HitPredict

Interactor 1: LTBP4 (Q8N2S1)
Latent-transforming growth factor beta-binding protein 4 (LTBP-4)
Gene: LTBP4

Interactor 2: NELL1 (Q92832)
Protein kinase C-binding protein NELL1 (NEL-like protein 1) (Nel-related protein 1)
Gene: NELL1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	EGF_3~EGF_CA, EGF_CA~EGF_CA, EGF_CA~TB
Common GO terms	GO:0005509 - calcium ion binding GO:0005615 - extracellular space
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 1624 Hs			1 810
+	Hs
		1231800 LTBP4_HUMAN (1-1624): 0: 640: 100.00		NELL2_HUMAN (6-807): 3.09e-99: 328: 55.24
+	Hs
		1059076 LTBP4_HUMAN (1-1624): 0: 640: 100.00		LTBP2_HUMAN (265-692): 1.3e-22: 106: 20.12
+	Hs
		612884 LTBP4_HUMAN (1-1624): 0: 640: 100.00		FBLN1_HUMAN (390-628): 4.37e-12: 71.6: 29.64
+	Hs
		980445 LTBP4_HUMAN (1-1624): 0: 640: 100.00		NOTC2_HUMAN (151-576): 1.14e-11: 70.8: 11.44
+	Hs
		724347 LTBP4_HUMAN (1-1624): 0: 640: 100.00		FBN1_HUMAN (332-808): 8.56e-11: 68.1: 14.74
+	Hs
		1231807 LTBP4_HUMAN (1-1624): 0: 640: 100.00		FBLN5_HUMAN (414-636): 1.55e-10: 66.2: 25.94
+	Hs
		1357251 NOTC3_HUMAN (396-1624): 7.04e-107: 380: 16.83		JAG2_HUMAN (336-808): 1.18e-36: 151: 20.17
+	Hs
		944134 NOTC3_HUMAN (396-1624): 7.04e-107: 380: 16.83		JAG1_HUMAN (171-575): 8.57e-24: 110: 12.96
+	Hs
		1357250 NOTC3_HUMAN (396-1624): 7.04e-107: 380: 16.83		NOTC3_HUMAN (182-604): 5.96e-12: 72: 13.04
+	Hs
		612912 NOTC3_HUMAN (396-1624): 7.04e-107: 380: 16.83		FBLN1_HUMAN (390-628): 4.37e-12: 71.6: 29.64
+	Hs
		804372 NOTC3_HUMAN (396-1624): 7.04e-107: 380: 16.83		NOTC1_HUMAN (510-810): 1.08e-11: 71.2: 16.06
+	Hs
		980576 NOTC3_HUMAN (396-1624): 7.04e-107: 380: 16.83		NOTC2_HUMAN (151-576): 1.14e-11: 70.8: 11.44
+	Dr
		804160 NOTC1_DANRE (463-1624): 4.14e-95: 344: 17.18		Q1A5L1_DANRE (267-472): 2.28e-10: 66.5: 18.93
+	Dr
		804161 NOTC1_DANRE (463-1624): 4.14e-95: 344: 17.18		Q1A5L2_DANRE (602-808): 3.47e-10: 66.1: 18.96
+	Hs
		944119 NOTC2_HUMAN (16-812): 8.31e-50: 197: 14.64		JAG1_HUMAN (171-575): 8.57e-24: 110: 12.96
+	Hs
		612843 NOTC2_HUMAN (16-812): 8.31e-50: 197: 14.64		FBLN1_HUMAN (390-628): 4.37e-12: 71.6: 29.64
+	Hs
		804213 NOTC2_HUMAN (16-812): 8.31e-50: 197: 14.64		NOTC1_HUMAN (510-810): 1.08e-11: 71.2: 16.06
+	Hs
		724367 NOTC2_HUMAN (16-812): 8.31e-50: 197: 14.64		FBN2_HUMAN (249-810): 8.08e-11: 68.1: 12.81