Protein: ACVL1
Activin receptor type-1-like (EC 2.7.11.30) (Activin receptor-like kinase 1) (ALK-1) (Serine/threonine-protein kinase receptor R3) (SKR3) (TGF-B superfamily receptor type I) (TSR-I)

Gene: ACVL1, Acvrl1
Organism: Mus musculus
Interactions: 90
UniProt ID: Q61288

Gene Ontology (top 5):
GO:0001525 - angiogenesis
GO:0001701 - in utero embryonic development
GO:0001937 - negative regulation of endothelial cell proliferation
GO:0001938 - positive regulation of endothelial cell proliferation
GO:0001946 - lymphangiogenesis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1222622

TGFR1
TGF-beta receptor type-1

3

19

Small-scale

0.827

High

50046

MELT
Ventricular zone-expressed PH domain-containing protein 1

1

1

High-throughput

0.618

High

109228

G5E884
non-specific serine/threonine protein kinase

1

5

High-throughput

0.618

High

266585

AURKB
Aurora kinase B

1

3

High-throughput

0.618

High

312151

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

8

High-throughput

0.618

High

777178

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

7

High-throughput

0.618

High

981430

RAB3C
Ras-related protein Rab-3C

1

1

High-throughput

0.618

High

989412

RHES
GTP-binding protein Rhes

1

6

High-throughput

0.618

High

1179279

GSK3A
Glycogen synthase kinase-3 alpha

1

10

High-throughput

0.618

High

1221147

KIF1B
Kinesin-like protein KIF1B

1

1

High-throughput

0.618

High

1222619

TGFR2
TGF-beta receptor type-2

1

19

Small-scale

0.618

High

1222623

OXSR1
Serine/threonine-protein kinase OSR1

1

11

High-throughput

0.618

High

1222625

RASL2
Ras GTPase-activating protein 4

1

3

High-throughput

0.618

High

1222638

RAB38
Ras-related protein Rab-38

1

4

High-throughput

0.618

High

1222643

Q91XL1
Leucine-rich HEV glycoprotein

1

20

Small-scale

0.618

High

1222644

NEK8
Serine/threonine-protein kinase Nek8

1

5

High-throughput

0.618

High

1222655

RHOH
Rho-related GTP-binding protein RhoH

1

20

High-throughput

0.618

High

1222657

REBL1
GTPase RhebL1

1

6

High-throughput

0.618

High

1222661

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.618

High

1222662

RGPS2
Ras-specific guanine nucleotide-releasing factor RalGPS2

1

1

High-throughput

0.618

High

1222666

KC1E
Casein kinase I isoform epsilon

1

4

High-throughput

0.618

High

1222669

E2AK4
eIF-2-alpha kinase GCN2

1

3

High-throughput

0.618

High

1222671

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

10

High-throughput

0.618

High

1222672

STK11
Serine/threonine-protein kinase STK11

1

4

High-throughput

0.618

High

1222676

GSK3B
Glycogen synthase kinase-3 beta

1

9

High-throughput

0.618

High

1222620

EGLN
Endoglin

2

12

Small-scale

0.584

High

960638

RAB6B
Ras-related protein Rab-6B

1

12

High-throughput

0.553

High

1050618

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.553

High

1066074

RASLC
Ras-like protein family member 12

1

6

High-throughput

0.553

High

1222618

RANT
GTP-binding nuclear protein Ran, testis-specific isoform

1

4

High-throughput

0.553

High

1222629

RAP2A
Ras-related protein Rap-2a

1

6

High-throughput

0.553

High

1222635

KBRS1
NF-kappa-B inhibitor-interacting Ras-like protein 1

1

11

High-throughput

0.553

High

1222637

ARHG6
Rho guanine nucleotide exchange factor 6

1

5

High-throughput

0.553

High

1222639

ES8L1
Epidermal growth factor receptor kinase substrate 8-like protein 1

1

10

High-throughput

0.553

High

1222645

RAB30
Ras-related protein Rab-30

1

1

High-throughput

0.553

High

1222647

Q99K94
Signal transducer and activator of transcription

1

3

High-throughput

0.553

High

1222652

GRAP
GRB2-related adapter protein

1

18

High-throughput

0.553

High

1222664

PKHO1
Pleckstrin homology domain-containing family O member 1

1

1

High-throughput

0.553

High

1222668

PKHB1
Pleckstrin homology domain-containing family B member 1

1

1

High-throughput

0.553

High

554295

RAPSN
43 kDa receptor-associated protein of the synapse

1

4

High-throughput

0.479

High

937530

CADH5
Cadherin-5

1

9

Small-scale

0.479

High

968109

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

7

High-throughput

0.479

High

968502

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

7

High-throughput

0.479

High

977634

PP2AB
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

1

6

High-throughput

0.479

High

994006

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

6

High-throughput

0.479

High

1190009

UBE2Z
Ubiquitin-conjugating enzyme E2 Z

1

2

High-throughput

0.479

High

1221598

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

7

High-throughput

0.479

High

1222290

FZD7
Frizzled-7

1

2

High-throughput

0.479

High

1222624

BCR
Breakpoint cluster region protein

1

2

High-throughput

0.479

High

1222630

KTNB1
Katanin p80 WD40 repeat-containing subunit B1

1

2

High-throughput

0.479

High

1222641

WDR13
WD repeat-containing protein 13

1

2

High-throughput

0.479

High

1222642

WWOX
WW domain-containing oxidoreductase

1

2

High-throughput

0.479

High

1222648

UBP16
Ubiquitin carboxyl-terminal hydrolase 16

1

17

High-throughput

0.479

High

1222649

ARL4D
ADP-ribosylation factor-like protein 4D

1

6

High-throughput

0.479

High

1222650

PKP2
Plakophilin-2

1

7

High-throughput

0.479

High

1222651

ARHGP
Rho guanine nucleotide exchange factor 25

1

4

High-throughput

0.479

High

1222654

ELP3
Elongator complex protein 3

1

1

High-throughput

0.479

High

1222658

DCAF6
DDB1- and CUL4-associated factor 6

1

5

High-throughput

0.479

High

1222665

UB2J1
Ubiquitin-conjugating enzyme E2 J1

1

16

High-throughput

0.479

High

1222670

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

10

High-throughput

0.479

High

1222677

PAR6A
Partitioning defective 6 homolog alpha

1

7

High-throughput

0.479

High

912322

UB2E3
Ubiquitin-conjugating enzyme E2 E3

1

0

High-throughput

0.458

High

1000071

NOS3
Nitric oxide synthase 3

1

0

High-throughput

0.458

High

1222667

FBXW5
F-box/WD repeat-containing protein 5

1

0

High-throughput

0.458

High

107481

F8WJD6
Mex3 RNA binding family member B

1

2

High-throughput

0.437

High

788387

PPM1B
Protein phosphatase 1B

1

1

High-throughput

0.437

High

931630

RD23A
UV excision repair protein RAD23 homolog A

1

3

High-throughput

0.437

High

962886

NAA20
N-alpha-acetyltransferase 20

1

2

High-throughput

0.437

High

1189405

UBP39
Ubiquitin carboxyl-terminal hydrolase 39

1

10

High-throughput

0.437

High

1222172

GBB3
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3

1

3

High-throughput

0.437

High

1222621

AR13B
ADP-ribosylation factor-like protein 13B

1

3

High-throughput

0.437

High

1222626

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

4

High-throughput

0.437

High

1222628

TTC28
Tetratricopeptide repeat protein 28

1

4

High-throughput

0.437

High

1222632

CDC23
Cell division cycle protein 23 homolog

1

3

High-throughput

0.437

High

1222634

PEX5R
PEX5-related protein

1

2

High-throughput

0.437

High

1222636

UBP45
Ubiquitin carboxyl-terminal hydrolase 45

1

17

High-throughput

0.437

High

1222640

DUS18
Dual specificity protein phosphatase 18

1

3

High-throughput

0.437

High

1222646

2ABD
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform

1

4

High-throughput

0.437

High

1222653

KLH35
Kelch-like protein 35

1

2

High-throughput

0.437

High

1222656

DUS26
Dual specificity protein phosphatase 26

1

3

High-throughput

0.437

High

1222659

FBX3
F-box only protein 3

1

2

High-throughput

0.437

High

1222660

FXL12
F-box/LRR-repeat protein 12

1

2

High-throughput

0.437

High

1222663

SKI8
Superkiller complex protein 8

1

1

High-throughput

0.437

High

1222673

CHIP
E3 ubiquitin-protein ligase CHIP

1

2

High-throughput

0.437

High

1222674

SEC12
Guanine nucleotide-exchange factor SEC12

1

3

High-throughput

0.437

High

991281

RSMN
Small nuclear ribonucleoprotein-associated protein N

1

0

High-throughput

0.249

Low

1222627

2AAB
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform

1

0

High-throughput

0.249

Low

1222631

DCA12
DDB1- and CUL4-associated factor 12

1

0

High-throughput

0.249

Low

1222633

FBX44
F-box only protein 44

1

0

High-throughput

0.249

Low

1222675

MPP2
MAGUK p55 subfamily member 2

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025