Protein: HXC8
Homeobox protein Hox-C8 (Homeobox protein Hox-3A)

Gene: HXC8, HOXC8
Organism: Homo sapiens
Interactions: 133
UniProt ID: P31273

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

725025

PBX1
Pre-B-cell leukemia transcription factor 1

3

20

Small-scale

0.843

High

256526

TBX19
T-box transcription factor TBX19

2

20

High-throughput

0.783

High

330057

VENTX
Homeobox protein VENTX

2

20

High-throughput

0.783

High

685112

PAX6
Paired box protein Pax-6

2

20

High-throughput

0.783

High

724911

HXD3
Homeobox protein Hox-D3

2

16

High-throughput

0.783

High

725026

PBX2
Pre-B-cell leukemia transcription factor 2

2

20

High-throughput

0.783

High

725028

MEOX1
Homeobox protein MOX-1

2

16

High-throughput

0.783

High

725030

LHX2
LIM/homeobox protein Lhx2

2

15

High-throughput

0.783

High

725037

PO6F2
POU domain, class 6, transcription factor 2

2

20

High-throughput

0.783

High

725109

PBX4
Pre-B-cell leukemia transcription factor 4

2

20

High-throughput

0.783

High

725119

LHX3
LIM/homeobox protein Lhx3

2

14

High-throughput

0.783

High

725120

HESX1
Homeobox expressed in ES cells 1

2

19

High-throughput

0.783

High

725126

TBX22
T-box transcription factor TBX22

2

20

High-throughput

0.783

High

725103

HES6
Transcription cofactor HES-6

1

7

High-throughput

0.691

High

725074

Q6FHY5
MEOX2 protein

1

17

High-throughput

0.665

High

703261

MSX1
Homeobox protein MSX-1

1

18

Small-scale

0.647

High

725031

DLX5
Homeobox protein DLX-5

1

19

Small-scale

0.647

High

725045

DLX2
Homeobox protein DLX-2

1

19

Small-scale

0.647

High

725125

JIP1
C-Jun-amino-terminal kinase-interacting protein 1

2

9

High-throughput

0.628

High

725029

MEOX2
Homeobox protein MOX-2

1

17

High-throughput

0.621

High

405828

MYCN
N-myc proto-oncogene protein

1

8

High-throughput

0.618

High

725049

JIP2
C-Jun-amino-terminal kinase-interacting protein 2

3

20

High-throughput

0.607

High

192064

PA2GX
Group 10 secretory phospholipase A2

2

1

High-throughput

0.606

High

217064

MS18B
Protein Mis18-beta

2

2

High-throughput

0.606

High

269151

HSF2B
Heat shock factor 2-binding protein

2

1

High-throughput

0.606

High

343739

LDOC1
Protein LDOC1

2

1

High-throughput

0.606

High

571881

TRI27
Zinc finger protein RFP

2

10

High-throughput

0.606

High

725039

PAX5
Paired box protein Pax-5

2

20

High-throughput

0.606

High

725043

PAX8
Paired box protein Pax-8

2

20

High-throughput

0.606

High

725047

TLE5
TLE family member 5

2

19

High-throughput

0.606

High

725054

TRIP6
Thyroid receptor-interacting protein 6

2

5

High-throughput

0.606

High

725070

MYOME
Myomegalin

2

1

High-throughput

0.606

High

725082

TBCD1
TBC1 domain family member 1

2

4

High-throughput

0.606

High

725094

IKBD
NF-kappa-B inhibitor delta

2

20

High-throughput

0.606

High

725095

ZFP90
Zinc finger protein 90 homolog

2

1

High-throughput

0.606

High

725096

TEKT4
Tektin-4

2

4

High-throughput

0.606

High

725100

DVL3
Segment polarity protein dishevelled homolog DVL-3

2

5

High-throughput

0.606

High

725104

TRIB3
Tribbles homolog 3

2

4

High-throughput

0.606

High

725105

PFD5
Prefoldin subunit 5

2

2

High-throughput

0.606

High

725110

PRD14
PR domain zinc finger protein 14

2

11

High-throughput

0.606

High

725111

GO45
Golgin-45

2

1

High-throughput

0.606

High

725114

CFA68
Cilia- and flagella-associated protein 68

2

1

High-throughput

0.606

High

725115

PRDM6
Putative histone-lysine N-methyltransferase PRDM6

2

12

High-throughput

0.606

High

725116

AIRIM
AFG2-interacting ribosome maturation factor

2

2

High-throughput

0.606

High

725117

WWOX
WW domain-containing oxidoreductase

2

1

High-throughput

0.606

High

725122

ZRAN1
Ubiquitin thioesterase ZRANB1

2

4

High-throughput

0.606

High

725123

IKZF3
Zinc finger protein Aiolos

2

7

High-throughput

0.606

High

725056

ECM1
Extracellular matrix protein 1

2

0

High-throughput

0.580

High

725121

ZMAT5
Zinc finger matrin-type protein 5

2

0

High-throughput

0.580

High

219842

SMAD6
Mothers against decapentaplegic homolog 6

1

12

Small-scale

0.573

High

725055

SMAD1
Mothers against decapentaplegic homolog 1

1

12

Small-scale

0.573

High

725101

RBPMS
RNA-binding protein with multiple splicing

1

3

High-throughput

0.560

High

65017

GG6L9
Golgin subfamily A member 6-like protein 9

2

6

High-throughput

0.553

High

70130

CRTP1
Cysteine-rich tail protein 1

2

5

High-throughput

0.553

High

300308

KRT34
Keratin, type I cuticular Ha4

2

20

High-throughput

0.553

High

300551

KRT36
Keratin, type I cuticular Ha6

2

20

High-throughput

0.553

High

568612

GYS1
Glycogen [starch] synthase, muscle

2

2

High-throughput

0.553

High

725032

KR121
Keratin-associated protein 12-1

2

7

High-throughput

0.553

High

725033

KR107
Keratin-associated protein 10-7

2

20

High-throughput

0.553

High

725034

KR108
Keratin-associated protein 10-8

2

20

High-throughput

0.553

High

725035

KR109
Keratin-associated protein 10-9

2

20

High-throughput

0.553

High

725044

KRA11
Keratin-associated protein 1-1

2

20

High-throughput

0.553

High

725048

TRAF1
TNF receptor-associated factor 1

2

9

High-throughput

0.553

High

725059

KRA61
Keratin-associated protein 6-1

2

3

High-throughput

0.553

High

725060

KRA62
Keratin-associated protein 6-2

2

3

High-throughput

0.553

High

725062

KR133
Keratin-associated protein 13-3

2

5

High-throughput

0.553

High

725066

PKHG4
Puratrophin-1

2

2

High-throughput

0.553

High

725068

ARH
Low density lipoprotein receptor adapter protein 1

2

8

High-throughput

0.553

High

725069

KPRP
Keratinocyte proline-rich protein

2

2

High-throughput

0.553

High

725071

TENS2
Tensin-2

2

5

High-throughput

0.553

High

725073

K1C40
Keratin, type I cytoskeletal 40

2

20

High-throughput

0.553

High

725075

NADE
Glutamine-dependent NAD(+) synthetase

2

1

High-throughput

0.553

High

725076

ATL4
ADAMTS-like protein 4

2

3

High-throughput

0.553

High

725078

KCTD9
BTB/POZ domain-containing protein KCTD9

2

8

High-throughput

0.553

High

725084

DZIP3
E3 ubiquitin-protein ligase DZIP3

2

2

High-throughput

0.553

High

725085

KR111
Keratin-associated protein 11-1

2

1

High-throughput

0.553

High

725087

KRA13
Keratin-associated protein 1-3

2

20

High-throughput

0.553

High

725090

TRI42
Tripartite motif-containing protein 42

2

19

High-throughput

0.553

High

725093

CEP70
Centrosomal protein of 70 kDa

2

1

High-throughput

0.553

High

725099

KRT35
Keratin, type I cuticular Ha5

2

20

High-throughput

0.553

High

725108

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

2

4

High-throughput

0.553

High

725118

LR2BP
LRP2-binding protein

2

3

High-throughput

0.553

High

274104

ANR17
Ankyrin repeat domain-containing protein 17

1

20

High-throughput

0.536

High

575116

IDE
Insulin-degrading enzyme

1

1

High-throughput

0.536

High

725024

LONM
Lon protease homolog, mitochondrial

1

1

High-throughput

0.536

High

725106

ACBD6
Acyl-CoA-binding domain-containing protein 6

1

18

High-throughput

0.536

High

725102

ARK2N
Protein ARK2N

1

0

High-throughput

0.513

High

725038

BTG2
Protein BTG2

1

2

Small-scale

0.501

High

725081

ZER1
Protein zer-1 homolog

1

1

High-throughput

0.489

High

725089

ANKH1
Ankyrin repeat and KH domain-containing protein 1

1

20

High-throughput

0.489

High

725112

MMAD
Cobalamin trafficking protein CblD

1

1

High-throughput

0.489

High

725046

PPARA
Peroxisome proliferator-activated receptor alpha

1

20

High-throughput

0.481

High

725091

ZNF34
Zinc finger protein 34

1

3

High-throughput

0.481

High

725097

TSC1
Hamartin

1

4

High-throughput

0.481

High

725098

ANS1A
Ankyrin repeat and SAM domain-containing protein 1A

1

20

High-throughput

0.481

High

362179

ABL1
Tyrosine-protein kinase ABL1

1

10

High-throughput

0.479

High

440401

FYN
Tyrosine-protein kinase Fyn

1

10

High-throughput

0.479

High

557127

SRC
Proto-oncogene tyrosine-protein kinase Src

1

10

High-throughput

0.479

High

593925

NCK1
SH2/SH3 adapter protein NCK1

1

14

High-throughput

0.479

High

725036

GRB2
Growth factor receptor-bound protein 2

1

11

High-throughput

0.479

High

725040

IRF8
Interferon regulatory factor 8

1

6

Small-scale

0.479

High

725041

KMT2A
Histone-lysine N-methyltransferase 2A

1

11

Small-scale

0.479

High

725042

TLE3
Transducin-like enhancer protein 3

1

20

High-throughput

0.479

High

725050

SMAD4
Mothers against decapentaplegic homolog 4

1

12

Small-scale

0.479

High

60231

A2RRN7
CADPS protein

1

3

High-throughput

0.470

High

516972

NT2NC
Notch homolog 2 N-terminal-like protein C

1

15

High-throughput

0.470

High

725061

KRA63
Keratin-associated protein 6-3

1

5

High-throughput

0.470

High

725064

Q49AR9
ANKS1A protein

1

8

High-throughput

0.470

High

725083

Q86WV8
TSC complex subunit 1

1

2

High-throughput

0.470

High

725088

Q8IV28
Nidogen-2

1

2

High-throughput

0.470

High

344103

PTBP3
Polypyrimidine tract-binding protein 3

1

2

High-throughput

0.445

High

626089

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

20

High-throughput

0.445

High

487

NBPFJ
NBPF family member NBPF19

1

5

High-throughput

0.439

High

725051

NID2
Nidogen-2

1

2

High-throughput

0.439

High

725053

K1H1
Keratin, type I cuticular Ha1

1

20

High-throughput

0.439

High

725063

MGT5B
Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B

1

1

High-throughput

0.439

High

725080

NT2NA
Notch homolog 2 N-terminal-like protein A

1

15

High-throughput

0.439

High

725124

CAPS1
Calcium-dependent secretion activator 1

1

3

High-throughput

0.439

High

725052

SNX17
Sorting nexin-17

3

0

High-throughput

0.346

High

66138

MET15
12S rRNA N(4)-cytidine methyltransferase METTL15

2

0

High-throughput

0.316

High

437456

CRBA1
Beta-crystallin A3 [Cleaved into: Beta-crystallin A3, isoform A1, Delta4 form; Beta-crystallin A3, isoform A1, Delta7 form; Beta-crystallin A3, isoform A1, Delta8 form]

2

0

High-throughput

0.316

High

725027

FNTB
Protein farnesyltransferase subunit beta

2

0

High-throughput

0.316

High

725057

OBF1
POU domain class 2-associating factor 1

2

0

High-throughput

0.316

High

725058

KR192
Keratin-associated protein 19-2

2

0

High-throughput

0.316

High

725067

ACTMP
Actin maturation protease

2

0

High-throughput

0.316

High

725077

UBP54
Ubiquitin carboxyl-terminal hydrolase 54

2

0

High-throughput

0.316

High

725086

KRA81
Keratin-associated protein 8-1

2

0

High-throughput

0.316

High

725092

SLAI1
SLAIN motif-containing protein 1

2

0

High-throughput

0.316

High

725107

CCM2
Cerebral cavernous malformations 2 protein

2

0

High-throughput

0.316

High

725113

GSTO2
Glutathione S-transferase omega-2

2

0

High-throughput

0.316

High

725072

2ABD
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform

1

0

High-throughput

0.279

Low

725079

MIGA2
Mitoguardin 2

1

0

High-throughput

0.279

Low

725065

KHDC1
KH homology domain-containing protein 1

1

0

High-throughput

0.251

Low


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Last updated: 11Aug2025