Protein: ACOT9
Acyl-coenzyme A thioesterase 9, mitochondrial (Acyl-CoA thioesterase 9) (EC 3.1.2.-) (EC 3.1.2.2) (Acyl-CoA thioester hydrolase 9)

Gene: ACOT9
Organism: Homo sapiens
Interactions: 150
UniProt ID: Q9Y305

Gene Ontology (top 5):
GO:0001676 - long-chain fatty acid metabolic process
GO:0003986 - acetyl-CoA hydrolase activity
GO:0005739 - mitochondrion
GO:0005743 - mitochondrial inner membrane
GO:0005759 - mitochondrial matrix

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1453785

KCMF1
E3 ubiquitin-protein ligase KCMF1

3

1

Small-scale

0.593

High

243355

PRKN
E3 ubiquitin-protein ligase parkin

2

2

High-throughput

0.584

High

927181

ATX3
Ataxin-3

2

1

Small-scale

0.584

High

366270

FA9
Coagulation factor IX

2

5

High-throughput

0.574

High

1462678

PSG8
Pregnancy-specific beta-1-glycoprotein 8

2

1

High-throughput

0.574

High

711439

SHC1
SHC-transforming protein 1

2

1

High-throughput

0.571

High

1139878

SETB1
Histone-lysine N-methyltransferase SETDB1

2

2

High-throughput

0.558

High

530632

TAU
Microtubule-associated protein tau

1

1

High-throughput

0.536

High

364067

EGFR
Epidermal growth factor receptor

2

1

High-throughput

0.533

High

473200

RU17
U1 small nuclear ribonucleoprotein 70 kDa

2

1

High-throughput

0.533

High

988847

RAC1
Ras-related C3 botulinum toxin substrate 1

2

4

High-throughput

0.521

High

275420

NDUS7
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

1

0

High-throughput

0.513

High

788275

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

0

High-throughput

0.513

High

1123487

ICT1
Large ribosomal subunit protein mL62

1

0

High-throughput

0.513

High

1310546

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

564592

CFTR
Cystic fibrosis transmembrane conductance regulator

2

1

High-throughput

0.504

High

647685

UBA1
Ubiquitin-like modifier-activating enzyme 1

1

0

High-throughput

0.493

High

628921

TRYB2
Tryptase beta-2

1

3

High-throughput

0.489

High

640338

EPHA1
Ephrin type-A receptor 1

1

1

High-throughput

0.489

High

653747

PROZ
Vitamin K-dependent protein Z

1

4

High-throughput

0.489

High

1366147

DYRK2
Dual specificity tyrosine-phosphorylation-regulated kinase 2

1

2

High-throughput

0.489

High

1434623

ZBTB3
Zinc finger and BTB domain-containing protein 3

1

2

High-throughput

0.489

High

1446167

CABP2
Calcium-binding protein 2

1

1

High-throughput

0.489

High

487905

PARP1
Poly [ADP-ribose] polymerase 1

1

2

High-throughput

0.479

High

533091

CH60
60 kDa heat shock protein, mitochondrial

1

1

High-throughput

0.479

High

1033825

PO5F1
POU domain, class 5, transcription factor 1

1

2

High-throughput

0.479

High

1087629

GRSF1
G-rich sequence factor 1

1

1

Small-scale

0.479

High

1108304

SQSTM
Sequestosome-1

1

1

High-throughput

0.479

High

191172

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

0

High-throughput

0.458

High

279982

CISY
Citrate synthase, mitochondrial

1

0

High-throughput

0.458

High

471338

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

0

High-throughput

0.458

High

519274

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

0

High-throughput

0.458

High

829018

MDHM
Malate dehydrogenase, mitochondrial

1

0

High-throughput

0.458

High

1036012

KIF23
Kinesin-like protein KIF23

1

0

High-throughput

0.458

High

1090601

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

0

High-throughput

0.458

High

1142711

PDK1
[Pyruvate dehydrogenase

1

0

High-throughput

0.458

High

1162631

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

0

High-throughput

0.458

High

1203466

OXLD1
Oxidoreductase-like domain-containing protein 1

1

0

High-throughput

0.458

High

1207190

SYAM
Alanine--tRNA ligase, mitochondrial

1

0

High-throughput

0.458

High

1216504

MIC10
MICOS complex subunit MIC10

1

0

Small-scale

0.458

High

1234577

MRM1
rRNA methyltransferase 1, mitochondrial

1

0

High-throughput

0.458

High

1324201

PLD6
Mitochondrial cardiolipin hydrolase

1

0

High-throughput

0.458

High

1367649

ESR2
Estrogen receptor beta

1

0

High-throughput

0.458

High

1381783

FAKD4
FAST kinase domain-containing protein 4

1

0

High-throughput

0.458

High

1415718

TR61B
tRNA

1

0

High-throughput

0.458

High

1209817

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

2

High-throughput

0.445

High

272567

OBSL1
Obscurin-like protein 1

1

2

High-throughput

0.437

High

353638

AGR2
Anterior gradient protein 2 homolog

1

1

High-throughput

0.437

High

376126

RASK
GTPase KRas

1

1

High-throughput

0.437

High

590089

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.437

High

615609

NELFE
Negative elongation factor E

1

1

High-throughput

0.437

High

650499

FGFR3
Fibroblast growth factor receptor 3

1

3

High-throughput

0.437

High

696928

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.437

High

769574

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

777800

VGFR3
Vascular endothelial growth factor receptor 3

1

1

High-throughput

0.437

High

800183

COIL
Coilin

1

1

High-throughput

0.437

High

879644

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

1

High-throughput

0.437

High

884424

UBE2A
Ubiquitin-conjugating enzyme E2 A

1

1

Small-scale

0.437

High

962655

RHOA
Transforming protein RhoA

1

5

High-throughput

0.437

High

971328

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

3

High-throughput

0.437

High

978420

RHOB
Rho-related GTP-binding protein RhoB

1

5

High-throughput

0.437

High

984341

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

1

High-throughput

0.437

High

991001

UBE2B
Ubiquitin-conjugating enzyme E2 B

1

1

Small-scale

0.437

High

1015928

RHOG
Rho-related GTP-binding protein RhoG

1

4

High-throughput

0.437

High

1114710

CUL3
Cullin-3

1

1

High-throughput

0.437

High

1138789

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

1

High-throughput

0.437

High

1228500

FTM
Protein fantom

1

1

High-throughput

0.437

High

1253759

RHG36
Rho GTPase-activating protein 36

1

1

High-throughput

0.437

High

1256195

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

1256819

NYAP1
Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1

1

3

Small-scale

0.437

High

1277006

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.437

High

1286962

TM11B
Transmembrane protease serine 11B

1

3

High-throughput

0.437

High

1326394

NIN
Ninein

1

1

High-throughput

0.437

High

1330286

KI3L3
Killer cell immunoglobulin-like receptor 3DL3

1

1

High-throughput

0.437

High

1399129

SCLT1
Sodium channel and clathrin linker 1

1

1

High-throughput

0.437

High

1434292

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.437

High

1437247

NANOG
Homeobox protein NANOG

1

1

High-throughput

0.437

High

1447475

ANLN
Anillin

1

1

High-throughput

0.437

High

1448858

TMPS4
Transmembrane protease serine 4

1

3

High-throughput

0.437

High

1454241

NYAP2
Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2

1

3

Small-scale

0.437

High

1458559

HDAC6
Protein deacetylase HDAC6

1

2

High-throughput

0.437

High

1459394

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.437

High

1460439

DS13B
Dual specificity protein phosphatase 13B

1

2

High-throughput

0.437

High

1167

SIM26
Small integral membrane protein 26

1

0

High-throughput

0.426

High

1449847

ABHDA
Palmitoyl-protein thioesterase ABHD10, mitochondrial

1

0

High-throughput

0.426

High

1491019

SIR4
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial

1

0

High-throughput

0.426

High

47610

A0A8I5QEB2
Killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 3

1

1

High-throughput

0.407

High

248960

GSDME
Gasdermin-E

1

1

High-throughput

0.407

High

437838

HEPS
Serine protease hepsin

1

2

High-throughput

0.407

High

1314074

YAF2
YY1-associated factor 2

1

1

High-throughput

0.407

High

1326165

RYBP
RING1 and YY1-binding protein

1

1

High-throughput

0.407

High

1366320

LPAR1
Lysophosphatidic acid receptor 1

1

1

High-throughput

0.407

High

154912

ISLR
Immunoglobulin superfamily containing leucine-rich repeat protein

3

0

High-throughput

0.347

High

921585

PGTB2
Geranylgeranyl transferase type-2 subunit beta

3

0

High-throughput

0.347

High

193646

PDPK1
3-phosphoinositide-dependent protein kinase 1

3

0

High-throughput

0.330

High

317485

GFPT2
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2

2

0

High-throughput

0.328

High

566907

CO6
Complement component C6

2

0

High-throughput

0.328

High

1315509

DAAF8
Dynein axonemal assembly factor 8

2

0

High-throughput

0.328

High

1316078

TRM2A
tRNA

2

0

High-throughput

0.328

High

1462785

LAMP3
Lysosome-associated membrane glycoprotein 3

2

0

High-throughput

0.328

High

1389320

T3HPD
Trans-3-hydroxy-L-proline dehydratase

2

0

High-throughput

0.318

High

475785

K2C7
Keratin, type II cytoskeletal 7

1

0

High-throughput

0.279

Low

683766

PTX3
Pentraxin-related protein PTX3

1

0

High-throughput

0.279

Low

821694

TPOR
Thrombopoietin receptor

1

0

High-throughput

0.279

Low

867539

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.279

Low

1178800

AAK1
AP2-associated protein kinase 1

1

0

High-throughput

0.279

Low

1208248

SPXN4
Sperm protein associated with the nucleus on the X chromosome N4

1

0

High-throughput

0.279

Low

1395168

HIPL1
HHIP-like protein 1

1

0

High-throughput

0.279

Low

1453961

RN181
E3 ubiquitin-protein ligase RNF181

1

0

High-throughput

0.279

Low

1458476

ASH2L
Set1/Ash2 histone methyltransferase complex subunit ASH2

1

0

High-throughput

0.279

Low

1460141

NRBP
Nuclear receptor-binding protein

1

0

High-throughput

0.279

Low

1461665

ISY1
Pre-mRNA-splicing factor ISY1 homolog

1

0

High-throughput

0.279

Low

1491018

PCDGD
Protocadherin gamma-B1

1

0

High-throughput

0.279

Low

1491020

COMDA
COMM domain-containing protein 10

1

0

High-throughput

0.279

Low

1491021

MYO16
Unconventional myosin-XVI

1

0

Small-scale

0.269

Low

508871

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

0

High-throughput

0.261

Low

180114

BET1
BET1 homolog

1

0

High-throughput

0.249

Low

346535

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.249

Low

377791

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

0

High-throughput

0.249

Low

538155

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.249

Low

831684

CCNF
Cyclin-F

1

0

High-throughput

0.249

Low

920387

PLK1
Serine/threonine-protein kinase PLK1

1

0

High-throughput

0.249

Low

965352

WDR5
WD repeat-containing protein 5

1

0

High-throughput

0.249

Low

1022206

DAB2
Disabled homolog 2

1

0

Small-scale

0.249

Low

1143602

PCM1
Pericentriolar material 1 protein

1

0

High-throughput

0.249

Low

1247053

RICTR
Rapamycin-insensitive companion of mTOR

1

0

High-throughput

0.249

Low

1291611

HOOK3
Protein Hook homolog 3

1

0

High-throughput

0.249

Low

1311996

SKA3
Spindle and kinetochore-associated protein 3

1

0

Small-scale

0.249

Low

1339243

NUP35
Nucleoporin NUP35

1

0

High-throughput

0.249

Low

1380694

FBX32
F-box only protein 32

1

0

High-throughput

0.249

Low

1382013

CK052
Uncharacterized protein C11orf52

1

0

High-throughput

0.249

Low

1393848

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.249

Low

1399018

BROMI
Protein broad-minded

1

0

Small-scale

0.249

Low

1428681

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

0

High-throughput

0.249

Low

1429407

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.249

Low

1439422

E41LA
Band 4.1-like protein 4A

1

0

High-throughput

0.249

Low

1446454

BRD7
Bromodomain-containing protein 7

1

0

High-throughput

0.249

Low

1448340

FBX6
F-box only protein 6

1

0

High-throughput

0.249

Low

1453060

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.249

Low

730978

1433S
14-3-3 protein sigma

1

0

High-throughput

0.232

Low

898895

RL14
Large ribosomal subunit protein eL14

1

0

High-throughput

0.232

Low

942970

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

0

High-throughput

0.232

Low

985959

RL11
Large ribosomal subunit protein uL5

1

0

High-throughput

0.232

Low

1007421

S35A1
CMP-sialic acid transporter

1

0

High-throughput

0.232

Low

1063090

S20A2
Sodium-dependent phosphate transporter 2

1

0

High-throughput

0.232

Low

1239347

ARMC6
Armadillo repeat-containing protein 6

1

0

High-throughput

0.232

Low

1411917

UTP23
rRNA-processing protein UTP23 homolog

1

0

High-throughput

0.232

Low

1417174

S12A9
Solute carrier family 12 member 9

1

0

High-throughput

0.232

Low

1431296

DJC25
DnaJ homolog subfamily C member 25

1

0

High-throughput

0.232

Low

1451043

RBM28
RNA-binding protein 28

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025