HitPredict

Interactor 1: RN169 (Q8NCN4)
E3 ubiquitin-protein ligase RNF169 (EC 2.3.2.27) (RING finger protein 169) (RING-type E3 ubiquitin transferase RNF169)
Gene: RNF169

Interactor 2: UBP7 (Q93009)
Ubiquitin carboxyl-terminal hydrolase 7 (EC 3.4.19.12) (Deubiquitinating enzyme 7) (Herpesvirus-associated ubiquitin-specific protease) (Ubiquitin thioesterase 7) (Ubiquitin-specific-processing protease 7)
Gene: USP7

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	0.60	0.684

Property	Details
Experiments	26496610, 28325877, 30773093
Identification Methods	affinity chromatography technology, x-ray crystallography, enzymatic study, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0016567 - protein ubiquitination GO:0016604 - nuclear body
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 708 Hs			1 1102
+	Hs
		1273788 TRI11_HUMAN (62-383): 5.59e-83: 272: 17.37		UBP7_HUMAN (1-1102): 0: 1165: 100.00
+	Hs
		1223388 TRI22_HUMAN (61-394): 1.26e-77: 259: 13.64		UBP7_HUMAN (1-1102): 0: 1165: 100.00
+	Hs
		536961 TRI27_HUMAN (62-395): 2.25e-76: 256: 14.29		UBP7_HUMAN (1-1102): 0: 1165: 100.00
+	Hs
		1223722 RN168_HUMAN (61-459): 1.85e-65: 228: 23.54		UBP7_HUMAN (1-1102): 0: 1165: 100.00
+	Hs
		1273967 TRI35_HUMAN (51-382): 9.75e-66: 227: 15.61		UBP7_HUMAN (1-1102): 0: 1165: 100.00
+	Hs
		1273857 TRI31_HUMAN (64-308): 8.03e-23: 103: 13.66		UBP7_HUMAN (1-1102): 0: 1165: 100.00
+	Hs
		1173894 TRI35_HUMAN (51-382): 9.75e-66: 227: 15.61		UBP34_HUMAN (125-644): 3.97e-99: 348: 18.81
+	Hs
		1019375 TRI26_HUMAN (54-383): 8.51e-63: 220: 12.95		UBP36_HUMAN (165-651): 1.45e-94: 328: 18.13
+	Hs
		1295898 TRI31_HUMAN (64-308): 8.03e-23: 103: 13.66		UBP47_HUMAN (208-737): 3.48e-107: 368: 26.62