HitPredict

Interactor 1: BMR1B (O00238)
Bone morphogenetic protein receptor type-1B (BMP type-1B receptor) (BMPR-1B) (EC 2.7.11.30) (CD antigen CDw293)
Gene: BMPR1B

Interactor 2: GDF6 (Q6KF10)
Growth/differentiation factor 6 (GDF-6) (Bone morphogenetic protein 13) (BMP-13) (Growth/differentiation factor 16)
Gene: GDF6

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	9525338
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Activin_recp~TGF_beta
Common GO terms	GO:0030509 - BMP signaling pathway GO:0032332 - positive regulation of chondrocyte differentiation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 502 Hs			1 455
+	Hs
		738359 BMR1A_HUMAN (8-502): 2.33e-139: 413: 71.63		GDF6_HUMAN (1-455): 1.79e-156: 452: 100.00
+	Hs
		122281 BMR1B_HUMAN (1-502): 2.91e-155: 453: 100.00		BMP4_HUMAN (78-455): 1.22e-99: 306: 27.07
+	Hs
		122282 BMR1B_HUMAN (1-502): 2.91e-155: 453: 100.00		BMP7_HUMAN (80-454): 6.35e-97: 300: 24.08
+	Hs
		122285 BMR1B_HUMAN (1-502): 2.91e-155: 453: 100.00		GDF5_HUMAN (21-455): 5.17e-96: 299: 41.79
+	Hs
		122283 BMR1B_HUMAN (1-502): 2.91e-155: 453: 100.00		BMP6_HUMAN (50-454): 1.32e-94: 296: 23.08
+	Hs
		122280 BMR1B_HUMAN (1-502): 2.91e-155: 453: 100.00		BMP2_HUMAN (78-455): 2.2e-90: 281: 26.01
+	Hs
		520110 BMR1A_HUMAN (8-502): 2.33e-139: 413: 71.63		BMP4_HUMAN (78-455): 1.22e-99: 306: 27.07
+	Hs
		574186 BMR1A_HUMAN (8-502): 2.33e-139: 413: 71.63		BMP7_HUMAN (80-454): 6.35e-97: 300: 24.08
+	Hs
		738309 BMR1A_HUMAN (8-502): 2.33e-139: 413: 71.63		GDF5_HUMAN (21-455): 5.17e-96: 299: 41.79
+	Hs
		602926 BMR1A_HUMAN (8-502): 2.33e-139: 413: 71.63		BMP6_HUMAN (50-454): 1.32e-94: 296: 23.08
+	Dm
		429971 Q24326_DROME (6-502): 7.7e-140: 415: 47.98		DECA_DROME (24-455): 2.1e-92: 293: 24.55
+	Dm
		429972 Q7JQ36_DROME (1-499): 2.66e-138: 412: 41.60		DECA_DROME (24-455): 2.1e-92: 293: 24.55
+	Hs
		520071 BMR1A_HUMAN (8-502): 2.33e-139: 413: 71.63		BMP2_HUMAN (78-455): 2.2e-90: 281: 26.01
+	Dm
		646113 Q24326_DROME (6-502): 7.7e-140: 415: 47.98		60A_DROME (99-454): 7.68e-86: 271: 23.55
+	Dm
		871199 Q7JQ36_DROME (1-499): 2.66e-138: 412: 41.60		SCW_DROME (23-454): 1.53e-83: 264: 20.73
+	Hs
		439885 ACVR1_HUMAN (19-499): 1.01e-138: 411: 49.70		INHBA_HUMAN (14-454): 4.51e-80: 256: 22.80
+	Hs
		495651 TGFR1_HUMAN (31-502): 9.48e-139: 411: 53.14		TGFB3_HUMAN (43-454): 8.21e-79: 252: 18.52
+	Hs
		351286 BMR1A_HUMAN (8-502): 2.33e-139: 413: 71.63		TGFB1_HUMAN (41-454): 4.82e-78: 249: 19.72
+	Hs
		351287 TGFR1_HUMAN (31-502): 9.48e-139: 411: 53.14		TGFB1_HUMAN (41-454): 4.82e-78: 249: 19.72
+	Hs
		738518 TGFR1_HUMAN (31-502): 9.48e-139: 411: 53.14		TGFB2_HUMAN (43-454): 2.14e-75: 243: 18.27