Protein: CD22
B-cell receptor CD22 (B-lymphocyte cell adhesion molecule) (BL-CAM) (Sialic acid-binding Ig-like lectin 2) (Siglec-2) (T-cell surface antigen Leu-14) (CD antigen CD22)

Gene: CD22
Organism: Homo sapiens
Interactions: 27
UniProt ID: P20273

Gene Ontology (top 5):
GO:0001791 - IgM binding
GO:0002638 - negative regulation of immunoglobulin production
GO:0005102 - signaling receptor binding
GO:0005737 - cytoplasm
GO:0005769 - early endosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

471721

PTPRC
Receptor-type tyrosine-protein phosphatase C

2

13

Small-scale

0.754

High

629541

PTN6
Tyrosine-protein phosphatase non-receptor type 6

5

20

Small-scale

0.722

High

629543

S10A7
Protein S100-A7

1

3

High-throughput

0.691

High

463325

LYN
Tyrosine-protein kinase Lyn

3

8

Small-scale

0.660

High

629547

GRB2
Growth factor receptor-bound protein 2

3

16

Small-scale

0.650

High

252276

TLR5
Toll-like receptor 5

1

20

Small-scale

0.618

High

628342

CD33
Myeloid cell surface antigen CD33

1

18

Small-scale

0.618

High

629539

CD22
B-cell receptor CD22

1

17

Small-scale

0.618

High

629545

MUC18
Cell surface glycoprotein MUC18

1

18

High-throughput

0.618

High

629553

TLR10
Toll-like receptor 10

1

20

Small-scale

0.618

High

629546

KSYK
Tyrosine-protein kinase SYK

2

18

Small-scale

0.612

High

629549

ANR46
Ankyrin repeat domain-containing protein 46

2

12

High-throughput

0.606

High

629554

TM140
Transmembrane protein 140

2

0

High-throughput

0.580

High

583962

CD19
B-lymphocyte antigen CD19

2

0

Small-scale

0.576

High

618969

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

1

4

Small-scale

0.554

High

563174

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

High-throughput

0.541

High

258587

SH21A
SH2 domain-containing protein 1A

1

20

Small-scale

0.515

High

629555

CBPA4
Carboxypeptidase A4

1

1

High-throughput

0.489

High

629551

AP2M1
AP-2 complex subunit mu

1

3

Small-scale

0.481

High

344623

AP2A1
AP-2 complex subunit alpha-1

1

5

Small-scale

0.479

High

629542

SHC1
SHC-transforming protein 1

1

13

Small-scale

0.479

High

629544

TIA1
Cytotoxic granule associated RNA binding protein TIA1

1

7

Small-scale

0.479

High

629550

SHIP1
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

1

6

Small-scale

0.479

High

629540

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

2

Small-scale

0.445

High

629548

A16L1
Autophagy-related protein 16-1

1

6

High-throughput

0.437

High

629552

NTAQ1
Protein N-terminal glutamine amidohydrolase

2

0

High-throughput

0.316

High


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Last updated: 11Aug2025