Protein: ROCK1
Rho-associated protein kinase 1 (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-35) (Rho-associated, coiled-coil-containing protein kinase 1) (Rho-associated, coiled-coil-containing protein kinase I) (ROCK-I) (p160 ROCK-1) (p160ROCK)

Gene: ROCK1
Organism: Homo sapiens
Interactions: 139
UniProt ID: Q13464

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0000281 - mitotic cytokinesis
GO:0001726 - ruffle
GO:0001837 - epithelial to mesenchymal transition
GO:0003180 - aortic valve morphogenesis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

962019

RHOA
Transforming protein RhoA

7

20

Small-scale

0.966

High

270804

ROCK2
Rho-associated protein kinase 2

3

19

High-throughput

0.861

High

977984

RHOB
Rho-related GTP-binding protein RhoB

3

20

Small-scale

0.834

High

922306

LIMK2
LIM domain kinase 2

2

9

Small-scale

0.812

High

373912

RASN
GTPase NRas

2

20

High-throughput

0.754

High

374571

RASH
GTPase HRas

2

20

High-throughput

0.754

High

375488

RASK
GTPase KRas

2

20

High-throughput

0.754

High

466240

RHOC
Rho-related GTP-binding protein RhoC

2

20

Small-scale

0.754

High

531061

KAP0
cAMP-dependent protein kinase type I-alpha regulatory subunit

2

4

High-throughput

0.737

High

631202

RAB5A
Ras-related protein Rab-5A

2

8

High-throughput

0.737

High

1015417

RHOG
Rho-related GTP-binding protein RhoG

2

20

Small-scale

0.737

High

191908

MAGB4
Melanoma-associated antigen B4

4

5

High-throughput

0.705

High

854432

KPB2
Phosphorylase b kinase regulatory subunit alpha, liver isoform

1

1

High-throughput

0.691

High

857445

NOTC1
Neurogenic locus notch homolog protein 1

1

5

High-throughput

0.691

High

1106271

TENS2
Tensin-2

1

5

High-throughput

0.691

High

1106283

ZBTB2
Zinc finger and BTB domain-containing protein 2

1

4

High-throughput

0.691

High

1098217

MYBPH
Myosin-binding protein H

1

7

Small-scale

0.648

High

167889

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

20

Small-scale

0.647

High

719138

MPIP1
M-phase inducer phosphatase 1

1

1

Small-scale

0.647

High

962732

RND3
Rho-related GTP-binding protein RhoE

1

20

Small-scale

0.647

High

1106259

ROCK1
Rho-associated protein kinase 1

1

16

Small-scale

0.647

High

774145

ADDB
Beta-adducin

2

5

High-throughput

0.628

High

1106286

ANR49
Ankyrin repeat domain-containing protein 49

1

5

High-throughput

0.618

High

126579

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.618

High

318761

RHBT1
Rho-related BTB domain-containing protein 1

1

20

Small-scale

0.618

High

411879

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.618

High

463506

LYN
Tyrosine-protein kinase Lyn

1

20

High-throughput

0.618

High

485118

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

17

High-throughput

0.618

High

541469

FGFR1
Fibroblast growth factor receptor 1

1

20

High-throughput

0.618

High

581026

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.618

High

601274

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.618

High

710224

EPHA2
Ephrin type-A receptor 2

1

13

High-throughput

0.618

High

710826

EPHB2
Ephrin type-B receptor 2

1

9

High-throughput

0.618

High

830687

CCNF
Cyclin-F

1

3

High-throughput

0.618

High

845629

MUC18
Cell surface glycoprotein MUC18

1

11

High-throughput

0.618

High

936316

AFAD
Afadin

1

20

High-throughput

0.618

High

953428

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.618

High

955133

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.618

High

956280

RAB2A
Ras-related protein Rab-2A

1

10

High-throughput

0.618

High

988339

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.618

High

1106267

RAB35
Ras-related protein Rab-35

1

10

High-throughput

0.618

High

1106268

RHOH
Rho-related GTP-binding protein RhoH

1

20

High-throughput

0.618

High

1106270

CDKN3
Cyclin-dependent kinase inhibitor 3

1

2

Small-scale

0.618

High

1106275

TRI67
Tripartite motif-containing protein 67

1

17

High-throughput

0.618

High

1106281

RTKN2
Rhotekin-2

1

3

High-throughput

0.618

High

1106293

CDK15
Cyclin-dependent kinase 15

1

8

High-throughput

0.618

High

1106301

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.618

High

1106302

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.618

High

1106303

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.618

High

1106307

ANLN
Anillin

1

3

High-throughput

0.618

High

540439

LAMP1
Lysosome-associated membrane glycoprotein 1

2

7

High-throughput

0.584

High

468338

HS90B
Heat shock protein HSP 90-beta

1

20

Small-scale

0.575

High

620344

NUCL
Nucleolin

1

10

Small-scale

0.575

High

1106260

GAB1
GRB2-associated-binding protein 1

1

6

Small-scale

0.575

High

1106298

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

1

High-throughput

0.573

High

702346

ELK4
ETS domain-containing protein Elk-4

2

1

High-throughput

0.571

High

878450

PAXI
Paxillin

2

7

High-throughput

0.571

High

630791

RAB4A
Ras-related protein Rab-4A

1

10

High-throughput

0.553

High

1106295

TS101
Tumor susceptibility gene 101 protein

1

0

Small-scale

0.549

High

559341

XRCC5
X-ray repair cross-complementing protein 5

1

3

High-throughput

0.536

High

777273

AHR
Aryl hydrocarbon receptor

1

4

High-throughput

0.536

High

882479

ARRB1
Beta-arrestin-1

1

3

High-throughput

0.536

High

964606

DCAF7
DDB1- and CUL4-associated factor 7

1

11

High-throughput

0.536

High

1013367

HTRA3
Serine protease HTRA3

1

3

High-throughput

0.536

High

1106261

SMAD4
Mothers against decapentaplegic homolog 4

1

6

High-throughput

0.536

High

1106284

BBS1
BBSome complex member BBS1

1

2

High-throughput

0.536

High

1106288

HDAC2
Histone deacetylase 2

1

10

High-throughput

0.536

High

1106289

VPP1
V-type proton ATPase 116 kDa subunit a 1

1

1

High-throughput

0.536

High

1106300

SPRTN
DNA-dependent metalloprotease SPRTN

1

1

High-throughput

0.536

High

1106311

I20RA
Interleukin-20 receptor subunit alpha

1

4

High-throughput

0.536

High

681808

RBTN2
Rhombotin-2

1

4

High-throughput

0.523

High

1106276

FRMD5
FERM domain-containing protein 5

1

7

Small-scale

0.515

High

1106285

NEIL3
Endonuclease 8-like 3

1

0

High-throughput

0.513

High

1106290

APC16
Anaphase-promoting complex subunit 16

1

0

High-throughput

0.513

High

1106312

MED23
Mediator of RNA polymerase II transcription subunit 23

1

0

High-throughput

0.513

High

687235

HMGB2
High mobility group protein B2

1

13

Small-scale

0.508

High

1106269

SMAD2
Mothers against decapentaplegic homolog 2

1

5

High-throughput

0.508

High

840050

CASP3
Caspase-3

1

4

Small-scale

0.501

High

936908

CASP7
Caspase-7

1

4

Small-scale

0.501

High

1106294

SMAD5
Mothers against decapentaplegic homolog 5

1

5

Small-scale

0.501

High

1106305

UBE2T
Ubiquitin-conjugating enzyme E2 T

1

4

Small-scale

0.501

High

653298

HEMH
Ferrochelatase, mitochondrial

1

2

High-throughput

0.489

High

1106272

KDM4D
Lysine-specific demethylase 4D

1

3

High-throughput

0.489

High

1106291

CERS2
Ceramide synthase 2

1

2

High-throughput

0.489

High

1106308

MED17
Mediator of RNA polymerase II transcription subunit 17

1

1

High-throughput

0.489

High

1106299

TRI15
E3 ubiquitin-protein ligase TRIM15

1

8

Small-scale

0.481

High

1106309

ITSN2
Intersectin-2

1

6

High-throughput

0.481

High

317519

TPPP
Tubulin polymerization-promoting protein

1

0

Small-scale

0.480

High

1106266

MLC1
Membrane protein MLC1

1

0

Small-scale

0.480

High

130742

TAF4
Transcription initiation factor TFIID subunit 4

1

7

High-throughput

0.479

High

259905

BRD4
Bromodomain-containing protein 4

1

8

High-throughput

0.479

High

293655

CD123
Translation initiation factor eIF2 assembly protein

1

2

High-throughput

0.479

High

299178

FLOT1
Flotillin-1

1

7

High-throughput

0.479

High

316840

MTA2
Metastasis-associated protein MTA2

1

4

High-throughput

0.479

High

319740

UFL1
E3 UFM1-protein ligase 1

1

2

High-throughput

0.479

High

413774

P53
Cellular tumor antigen p53

1

6

High-throughput

0.479

High

437161

K2C8
Keratin, type II cytoskeletal 8

1

3

High-throughput

0.479

High

487272

PARP1
Poly [ADP-ribose] polymerase 1

1

6

High-throughput

0.479

High

537106

HSP7C
Heat shock cognate 71 kDa protein

1

13

High-throughput

0.479

High

552574

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

1

2

High-throughput

0.479

High

562042

LAMP2
Lysosome-associated membrane glycoprotein 2

1

7

High-throughput

0.479

High

580627

AMPN
Aminopeptidase N

1

1

High-throughput

0.479

High

591295

CD44
CD44 antigen

1

2

Small-scale

0.479

High

624632

SL9A1
Sodium/hydrogen exchanger 1

1

4

Small-scale

0.479

High

642850

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

4

High-throughput

0.479

High

660054

COF1
Cofilin-1

1

6

Small-scale

0.479

High

692953

DPP4
Dipeptidyl peptidase 4

1

2

High-throughput

0.479

High

762452

PROF2
Profilin-2

1

1

Small-scale

0.479

High

772782

MYH9
Myosin-9

1

5

Small-scale

0.479

High

957357

UBC12
NEDD8-conjugating enzyme Ubc12

1

3

High-throughput

0.479

High

970453

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

6

High-throughput

0.479

High

971486

1433E
14-3-3 protein epsilon

1

3

Small-scale

0.479

High

975019

ARF6
ADP-ribosylation factor 6

1

7

High-throughput

0.479

High

1031359

IFM3
Interferon-induced transmembrane protein 3

1

1

High-throughput

0.479

High

1067280

EP300
Histone acetyltransferase p300

1

14

High-throughput

0.479

High

1106262

CUL3
Cullin-3

1

6

High-throughput

0.479

High

1106263

CUL4A
Cullin-4A

1

6

High-throughput

0.479

High

1106264

DCTN1
Dynactin subunit 1

1

12

High-throughput

0.479

High

1106273

LTOR1
Ragulator complex protein LAMTOR1

1

2

High-throughput

0.479

High

1106277

TM11B
Transmembrane protease serine 11B

1

8

High-throughput

0.479

High

1106279

CHERP
Calcium homeostasis endoplasmic reticulum protein

1

6

High-throughput

0.479

High

1106292

SNX27
Sorting nexin-27

1

20

High-throughput

0.479

High

1106296

ANM1
Protein arginine N-methyltransferase 1

1

4

High-throughput

0.479

High

1106304

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

7

High-throughput

0.479

High

1106306

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

5

High-throughput

0.479

High

1106310

ZRAN1
Ubiquitin thioesterase ZRANB1

1

12

High-throughput

0.479

High

1106313

MYO6
Unconventional myosin-VI

1

7

High-throughput

0.479

High

1106314

LAMP3
Lysosome-associated membrane glycoprotein 3

1

7

High-throughput

0.479

High

1106315

ARIP4
Helicase ARIP4

1

7

High-throughput

0.479

High

1106265

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

High-throughput

0.458

High

1106297

RNZ2
Zinc phosphodiesterase ELAC protein 2

1

0

High-throughput

0.458

High

635525

NEBU
Nebulin

1

8

Small-scale

0.445

High

105876

APRIO
Alternative prion protein

1

4

High-throughput

0.437

High

1106274

FBX42
F-box only protein 42

1

3

High-throughput

0.437

High

1106287

EDEM1
ER degradation-enhancing alpha-mannosidase-like protein 1

1

1

High-throughput

0.437

High

1106278

F124A
Protein FAM124A

1

0

High-throughput

0.299

High

1106280

CF206
Cilia- and flagella-associated protein 206

1

0

High-throughput

0.299

High

1106282

SYCE1
Synaptonemal complex central element protein 1

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025