HitPredict

Interactor 1: CBX4 (O00257)
E3 SUMO-protein ligase CBX4 (EC 2.3.2.-) (Chromobox protein homolog 4) (Polycomb 2 homolog) (Pc2) (hPc2)
Gene: CBX4

Interactor 2: CBP (Q92793)
CREB-binding protein (Histone lysine acetyltransferase CREBBP) (EC 2.3.1.48) (Protein lactyltransferas CREBBP) (EC 2.3.1.-) (Protein-lysine acetyltransferase CREBBP) (EC 2.3.1.-)
Gene: CREBBP

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.481

Property	Details
Experiments	28680062
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0003682 - chromatin binding GO:0003714 - transcription corepressor activity GO:0005634 - nucleus GO:0005654 - nucleoplasm and 1 others more... GO:0016604 - nuclear body
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 560 Hs			1 2442
+	Hs
		998641 CBX3_HUMAN (9-163): 8.8e-44: 155: 21.94		EP300_HUMAN (1-2426): 0: 874: 55.06
+	Hs
		123181 CBX4_HUMAN (1-560): 7.58e-163: 477: 100.00		BRD2_HUMAN (1065-1195): 9.64e-34: 143: 30.53
+	Hs
		123251 CBX4_HUMAN (1-560): 7.58e-163: 477: 100.00		BRD3_HUMAN (1073-1195): 1.36e-33: 143: 30.89
+	Hs
		123332 CBX4_HUMAN (1-560): 7.58e-163: 477: 100.00		CHD7_HUMAN (70-467): 2.16e-11: 72.1: 9.68
+	Hs
		1262805 MPP8_HUMAN (6-431): 5.25e-87: 289: 13.72		PHIP_HUMAN (1045-1205): 3.22e-45: 183: 30.36
+	Hs
		316175 CBX6_HUMAN (1-419): 4.68e-61: 209: 24.19		BRWD1_HUMAN (1053-1204): 5.63e-38: 159: 26.83
+	Hs
		1027151 CBX3_HUMAN (9-163): 8.8e-44: 155: 21.94		PHIP_HUMAN (1045-1205): 3.22e-45: 183: 30.36
+	Hs
		1067203 CDYL_HUMAN (2-288): 4.47e-50: 183: 16.35		BRD3_HUMAN (1073-1195): 1.36e-33: 143: 30.89
+	Mm
		1266178 Q9DCC5_MOUSE (9-163): 8.8e-44: 155: 21.94		TRI66_MOUSE (334-1233): 8.35e-38: 158: 13.97
+	Hs
		1027331 CBX3_HUMAN (9-163): 8.8e-44: 155: 21.94		TRI33_HUMAN (694-1207): 3.25e-37: 156: 14.83
+	Mm
		1143042 CBX5_MOUSE (11-169): 3.2e-41: 149: 20.71		TRI66_MOUSE (334-1233): 8.35e-38: 158: 13.97
+	Mm
		1145016 Q9DCC5_MOUSE (9-163): 8.8e-44: 155: 21.94		TIF1A_MOUSE (681-1214): 3.81e-36: 152: 16.14
+	Hs
		170353 CBX3_HUMAN (9-163): 8.8e-44: 155: 21.94		TIF1A_HUMAN (667-1202): 2.17e-34: 147: 17.97
+	Mm
		1143020 CBX5_MOUSE (11-169): 3.2e-41: 149: 20.71		TIF1A_MOUSE (681-1214): 3.81e-36: 152: 16.14
+	Hs
		1027010 CBX3_HUMAN (9-163): 8.8e-44: 155: 21.94		BRD3_HUMAN (1073-1195): 1.36e-33: 143: 30.89
+	Hs
		631418 CBX3_HUMAN (9-163): 8.8e-44: 155: 21.94		BRD2_HUMAN (1065-1195): 9.64e-34: 143: 30.53
+	Hs
		170295 CBX5_HUMAN (11-171): 7.04e-41: 148: 19.88		TIF1A_HUMAN (667-1202): 2.17e-34: 147: 17.97
+	Hs
		631371 CBX5_HUMAN (11-171): 7.04e-41: 148: 19.88		BRD2_HUMAN (1065-1195): 9.64e-34: 143: 30.53
+	Hs
		316024 CBX6_HUMAN (1-419): 4.68e-61: 209: 24.19		BPTF_HUMAN (1831-2314): 7.5e-12: 73.6: 11.09
+	Hs
		1027300 CBX3_HUMAN (9-163): 8.8e-44: 155: 21.94		CHD7_HUMAN (70-467): 2.16e-11: 72.1: 9.68