Protein: MYH6
Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha)

Gene: MYH6
Organism: Homo sapiens
Interactions: 68
UniProt ID: P13533

Gene Ontology (top 5):
GO:0000146 - microfilament motor activity
GO:0001701 - in utero embryonic development
GO:0001725 - stress fiber
GO:0002026 - regulation of the force of heart contraction
GO:0002027 - regulation of heart rate

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

535921

MYH3
Myosin-3

1

17

High-throughput

0.691

High

562992

MYH6
Myosin-6

1

17

Small-scale

0.647

High

563014

HIF1A
Hypoxia-inducible factor 1-alpha

2

8

High-throughput

0.628

High

348954

LATS1
Serine/threonine-protein kinase LATS1

1

16

High-throughput

0.536

High

562993

CFTR
Cystic fibrosis transmembrane conductance regulator

1

11

High-throughput

0.536

High

562995

KAPCB
cAMP-dependent protein kinase catalytic subunit beta

1

10

High-throughput

0.536

High

562999

MP2K3
Dual specificity mitogen-activated protein kinase kinase 3

1

20

High-throughput

0.536

High

563028

DOCK6
Dedicator of cytokinesis protein 6

1

1

High-throughput

0.536

High

563030

SORT
Sortilin

1

2

High-throughput

0.536

High

563037

AAKG2
5'-AMP-activated protein kinase subunit gamma-2

1

9

High-throughput

0.536

High

563038

HSPB8
Heat shock protein beta-8

1

10

High-throughput

0.536

High

563039

UBP24
Ubiquitin carboxyl-terminal hydrolase 24

1

7

High-throughput

0.536

High

563041

DCAF1
DDB1- and CUL4-associated factor 1

1

3

High-throughput

0.536

High

158103

COPE
Coatomer subunit epsilon

1

0

High-throughput

0.513

High

245667

GANP
Germinal-center associated nuclear protein

1

0

High-throughput

0.513

High

424343

HMGN1
Non-histone chromosomal protein HMG-14

1

0

High-throughput

0.513

High

539028

UMPS
Uridine 5'-monophosphate synthase

1

0

High-throughput

0.513

High

563004

TYB4
Thymosin beta-4

1

0

High-throughput

0.513

High

563019

FBX31
F-box only protein 31

1

0

High-throughput

0.513

High

563021

SPICE
Spindle and centriole-associated protein 1

1

0

High-throughput

0.513

High

563031

MBB1A
Myb-binding protein 1A

1

0

High-throughput

0.513

High

563013

HSPB2
Heat shock protein beta-2

1

10

High-throughput

0.508

High

395408

ESR1
Estrogen receptor

1

9

Small-scale

0.501

High

563008

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

18

Small-scale

0.501

High

563025

TRI63
E3 ubiquitin-protein ligase TRIM63

1

8

Small-scale

0.501

High

563032

NEUL2
Neuralized-like protein 2

1

1

Small-scale

0.501

High

563036

CACO1
Calcium-binding and coiled-coil domain-containing protein 1

1

19

Small-scale

0.501

High

64421

BDP1
Transcription factor TFIIIB component B'' homolog

1

15

High-throughput

0.489

High

342097

BRD1
Bromodomain-containing protein 1

1

1

High-throughput

0.489

High

563012

TRIPB
Thyroid receptor-interacting protein 11

1

19

High-throughput

0.489

High

563020

SPT2
Protein SPT2 homolog

1

1

High-throughput

0.489

High

563023

LZTR1
Leucine-zipper-like transcriptional regulator 1

1

11

High-throughput

0.489

High

563024

ABTB2
Ankyrin repeat and BTB/POZ domain-containing protein 2

1

9

High-throughput

0.489

High

347501

BAG3
BAG family molecular chaperone regulator 3

1

1

Small-scale

0.479

High

387221

APOA1
Apolipoprotein A-I

1

1

High-throughput

0.479

High

388037

MBP
Myelin basic protein

1

1

High-throughput

0.479

High

562994

CXA1
Gap junction alpha-1 protein

1

2

Small-scale

0.479

High

562998

NSF
Vesicle-fusing ATPase

1

3

High-throughput

0.479

High

563000

MCM2
DNA replication licensing factor MCM2

1

6

High-throughput

0.479

High

563001

BAP31
B-cell receptor-associated protein 31

1

11

High-throughput

0.479

High

563005

CDK3
Cyclin-dependent kinase 3

1

12

High-throughput

0.479

High

563007

STK4
Serine/threonine-protein kinase 4

1

20

High-throughput

0.479

High

563009

STK3
Serine/threonine-protein kinase 3

1

16

High-throughput

0.479

High

563010

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

14

High-throughput

0.479

High

563011

ELOC
Elongin-C

1

1

High-throughput

0.479

High

563026

OPTN
Optineurin

1

19

Small-scale

0.479

High

563033

TRIM6
Tripartite motif-containing protein 6

1

5

Small-scale

0.479

High

563034

SMYD2
N-lysine methyltransferase SMYD2

1

2

High-throughput

0.479

High

562997

MSX2
Homeobox protein MSX-2

1

0

High-throughput

0.458

High

116744

I3L0N3
Vesicle-fusing ATPase

1

3

High-throughput

0.445

High

346605

TTC4
Tetratricopeptide repeat protein 4

1

13

High-throughput

0.445

High

563003

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

9

High-throughput

0.445

High

563022

FXL14
F-box/LRR-repeat protein 14

1

3

High-throughput

0.445

High

563035

RNF12
E3 ubiquitin-protein ligase RLIM

1

5

High-throughput

0.445

High

563027

LRC39
Leucine-rich repeat-containing protein 39

1

4

Small-scale

0.417

High

95776

E5RHG8
Elongin-C

1

1

High-throughput

0.407

High

117102

J3QQK6
Myelin basic protein

1

1

High-throughput

0.407

High

191882

MAGB3
Melanoma-associated antigen B3

1

7

High-throughput

0.407

High

563006

MFGM
Lactadherin

1

9

High-throughput

0.407

High

563016

RSPO1
R-spondin-1

1

5

High-throughput

0.407

High

563040

RT23
Small ribosomal subunit protein mS23

1

5

High-throughput

0.407

High

562996

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

0

Small-scale

0.292

High

563015

T132A
Transmembrane protein 132A

1

0

High-throughput

0.279

Low

563017

EDRF1
Erythroid differentiation-related factor 1

1

0

High-throughput

0.279

Low

563018

IPIL2
Inositol 1,4,5-trisphosphate receptor-interacting protein-like 2

1

0

High-throughput

0.279

Low

563029

PIGS
GPI-anchor transamidase component PIGS

1

0

High-throughput

0.279

Low

563002

FOXA1
Hepatocyte nuclear factor 3-alpha

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025