HitPredict

Interactor 1: PALS1 (Q8N3R9)
Protein PALS1 (MAGUK p55 subfamily member 5) (Membrane protein, palmitoylated 5) (Protein associated with Lin-7 1)
Gene: PALS1

Interactor 2: LIN7C (Q9NUP9)
Protein lin-7 homolog C (Lin-7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3)
Gene: LIN7C

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.90	1.00	0.950

Property	Details
Experiments	26186194, 24366813, 28514442, 32296183, 33961781, unassigned1304
Identification Methods	affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	Guanylate_kin~PDZ, L27~L27, PDZ~PDZ, PDZ~SH3_2
Common GO terms	GO:0002011 - morphogenesis of an epithelial sheet GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0005923 - bicellular tight junction GO:0019904 - protein domain specific binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 675 Hs			1 197
+	Mm
		292498 PALS1_MOUSE (1-675): 0: 559: 96.74		LIN7C_MOUSE (1-197): 1.38e-57: 181: 100.00
+	Hs
		1232501 PALS1_HUMAN (1-675): 0: 561: 100.00		LIN7B_HUMAN (1-196): 4.81e-55: 175: 84.69
+	Hs
		158294 PALS1_HUMAN (1-675): 0: 561: 100.00		LIN7A_HUMAN (6-194): 4.87e-51: 166: 80.42
+	Hs
		1232511 PALS1_HUMAN (1-675): 0: 561: 100.00		SNTG2_HUMAN (28-188): 1.75e-32: 124: 25.77
+	Hs
		1232493 PALS1_HUMAN (1-675): 0: 561: 100.00		MPP4_HUMAN (16-174): 1.11e-30: 119: 28.30
+	Dm
		116476 M9PJD0_DROME (227-674): 2.22e-144: 464: 50.83		Q9VBY7_DROME (1-195): 1.45e-52: 168: 80.00
+	Hs
		280053 PALS1_HUMAN (1-675): 0: 561: 100.00		MPDZ_HUMAN (39-162): 6.77e-13: 68.6: 20.16
+	Hs
		1232484 PALS1_HUMAN (1-675): 0: 561: 100.00		INADL_HUMAN (112-194): 6.16e-11: 62.8: 30.12
+	Hs
		1232496 PALS1_HUMAN (1-675): 0: 561: 100.00		MAGI1_HUMAN (94-172): 5.41e-10: 60.1: 35.44
+	Hs
		1346107 PALS2_HUMAN (134-674): 6.92e-142: 426: 34.66		LIN7C_HUMAN (1-197): 1.38e-57: 181: 100.00
+	Hs
		1334778 PALS2_HUMAN (134-674): 6.92e-142: 426: 34.66		LIN7B_HUMAN (1-196): 4.81e-55: 175: 84.69
+	Dm
		1096800 CSKP_DROME (10-674): 4.78e-138: 428: 28.34		Q9VBY7_DROME (1-195): 1.45e-52: 168: 80.00
+	Hs
		158304 PALS2_HUMAN (134-674): 6.92e-142: 426: 34.66		LIN7A_HUMAN (6-194): 4.87e-51: 166: 80.42
+	Hs
		158254 CSKP_HUMAN (9-674): 7.61e-136: 423: 25.80		LIN7A_HUMAN (6-194): 4.87e-51: 166: 80.42
+	Hs
		159203 CSKP_HUMAN (9-674): 7.61e-136: 423: 25.80		SNTB2_HUMAN (61-179): 3e-32: 123: 35.25
+	Hs
		159110 CSKP_HUMAN (9-674): 7.61e-136: 423: 25.80		CSKP_HUMAN (13-194): 1.3e-30: 119: 20.53
+	Hs
		159207 CSKP_HUMAN (9-674): 7.61e-136: 423: 25.80		SNTB1_HUMAN (65-179): 5.68e-31: 119: 35.90
+	Hs
		159190 CSKP_HUMAN (9-674): 7.61e-136: 423: 25.80		DLG4_HUMAN (59-195): 2.19e-23: 98.7: 26.76
+	Hs
		159200 CSKP_HUMAN (9-674): 7.61e-136: 423: 25.80		DLG1_HUMAN (50-178): 8.31e-23: 97.1: 30.60
+	Hs
		159249 CSKP_HUMAN (9-674): 7.61e-136: 423: 25.80		DLG3_HUMAN (74-164): 2.8e-20: 89.8: 35.42