HitPredict

Interactor 1: CSN5A (Q8LAZ7)
COP9 signalosome complex subunit 5a (Signalosome subunit 5a) (EC 3.4.-.-) (Jun activation domain-binding homolog 1)
Gene: CSN5A

Interactor 2: CSN3 (Q8W575)
COP9 signalosome complex subunit 3 (Signalosome subunit 3) (Protein FUSCA 11)
Gene: CSN3

Species: Arabidopsis thaliana

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	1.00	0.835

Property	Details
Experiments	15486099, 11742986, 15703063
Identification Methods	affinity chromatography technology, two hybrid, tandem affinity purification
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	JAB~PCI
Common GO terms	GO:0000338 - protein deneddylation GO:0005737 - cytoplasm GO:0008180 - COP9 signalosome GO:0009585 - red, far-red light phototransduction GO:0010971 - positive regulation of G2/M transition of mitotic cell cycle
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 357 At			1 429
+	At
		1259203 CSN5B_ARATH (1-356): 1.45e-134: 389: 85.71		CSN3_ARATH (1-429): 4.41e-134: 393: 100.00
+	Hs
		1272703 CSN5_HUMAN (1-338): 6.45e-123: 359: 65.09		CSN3_HUMAN (6-428): 3.09e-116: 347: 37.76
+	Zm
		46755 B4FLQ8_MAIZE (37-312): 2.18e-82: 254: 29.10		A0A3L6E9W8_MAIZE (5-427): 1.64e-129: 383: 51.39
+	At
		1227249 CSN5A_ARATH (1-357): 2.09e-139: 401: 100.00		CSN2_ARATH (30-381): 1.92e-64: 215: 9.92
+	At
		1258867 CSN5B_ARATH (1-356): 1.45e-134: 389: 85.71		CSN2_ARATH (30-381): 1.92e-64: 215: 9.92
+	Dm
		1277039 CSN5_DROME (6-342): 6.46e-129: 373: 63.80		CSN2_DROME (36-384): 4.86e-68: 224: 12.09
+	Mm
		193516 CSN5_MOUSE (1-338): 4.4e-123: 359: 65.09		CSN2_MOUSE (33-384): 4.6e-73: 237: 11.17
+	Hs
		897288 CSN5_HUMAN (1-338): 6.45e-123: 359: 65.09		CSN2_HUMAN (33-384): 4.6e-73: 237: 11.17
+	Ce
		954227 CSN5_CAEEL (5-354): 7.71e-116: 342: 52.57		CSN3_CAEEL (2-428): 3e-77: 250: 17.28
+	Ce
		136314 CSN5_CAEEL (5-354): 7.71e-116: 342: 52.57		CSN2_CAEEL (30-366): 1.13e-71: 235: 12.46
+	Dm
		627132 PSDE_DROME (42-312): 2.1e-83: 257: 33.33		PSMD3_DROME (8-420): 9.69e-100: 308: 19.72
+	An
		1124306 CSN5_EMENI (8-342): 1.28e-108: 322: 51.63		CSN3_EMENI (5-412): 5.91e-73: 238: 20.09
+	An
		1124314 CSN5_EMENI (8-342): 1.28e-108: 322: 51.63		CSN2_EMENI (37-374): 8.1e-70: 230: 12.43
+	Hs
		130648 PSDE_HUMAN (49-312): 3.09e-81: 251: 32.98		PSMD3_HUMAN (47-424): 2.86e-96: 300: 20.51
+	Dm
		1358216 CSN5_DROME (6-342): 6.46e-129: 373: 63.80		CSN4_DROME (72-396): 5.67e-44: 159: 11.44
+	Dm
		1180711 PSDE_DROME (42-312): 2.1e-83: 257: 33.33		PSD11_DROME (55-394): 6.36e-79: 252: 13.16
+	Hs
		121632 PSDE_HUMAN (49-312): 3.09e-81: 251: 32.98		PSD11_HUMAN (55-393): 6.12e-81: 257: 13.19
+	Sc
		766863 RPN11_YEAST (37-311): 1e-76: 240: 30.41		RPN3_YEAST (49-418): 1.79e-76: 248: 16.54
+	Sp
		293445 CSN5_SCHPO (30-336): 3.24e-89: 271: 40.26		CSN2_SCHPO (53-386): 9.38e-52: 181: 9.77
+	Sc
		797651 RPN11_YEAST (37-311): 1e-76: 240: 30.41		RPN6_YEAST (51-386): 1.27e-62: 210: 12.11