HitPredict

Interactor 1: SLX4 (Q8IY92)
Structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12)
Gene: SLX4

Interactor 2: ARIP4 (Q9Y4B4)
Helicase ARIP4 (EC 3.6.4.12) (Androgen receptor-interacting protein 4) (RAD54-like protein 2)
Gene: RAD54L2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	37071664, 19596235
Identification Methods	proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1834 Hs			1 1467
+	Hs
		802458 SLX4_HUMAN (1-1834): 0: 1486: 100.00		ATRX_HUMAN (23-1102): 0: 618: 28.83
+	Hs
		1109050 SLX4_HUMAN (1-1834): 0: 1486: 100.00		CHD9_HUMAN (14-1126): 9.74e-177: 588: 15.90
+	Hs
		1222585 SLX4_HUMAN (1-1834): 0: 1486: 100.00		CHD8_HUMAN (5-1340): 1.18e-174: 581: 15.27
+	Hs
		1059725 SLX4_HUMAN (1-1834): 0: 1486: 100.00		CHD4_HUMAN (68-1302): 2.04e-177: 580: 13.79
+	Hs
		847012 SLX4_HUMAN (1-1834): 0: 1486: 100.00		SMCA4_HUMAN (23-1125): 2.79e-179: 580: 17.04
+	Hs
		1222593 SLX4_HUMAN (1-1834): 0: 1486: 100.00		HELLS_HUMAN (116-938): 3.83e-177: 552: 20.95
+	Hs
		976477 SLX4_HUMAN (1-1834): 0: 1486: 100.00		ERCC6_HUMAN (300-891): 1.09e-50: 199: 28.36
+	Hs
		801437 KI67_HUMAN (889-1833): 3.44e-23: 110: 10.79		CHD7_HUMAN (4-1356): 3.77e-177: 590: 14.82
+	Hs
		801399 KI67_HUMAN (889-1833): 3.44e-23: 110: 10.79		CHD8_HUMAN (5-1340): 1.18e-174: 581: 15.27
+	Hs
		801147 KI67_HUMAN (889-1833): 3.44e-23: 110: 10.79		CHD4_HUMAN (68-1302): 2.04e-177: 580: 13.79
+	Hs
		801108 KI67_HUMAN (889-1833): 3.44e-23: 110: 10.79		CHD3_HUMAN (108-1366): 5.26e-175: 575: 14.30
+	Hs
		802469 CBP_HUMAN (885-1778): 4.86e-09: 64: 9.57		ATRX_HUMAN (23-1102): 0: 618: 28.83
+	Hs
		801032 KI67_HUMAN (889-1833): 3.44e-23: 110: 10.79		SMCA2_HUMAN (23-1109): 4.73e-176: 570: 16.85
+	Dm
		332845 Q9VGW4_DROME (894-1788): 1.73e-11: 72: 10.08		CHDM_DROME (59-1285): 2.99e-179: 587: 15.26
+	Hs
		1056830 MDC1_HUMAN (801-1763): 7.3e-12: 73.2: 9.54		CHD4_HUMAN (68-1302): 2.04e-177: 580: 13.79
+	Hs
		965161 ANK2_HUMAN (1147-1751): 8.46e-11: 69.7: 10.18		CHD8_HUMAN (5-1340): 1.18e-174: 581: 15.27
+	Hs
		847041 CBP_HUMAN (885-1778): 4.86e-09: 64: 9.57		SMCA4_HUMAN (23-1125): 2.79e-179: 580: 17.04
+	Hs
		847124 CABIN_HUMAN (880-1364): 9.59e-09: 63.1: 13.91		SMCA4_HUMAN (23-1125): 2.79e-179: 580: 17.04
+	Hs
		1018618 CBP_HUMAN (885-1778): 4.86e-09: 64: 9.57		CHD3_HUMAN (108-1366): 5.26e-175: 575: 14.30
+	Hs
		846837 CBP_HUMAN (885-1778): 4.86e-09: 64: 9.57		SMCA2_HUMAN (23-1109): 4.73e-176: 570: 16.85