Small-scale

0.460

High

602118

SPO12
Sporulation-specific protein 12

1

0

Small-scale

0.460

High

744124

MET28
Transcriptional activator of sulfur metabolism MET28

1

0

Small-scale

0.460

High

744161

SPO20
Sporulation-specific protein 20

1

0

Small-scale

0.460

High

603027

EST1
Telomere elongation protein EST1

1

0

High-throughput

0.458

High

743511

RU1A
U1 small nuclear ribonucleoprotein A

1

0

High-throughput

0.458

High

744103

YK21
Uncharacterized protein YKR041W

1

0

High-throughput

0.458

High

392449

HSP82
ATP-dependent molecular chaperone HSP82

1

9

High-throughput

0.445

High

510322

HSP77
Import motor subunit, mitochondrial

1

7

High-throughput

0.445

High

517958

SSBP1
Single-stranded nucleic acid-binding protein

1

9

High-throughput

0.445

High

523418

HSP71
Heat shock protein SSA1

1

12

High-throughput

0.445

High

646118

NPR1
Nitrogen permease reactivator protein

1

7

High-throughput

0.445

High

675838

MAS5
Mitochondrial protein import protein MAS5

1

8

High-throughput

0.445

High

726870

HS104
Heat shock protein 104

1

3

High-throughput

0.445

High

741229

HSP7F
Heat shock protein homolog SSE1

1

20

High-throughput

0.445

High

744097

PRP18
Pre-mRNA-splicing factor 18

1

1

Small-scale

0.445

High

744098

HSP78
Heat shock protein 78, mitochondrial

1

3

High-throughput

0.445

High

744110

SSZ1
Ribosome-associated complex subunit SSZ1

1

4

High-throughput

0.445

High

744119

SSB2
Ribosome-associated molecular chaperone SSB2

1

11

High-throughput

0.445

High

744131

CTF18
Chromosome transmission fidelity protein 18

1

5

High-throughput

0.445

High

744157

ACL4
Assembly chaperone of RPL4

1

0

High-throughput

0.426

High

744142

PFD4
Prefoldin subunit 4

1

3

High-throughput

0.407

High

744163

PFD5
Prefoldin subunit 5

1

2

High-throughput

0.407

High

744171

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

7

High-throughput

0.407

High

744181

HSP42
Heat shock protein 42

1

1

High-throughput

0.407

High

744104

SEA4
SEH-associated protein 4

1

0

High-throughput

0.279

Low

744109

AIM4
Altered inheritance of mitochondria protein 4

1

0

High-throughput

0.279

Low

549967

KAR1
Cell division control protein KAR1

1

0

Small-scale

0.251

Low

744114

GIP4
GLC7-interacting protein 4

1

0

Small-scale

0.251

Low

744112

TIM17
Mitochondrial import inner membrane translocase subunit TIM17

1

0

Small-scale

0.249

Low

613845

ERD2
ER lumen protein-retaining receptor

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025