Protein: GSDME
Gasdermin-E (Inversely correlated with estrogen receptor expression 1) (ICERE-1) (Non-syndromic hearing impairment protein 5) [Cleaved into: Gasdermin-E, N-terminal (GSDME-NT); Gasdermin-E, C-terminal (GSDME-CT)]

Gene: GSDME
Organism: Homo sapiens
Interactions: 174
UniProt ID: O60443

Gene Ontology (top 5):
GO:0002839 - positive regulation of immune response to tumor cell
GO:0005546 - phosphatidylinositol-4,5-bisphosphate binding
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

248812

SCN2B
Sodium channel regulatory subunit beta-2

4

1

High-throughput

0.892

High

248893

BTNL9
Butyrophilin-like protein 9

1

2

High-throughput

0.691

High

248836

EPHA1
Ephrin type-A receptor 1

3

1

High-throughput

0.662

High

248913

SIGL1
SIGLEC family-like protein 1

3

0

High-throughput

0.634

High

171367

S27A2
Long-chain fatty acid transport protein 2

2

1

High-throughput

0.628

High

248877

PLEC
Plectin

2

1

High-throughput

0.628

High

248900

GPAT4
Glycerol-3-phosphate acyltransferase 4

2

2

High-throughput

0.628

High

248924

MUL1
Mitochondrial ubiquitin ligase activator of NFKB 1

2

0

High-throughput

0.602

High

248926

TIFA
TRAF-interacting protein with FHA domain-containing protein A

2

0

High-throughput

0.580

High

71184

HIDE1
Protein HIDE1

2

0

High-throughput

0.576

High

248827

GLPA
Glycophorin-A

2

0

High-throughput

0.576

High

248841

CD70
CD70 antigen

2

0

High-throughput

0.576

High

248955

OCAD1
OCIA domain-containing protein 1

2

0

High-throughput

0.576

High

248858

GSDMD
Gasdermin-D

1

1

High-throughput

0.575

High

248831

CFTR
Cystic fibrosis transmembrane conductance regulator

1

3

High-throughput

0.541

High

248929

CEP63
Centrosomal protein of 63 kDa

1

1

High-throughput

0.536

High

161552

ITBP1
Integrin beta-1-binding protein 1

1

0

High-throughput

0.518

High

248834

PTN
Pleiotrophin

1

0

High-throughput

0.518

High

248830

TACD2
Tumor-associated calcium signal transducer 2

1

0

High-throughput

0.513

High

248837

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.513

High

248863

EFNB1
Ephrin-B1

1

0

High-throughput

0.513

High

248891

KLC3
Kinesin light chain 3

1

0

High-throughput

0.513

High

248903

CMTD1
Catechol O-methyltransferase domain-containing protein 1

1

0

High-throughput

0.513

High

248917

F174A
Membrane protein FAM174A

1

0

High-throughput

0.513

High

248927

HVCN1
Voltage-gated hydrogen channel 1

1

0

High-throughput

0.513

High

248928

RUSF1
RUS family member 1

1

0

High-throughput

0.513

High

248930

CDC5L
Cell division cycle 5-like protein

1

0

High-throughput

0.513

High

248966

GPR45
Probable G-protein coupled receptor 45

1

0

High-throughput

0.513

High

248904

VSIG1
V-set and immunoglobulin domain-containing protein 1

1

0

High-throughput

0.481

High

248835

FLNA
Filamin-A

1

1

Small-scale

0.479

High

248864

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

2

Small-scale

0.479

High

248871

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

2

Small-scale

0.479

High

248895

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.479

High

248901

UBP48
Ubiquitin carboxyl-terminal hydrolase 48

1

1

Small-scale

0.479

High

162401

ANM5
Protein arginine N-methyltransferase 5

1

0

Small-scale

0.458

High

248826

EGFR
Epidermal growth factor receptor

1

0

High-throughput

0.458

High

248828

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.458

High

248843

MYH9
Myosin-9

1

0

Small-scale

0.458

High

248851

FAS
Fatty acid synthase

1

0

Small-scale

0.458

High

248852

KIF11
Kinesin-like protein KIF11

1

0

Small-scale

0.458

High

248859

ACTG
Actin, cytoplasmic 2

1

0

Small-scale

0.458

High

248865

OTUD4
OTU domain-containing protein 4

1

0

Small-scale

0.458

High

248873

MVP
Major vault protein

1

0

Small-scale

0.458

High

248876

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.458

High

248921

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

0

High-throughput

0.458

High

248948

BIRC6
Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6

1

0

High-throughput

0.458

High

123016

DX39A
ATP-dependent RNA helicase DDX39A

1

1

High-throughput

0.445

High

123298

BACH
Cytosolic acyl coenzyme A thioester hydrolase

1

1

High-throughput

0.445

High

228054

PM34
Peroxisomal membrane protein PMP34

1

2

High-throughput

0.445

High

248811

SNX2
Sorting nexin-2

1

1

High-throughput

0.445

High

248814

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.445

High

248817

GLSK
Glutaminase kidney isoform, mitochondrial

1

1

High-throughput

0.445

High

248842

ERD22
ER lumen protein-retaining receptor 2

1

1

High-throughput

0.445

High

248846

MLH1
DNA mismatch repair protein Mlh1

1

1

High-throughput

0.445

High

248853

SMTN
Smoothelin

1

2

High-throughput

0.445

High

248855

S12A2
Solute carrier family 12 member 2

1

1

High-throughput

0.445

High

248890

S27A4
Long-chain fatty acid transport protein 4

1

1

High-throughput

0.445

High

248892

LCLT1
Lysocardiolipin acyltransferase 1

1

1

High-throughput

0.445

High

248906

LRC8A
Volume-regulated anion channel subunit LRRC8A

1

1

High-throughput

0.445

High

248914

DHB11
Estradiol 17-beta-dehydrogenase 11

1

2

High-throughput

0.445

High

248938

S12A9
Solute carrier family 12 member 9

1

1

High-throughput

0.445

High

248957

MTCH1
Mitochondrial carrier homolog 1

1

2

High-throughput

0.445

High

248962

DHRS7
Dehydrogenase/reductase SDR family member 7

1

2

High-throughput

0.445

High

248964

SRPRB
Signal recognition particle receptor subunit beta

1

1

High-throughput

0.445

High

248965

SNX8
Sorting nexin-8

1

1

High-throughput

0.445

High

166821

MGST3
Glutathione S-transferase 3, mitochondrial

1

0

High-throughput

0.426

High

183111

GNPAT
Dihydroxyacetone phosphate acyltransferase

1

0

High-throughput

0.426

High

190581

MRP4
ATP-binding cassette sub-family C member 4

1

0

High-throughput

0.426

High

248809

UGDH
UDP-glucose 6-dehydrogenase

1

0

High-throughput

0.426

High

248813

NU155
Nuclear pore complex protein Nup155

1

0

High-throughput

0.426

High

248815

CLPX
ATP-dependent clpX-like chaperone, mitochondrial

1

0

High-throughput

0.426

High

248816

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.426

High

248818

MFN2
Mitofusin-2

1

0

High-throughput

0.426

High

248820

GNAS3
Neuroendocrine secretory protein 55

1

0

High-throughput

0.426

High

248822

CLPT1
Putative lipid scramblase CLPTM1

1

0

High-throughput

0.426

High

248823

TOM40
Mitochondrial import receptor subunit TOM40 homolog

1

0

High-throughput

0.426

High

248824

PX11B
Peroxisomal membrane protein 11B

1

0

High-throughput

0.426

High

248825

DYR
Dihydrofolate reductase

1

0

High-throughput

0.426

High

248833

RAB3B
Ras-related protein Rab-3B

1

0

High-throughput

0.426

High

248839

TNR5
Tumor necrosis factor receptor superfamily member 5

1

0

High-throughput

0.426

High

248840

AL4A1
Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial

1

0

High-throughput

0.426

High

248844

SOAT1
Sterol O-acyltransferase 1

1

0

High-throughput

0.426

High

248845

FDFT
Squalene synthase

1

0

High-throughput

0.426

High

248847

MTOR
Serine/threonine-protein kinase mTOR

1

0

High-throughput

0.426

High

248848

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

0

High-throughput

0.426

High

248849

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

0

High-throughput

0.426

High

248856

PEX3
Peroxisomal biogenesis factor 3

1

0

High-throughput

0.426

High

248866

STX5
Syntaxin-5

1

0

High-throughput

0.426

High

248867

SKP2
S-phase kinase-associated protein 2

1

0

High-throughput

0.426

High

248868

NNTM
NAD(P) transhydrogenase, mitochondrial

1

0

High-throughput

0.426

High

248870

RAB32
Ras-related protein Rab-32

1

0

High-throughput

0.426

High

248872

ERG1
Squalene monooxygenase

1

0

High-throughput

0.426

High

248874

RB3GP
Rab3 GTPase-activating protein catalytic subunit

1

0

High-throughput

0.426

High

248875

LRC14
Leucine-rich repeat-containing protein 14

1

0

High-throughput

0.426

High

248878

L2GL1
Lethal(2) giant larvae protein homolog 1

1

0

High-throughput

0.426

High

248879

MARE2
Microtubule-associated protein RP/EB family member 2

1

0

High-throughput

0.426

High

248881

MSMO1
Methylsterol monooxygenase 1

1

0

High-throughput

0.426

High

248882

PDS5A
Sister chromatid cohesion protein PDS5 homolog A

1

0

High-throughput

0.426

High

248883

ERC6L
DNA excision repair protein ERCC-6-like

1

0

High-throughput

0.426

High

248884

QRIC1
Transcriptional regulator QRICH1

1

0

High-throughput

0.426

High

248885

PAR14
Protein mono-ADP-ribosyltransferase PARP14

1

0

High-throughput

0.426

High

248886

HIKES
Protein Hikeshi

1

0

High-throughput

0.426

High

248887

RIF1
Telomere-associated protein RIF1

1

0

High-throughput

0.426

High

248888

SCMC1
Mitochondrial adenyl nucleotide antiporter SLC25A24

1

0

High-throughput

0.426

High

248896

TMTC3
Protein O-mannosyl-transferase TMTC3

1

0

High-throughput

0.426

High

248897

UN13D
Protein unc-13 homolog D

1

0

High-throughput

0.426

High

248899

GALT7
N-acetylgalactosaminyltransferase 7

1

0

High-throughput

0.426

High

248902

AACS
Acetoacetyl-CoA synthetase

1

0

High-throughput

0.426

High

248905

TPPC5
Trafficking protein particle complex subunit 5

1

0

High-throughput

0.426

High

248908

RPTOR
Regulatory-associated protein of mTOR

1

0

High-throughput

0.426

High

248910

ABD12
Lysophosphatidylserine lipase ABHD12

1

0

High-throughput

0.426

High

248911

CISD2
CDGSH iron-sulfur domain-containing protein 2

1

0

High-throughput

0.426

High

248915

DGLB
Diacylglycerol lipase-beta

1

0

High-throughput

0.426

High

248916

FBX22
F-box only protein 22

1

0

High-throughput

0.426

High

248920

DCAKD
Dephospho-CoA kinase domain-containing protein

1

0

High-throughput

0.426

High

248922

SYMPK
Symplekin

1

0

High-throughput

0.426

High

248931

PLIN2
Perilipin-2

1

0

High-throughput

0.426

High

248932

CND3
Condensin complex subunit 3

1

0

High-throughput

0.426

High

248935

NDC1
Nucleoporin NDC1

1

0

High-throughput

0.426

High

248940

UCK2
Uridine-cytidine kinase 2

1

0

High-throughput

0.426

High

248941

EHD4
EH domain-containing protein 4

1

0

High-throughput

0.426

High

248943

RBGPR
Rab3 GTPase-activating protein non-catalytic subunit

1

0

High-throughput

0.426

High

248944

UN45A
Protein unc-45 homolog A

1

0

High-throughput

0.426

High

248947

RIC8A
Chaperone Ric-8A

1

0

High-throughput

0.426

High

248949

SAR1A
Small COPII coat GTPase SAR1A

1

0

High-throughput

0.426

High

248950

AAAS
Aladin

1

0

High-throughput

0.426

High

248951

LRC4B
Leucine-rich repeat-containing protein 4B

1

0

High-throughput

0.426

High

248953

ABCF3
ATP-binding cassette sub-family F member 3

1

0

High-throughput

0.426

High

248958

IPO11
Importin-11

1

0

High-throughput

0.426

High

248959

XPO7
Exportin-7

1

0

High-throughput

0.426

High

248963

FBX7
F-box only protein 7

1

0

High-throughput

0.426

High

248967

ALG5
Dolichyl-phosphate beta-glucosyltransferase

1

0

High-throughput

0.426

High

248838

ERD21
ER lumen protein-retaining receptor 1

1

1

High-throughput

0.407

High

248854

PMS1
PMS1 protein homolog 1

1

1

High-throughput

0.407

High

248857

DHB7
3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7

1

1

High-throughput

0.407

High

248860

SC11A
Signal peptidase complex catalytic subunit SEC11A

1

1

High-throughput

0.407

High

248919

SFXN5
Sideroflexin-5

1

1

High-throughput

0.407

High

248925

FAKD4
FAST kinase domain-containing protein 4

1

2

High-throughput

0.407

High

248939

SC11C
Signal peptidase complex catalytic subunit SEC11C

1

1

High-throughput

0.407

High

248942

S2532
Solute carrier family 25 member 32

1

2

High-throughput

0.407

High

248956

FAKD2
FAST kinase domain-containing protein 2, mitochondrial

1

2

High-throughput

0.407

High

248960

ACOT9
Acyl-coenzyme A thioesterase 9, mitochondrial

1

1

High-throughput

0.407

High

248907

ZSC29
Zinc finger and SCAN domain-containing protein 29

2

0

High-throughput

0.328

High

248946

MRS2
Magnesium transporter MRS2 homolog, mitochondrial

2

0

High-throughput

0.328

High

248810

TPST2
Protein-tyrosine sulfotransferase 2

1

0

High-throughput

0.279

Low

248829

QCR6
Cytochrome b-c1 complex subunit 6, mitochondrial

1

0

High-throughput

0.279

Low

248869

SNW1
SNW domain-containing protein 1

1

0

High-throughput

0.279

Low

248898

B3GN8
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8

1

0

High-throughput

0.279

Low

135758

RTCA
RNA 3'-terminal phosphate cyclase

1

0

High-throughput

0.232

Low

177492

MRPP3
Mitochondrial ribonuclease P catalytic subunit

1

0

High-throughput

0.232

Low

184953

SPTC2
Serine palmitoyltransferase 2

1

0

High-throughput

0.232

Low

223772

NDUA2
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2

1

0

High-throughput

0.232

Low

229381

IDH3B
Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial

1

0

High-throughput

0.232

Low

248819

LETM1
Mitochondrial proton/calcium exchanger protein

1

0

High-throughput

0.232

Low

248821

MPC2
Mitochondrial pyruvate carrier 2

1

0

High-throughput

0.232

Low

248832

ETFA
Electron transfer flavoprotein subunit alpha, mitochondrial

1

0

High-throughput

0.232

Low

248850

EFTS
Elongation factor Ts, mitochondrial

1

0

High-throughput

0.232

Low

248861

ATL3
ADAMTS-like protein 3

1

0

High-throughput

0.232

Low

248862

COG7
Conserved oligomeric Golgi complex subunit 7

1

0

High-throughput

0.232

Low

248880

NSDHL
Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating

1

0

High-throughput

0.232

Low

248889

TTI2
TELO2-interacting protein 2

1

0

High-throughput

0.232

Low

248894

HACD2
Very-long-chain

1

0

High-throughput

0.232

Low

248909

ARM10
Armadillo repeat-containing protein 10

1

0

High-throughput

0.232

Low

248912

FITM2
Acyl-coenzyme A diphosphatase FITM2

1

0

High-throughput

0.232

Low

248918

RDH11
Retinol dehydrogenase 11

1

0

High-throughput

0.232

Low

248923

SCAM4
Secretory carrier-associated membrane protein 4

1

0

High-throughput

0.232

Low

248933

CYBC1
Cytochrome b-245 chaperone 1

1

0

High-throughput

0.232

Low

248934

TIM29
Mitochondrial import inner membrane translocase subunit Tim29

1

0

High-throughput

0.232

Low

248936

TMM70
Transmembrane protein 70, mitochondrial

1

0

High-throughput

0.232

Low

248937

ALG8
Dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase

1

0

High-throughput

0.232

Low

248945

ARMT1
Damage-control phosphatase ARMT1

1

0

High-throughput

0.232

Low

248952

SAC1
Phosphatidylinositol-3-phosphatase SAC1

1

0

High-throughput

0.232

Low

248954

HPF1
Histone PARylation factor 1

1

0

High-throughput

0.232

Low

248961

TMX2
Thioredoxin-related transmembrane protein 2

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025