Protein: TGFR2
TGF-beta receptor type-2 (TGFR-2) (EC 2.7.11.30) (TGF-beta type II receptor) (Transforming growth factor-beta receptor type II) (TGF-beta receptor type II) (TbetaR-II)

Gene: TGFR2, Tgfbr2
Organism: Mus musculus
Interactions: 91
UniProt ID: Q62312

Gene Ontology (top 5):
GO:0001569 - branching involved in blood vessel morphogenesis
GO:0001570 - vasculogenesis
GO:0001701 - in utero embryonic development
GO:0001837 - epithelial to mesenchymal transition
GO:0001947 - heart looping

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1223989

TGFR1
TGF-beta receptor type-1

4

18

Small-scale

0.873

High

1223469

M3K7
Mitogen-activated protein kinase kinase kinase 7

3

20

Small-scale

0.827

High

1022221

SHC1
SHC-transforming protein 1

1

11

Small-scale

0.690

High

50047

MELT
Ventricular zone-expressed PH domain-containing protein 1

1

1

High-throughput

0.618

High

109230

G5E884
non-specific serine/threonine protein kinase

1

5

High-throughput

0.618

High

148746

MP2K3
Dual specificity mitogen-activated protein kinase kinase 3

1

6

High-throughput

0.618

High

266586

AURKB
Aurora kinase B

1

3

High-throughput

0.618

High

312155

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

7

High-throughput

0.618

High

867737

WEE1
Wee1-like protein kinase

1

2

High-throughput

0.618

High

946716

RIPK2
Receptor-interacting serine/threonine-protein kinase 2

1

20

High-throughput

0.618

High

989413

RHES
GTP-binding protein Rhes

1

5

High-throughput

0.618

High

1000403

RIT1
GTP-binding protein Rit1

1

6

High-throughput

0.618

High

1021193

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.618

High

1222619

ACVL1
Activin receptor type-1-like

1

19

Small-scale

0.618

High

1223370

MELK
Maternal embryonic leucine zipper kinase

1

2

High-throughput

0.618

High

1223990

OXSR1
Serine/threonine-protein kinase OSR1

1

12

High-throughput

0.618

High

1223995

IRAK2
Interleukin-1 receptor-associated kinase-like 2

1

19

High-throughput

0.618

High

1223998

RAB38
Ras-related protein Rab-38

1

3

High-throughput

0.618

High

1223999

DAPK2
Death-associated protein kinase 2

1

2

High-throughput

0.618

High

1224003

Q91XL1
Leucine-rich HEV glycoprotein

1

20

Small-scale

0.618

High

1224018

REBL1
GTPase RhebL1

1

5

High-throughput

0.618

High

1224025

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.618

High

1224026

RGPS2
Ras-specific guanine nucleotide-releasing factor RalGPS2

1

1

High-throughput

0.618

High

1224028

KC1E
Casein kinase I isoform epsilon

1

4

High-throughput

0.618

High

1224032

E2AK4
eIF-2-alpha kinase GCN2

1

3

High-throughput

0.618

High

1224035

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

8

High-throughput

0.618

High

1224036

STK11
Serine/threonine-protein kinase STK11

1

3

High-throughput

0.618

High

1224037

RAB25
Ras-related protein Rab-25

1

3

High-throughput

0.618

High

1224013

TSSK4
Testis-specific serine/threonine-protein kinase 4

1

0

High-throughput

0.586

High

960639

RAB6B
Ras-related protein Rab-6B

1

11

High-throughput

0.553

High

1050619

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.553

High

1066075

RASLC
Ras-like protein family member 12

1

6

High-throughput

0.553

High

1223997

ARHG6
Rho guanine nucleotide exchange factor 6

1

3

High-throughput

0.553

High

1224006

Q99K94
Signal transducer and activator of transcription

1

3

High-throughput

0.553

High

1224027

PKHO1
Pleckstrin homology domain-containing family O member 1

1

1

High-throughput

0.553

High

1224029

PKHB1
Pleckstrin homology domain-containing family B member 1

1

1

High-throughput

0.553

High

312204

TGBR3
Transforming growth factor beta receptor type 3

1

12

Small-scale

0.479

High

554297

RAPSN
43 kDa receptor-associated protein of the synapse

1

4

High-throughput

0.479

High

651537

CBL
E3 ubiquitin-protein ligase CBL

1

2

Small-scale

0.479

High

693461

GNA12
Guanine nucleotide-binding protein subunit alpha-12

1

3

High-throughput

0.479

High

937531

CADH5
Cadherin-5

1

9

Small-scale

0.479

High

968115

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

7

High-throughput

0.479

High

968504

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

7

High-throughput

0.479

High

977636

PP2AB
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

1

6

High-throughput

0.479

High

984356

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

2

High-throughput

0.479

High

991003

UBE2B
Ubiquitin-conjugating enzyme E2 B

1

1

High-throughput

0.479

High

1000415

IRF7
Interferon regulatory factor 7

1

1

High-throughput

0.479

High

1188222

STING
Stimulator of interferon genes protein

1

1

High-throughput

0.479

High

1222173

GBB3
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3

1

3

High-throughput

0.479

High

1223988

EGLN
Endoglin

1

12

Small-scale

0.479

High

1223991

BCR
Breakpoint cluster region protein

1

1

High-throughput

0.479

High

1224000

WDR13
WD repeat-containing protein 13

1

2

High-throughput

0.479

High

1224001

WWOX
WW domain-containing oxidoreductase

1

1

High-throughput

0.479

High

1224007

ARL4D
ADP-ribosylation factor-like protein 4D

1

5

High-throughput

0.479

High

1224009

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

19

High-throughput

0.479

High

1224010

ARHGP
Rho guanine nucleotide exchange factor 25

1

3

High-throughput

0.479

High

1224012

ELP3
Elongator complex protein 3

1

1

High-throughput

0.479

High

1224019

AP2B1
AP-2 complex subunit beta

1

8

High-throughput

0.479

High

1224023

WWTR1
WW domain-containing transcription regulator protein 1

1

20

High-throughput

0.479

High

1224033

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

10

High-throughput

0.479

High

1224039

PAR6A
Partitioning defective 6 homolog alpha

1

4

High-throughput

0.479

High

1223992

Q6PFE1
Kelch-like 5

1

0

High-throughput

0.458

High

1224002

PODO
Podocin

1

0

Small-scale

0.458

High

148572

PEX5
Peroxisomal targeting signal 1 receptor

1

2

High-throughput

0.437

High

662009

NFYA
Nuclear transcription factor Y subunit alpha

1

1

Small-scale

0.437

High

931631

RD23A
UV excision repair protein RAD23 homolog A

1

3

High-throughput

0.437

High

946391

BTBD1
BTB/POZ domain-containing protein 1

1

1

High-throughput

0.437

High

962887

NAA20
N-alpha-acetyltransferase 20

1

2

High-throughput

0.437

High

1189406

UBP39
Ubiquitin carboxyl-terminal hydrolase 39

1

10

High-throughput

0.437

High

1190745

ELF3
ETS-related transcription factor Elf-3

1

2

Small-scale

0.437

High

1223993

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

4

High-throughput

0.437

High

1223994

CDC23
Cell division cycle protein 23 homolog

1

3

High-throughput

0.437

High

1223996

UBP45
Ubiquitin carboxyl-terminal hydrolase 45

1

17

High-throughput

0.437

High

1224004

UBXN1
UBX domain-containing protein 1

1

2

High-throughput

0.437

High

1224005

2ABD
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform

1

4

High-throughput

0.437

High

1224008

LZTR1
Leucine-zipper-like transcriptional regulator 1

1

2

High-throughput

0.437

High

1224011

KLH35
Kelch-like protein 35

1

2

High-throughput

0.437

High

1224015

ARL5B
ADP-ribosylation factor-like protein 5B

1

2

High-throughput

0.437

High

1224016

SYJ2B
Synaptojanin-2-binding protein

1

4

High-throughput

0.437

High

1224017

DUS26
Dual specificity protein phosphatase 26

1

3

High-throughput

0.437

High

1224020

KLC4
Kinesin light chain 4

1

2

High-throughput

0.437

High

1224021

DCAF6
DDB1- and CUL4-associated factor 6

1

5

High-throughput

0.437

High

1224022

FBX3
F-box only protein 3

1

2

High-throughput

0.437

High

1224024

FXL12
F-box/LRR-repeat protein 12

1

2

High-throughput

0.437

High

1224030

DNJC7
DnaJ homolog subfamily C member 7

1

4

High-throughput

0.437

High

1224031

DS13B
Dual specificity protein phosphatase 13B

1

3

High-throughput

0.437

High

1224034

TBL2
Transducin beta-like protein 2

1

2

High-throughput

0.437

High

1224038

SEC12
Guanine nucleotide-exchange factor SEC12

1

3

High-throughput

0.437

High

204434

OPSX
Visual pigment-like receptor peropsin

1

0

High-throughput

0.249

Low

1000219

FRAT1
Proto-oncogene FRAT1

1

0

High-throughput

0.249

Low

1224014

FBX24
F-box only protein 24

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025