HitPredict

Interactor 1: CSN5A (Q8LAZ7)
COP9 signalosome complex subunit 5a (Signalosome subunit 5a) (EC 3.4.-.-) (Jun activation domain-binding homolog 1)
Gene: CSN5A

Interactor 2: CSN7 (Q94JU3)
COP9 signalosome complex subunit 7 (CSN complex subunit 7) (Protein FUSCA 5)
Gene: CSN7

Species: Arabidopsis thaliana

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.775

Property	Details
Experiments	11742986, 15486099
Identification Methods	two hybrid, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	JAB~PCI
Common GO terms	GO:0000338 - protein deneddylation GO:0005737 - cytoplasm GO:0008180 - COP9 signalosome GO:0009585 - red, far-red light phototransduction GO:0010387 - COP9 signalosome assembly
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 357 At			1 260
+	At
		1278363 CSN5B_ARATH (1-356): 1.45e-134: 389: 85.71		CSN7_ARATH (1-260): 4.96e-98: 288: 100.00
+	Dm
		1359992 CSN5_DROME (6-342): 6.46e-129: 373: 63.80		CSN7_DROME (2-257): 6.25e-81: 246: 32.56
+	Hs
		1272616 CSN5_HUMAN (1-338): 6.45e-123: 359: 65.09		CSN7B_HUMAN (1-255): 1.99e-79: 241: 32.56
+	Mm
		193524 CSN5_MOUSE (1-338): 4.4e-123: 359: 65.09		CSN7B_MOUSE (1-255): 1.53e-78: 239: 32.56
+	Hs
		1272670 CSN5_HUMAN (1-338): 6.45e-123: 359: 65.09		CSN7A_HUMAN (12-255): 1.4e-75: 232: 30.28
+	At
		1278361 EIF3H_ARATH (40-349): 2.68e-82: 255: 15.39		CSN7_ARATH (1-260): 4.96e-98: 288: 100.00
+	Hs
		1272702 CSN5_HUMAN (1-338): 6.45e-123: 359: 65.09		PSD13_HUMAN (16-191): 1.36e-54: 181: 17.20
+	Ce
		954221 CSN5_CAEEL (5-354): 7.71e-116: 342: 52.57		EIF3M_CAEEL (2-216): 1.3e-44: 156: 19.73
+	An
		961359 CSN5_EMENI (8-342): 1.28e-108: 322: 51.63		CSN7_EMENI (1-221): 8.33e-44: 152: 30.00
+	Hs
		177046 EIF3H_HUMAN (51-350): 7.18e-84: 260: 16.89		EIF3M_HUMAN (2-188): 3.07e-54: 181: 22.17
+	Hs
		131110 PSDE_HUMAN (49-312): 3.09e-81: 251: 32.98		PSD13_HUMAN (16-191): 1.36e-54: 181: 17.20
+	Dm
		1180994 PSDE_DROME (42-312): 2.1e-83: 257: 33.33		Q7KMP8_DROME (24-191): 1.43e-51: 174: 20.23
+	Dm
		1177352 EIF3H_DROME (41-350): 2.31e-78: 245: 17.63		EIF3M_DROME (3-205): 2.2e-53: 179: 21.70
+	Hs
		131124 PSDE_HUMAN (49-312): 3.09e-81: 251: 32.98		Q9Y6E3_HUMAN (16-191): 1.97e-47: 163: 16.58
+	Ce
		284027 PSDE_CAEEL (49-312): 6.42e-75: 235: 30.85		Q22253_CAEEL (11-191): 7.45e-51: 172: 18.85
+	Sc
		797570 RPN11_YEAST (37-311): 1e-76: 240: 30.41		RPN9_YEAST (11-191): 1.48e-46: 161: 15.18
+	Sp
		784777 RPN11_SCHPO (37-310): 7.7e-76: 237: 29.87		RPN9_SCHPO (15-189): 7.89e-43: 151: 17.55
+	Hs
		849285 PSMD7_HUMAN (55-281): 1.01e-56: 189: 16.80		PSD13_HUMAN (16-191): 1.36e-54: 181: 17.20
+	Hs
		849293 PSMD7_HUMAN (55-281): 1.01e-56: 189: 16.80		Q9Y6E3_HUMAN (16-191): 1.97e-47: 163: 16.58
+	Sp
		999848 EIF3H_SCHPO (47-349): 2.27e-63: 207: 17.02		EIF3M_SCHPO (2-206): 4.96e-40: 144: 24.07