HitPredict

Interactor 1: SPT5H (O00267)
Transcription elongation factor SPT5 (hSPT5) (DRB sensitivity-inducing factor 160 kDa subunit) (DSIF p160) (DRB sensitivity-inducing factor large subunit) (DSIF large subunit) (Tat-cotransactivator 1 protein) (Tat-CT1 protein)
Gene: SUPT5H

Interactor 2: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	35563538, 21145461
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 1087 Hs			1 768
+	Hs
		867096 SC24C_HUMAN (794-1057): 2.47e-15: 83.4: 14.88		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		302286 SC31A_HUMAN (795-1060): 7.42e-11: 68.8: 12.20		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		1042217 LPP_HUMAN (612-895): 8.64e-10: 64.9: 9.79		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		1042076 KMT2C_HUMAN (634-1078): 3.48e-09: 63.4: 13.80		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		1042196 CBP_HUMAN (747-1035): 5.79e-09: 62.6: 12.81		CUL3_HUMAN (1-768): 0: 951: 100.00