Interactor 1: SLX4 (Q8IY92)
Structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12)
Gene: SLX4

Interactor 2: XPF (Q92889)
DNA repair endonuclease XPF (EC 3.1.-.-) (DNA excision repair protein ERCC-4) (DNA repair protein complementing XP-F cells) (Xeroderma pigmentosum group F-complementing protein)
Gene: ERCC4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.97 0.60 0.766

The method score is based on:

Property Details
Experiments 25538220, 26453996, 31495888, 33961781, 19596235, 19595721, 23994477, 24012755, 23033263, 23623386, 32398829, 37071664, 37059091, 22902628, 21240275, 19595722, 19596236, 23093618
Identification Methods two hybrid, affinity chromatography technology, pull down, proximity labelling technology, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0000712 - resolution of meiotic recombination intermediates
GO:0000724 - double-strand break repair via homologous recombination
GO:0000781 - chromosome, telomeric region
GO:0005654 - nucleoplasm
GO:0006281 - DNA repair
and 2 others

more...

Homologous interactions 3

Homologous interactions

Color coding for hit scores

1 1834
Hs

1 916
+ Mm
+ Hs
+ Hs

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Last updated: 15 Jul 2024