HitPredict

Interactor 1: Q8NEX1 (Q8NEX1)
RING-type E3 ubiquitin transferase (EC 2.3.2.27)
Gene: Q8NEX1

Interactor 2: UB2D4 (Q9Y2X8)
Ubiquitin-conjugating enzyme E2 D4 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme D4) (HBUCE1) (Ubiquitin carrier protein D4) (Ubiquitin-protein ligase D4)
Gene: UBE2D4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.34	1.00	0.590

Property	Details
Experiments	19690564
Identification Methods	two hybrid array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	UQ_con~zf-RING_2
Common GO terms	GO:0070936 - protein K48-linked ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 180 Hs			1 147
+	Hs
		849374 Q8NEX1_HUMAN (1-180): 9.28e-64: 195: 100.00		UB2D1_HUMAN (1-147): 4.61e-83: 241: 91.84
+	Hs
		919791 Q8NEX1_HUMAN (1-180): 9.28e-64: 195: 100.00		UB2D2_HUMAN (1-147): 1.54e-82: 240: 93.20
+	Hs
		895850 Q8NEX1_HUMAN (1-180): 9.28e-64: 195: 100.00		UB2D3_HUMAN (1-147): 1.56e-81: 238: 91.84
+	Hs
		1245518 ZNRF2_HUMAN (21-180): 1.53e-53: 171: 100.00		UB2D4_HUMAN (1-147): 8.89e-84: 243: 100.00
+	Hs
		849375 ZNRF2_HUMAN (21-180): 1.53e-53: 171: 100.00		UB2D1_HUMAN (1-147): 4.61e-83: 241: 91.84
+	Hs
		919793 ZNRF2_HUMAN (21-180): 1.53e-53: 171: 100.00		UB2D2_HUMAN (1-147): 1.54e-82: 240: 93.20
+	Hs
		895853 ZNRF2_HUMAN (21-180): 1.53e-53: 171: 100.00		UB2D3_HUMAN (1-147): 1.56e-81: 238: 91.84
+	Hs
		896497 Q8NEX1_HUMAN (1-180): 9.28e-64: 195: 100.00		UBE2N_HUMAN (4-147): 1.52e-69: 208: 46.53
+	Hs
		1245511 ZNRF2_HUMAN (21-180): 1.53e-53: 171: 100.00		UB2E2_HUMAN (4-146): 3.5e-75: 224: 64.34
+	Hs
		1245509 ZNRF2_HUMAN (21-180): 1.53e-53: 171: 100.00		UB2E3_HUMAN (4-146): 1.24e-74: 223: 64.34
+	Hs
		849373 ZNRF1_HUMAN (12-180): 1.49e-45: 151: 49.46		UB2D1_HUMAN (1-147): 4.61e-83: 241: 91.84
+	Hs
		919790 ZNRF1_HUMAN (12-180): 1.49e-45: 151: 49.46		UB2D2_HUMAN (1-147): 1.54e-82: 240: 93.20
+	Hs
		851850 ZNRF2_HUMAN (21-180): 1.53e-53: 171: 100.00		UB2E1_HUMAN (4-146): 4.67e-73: 218: 64.34
+	Hs
		895849 ZNRF1_HUMAN (12-180): 1.49e-45: 151: 49.46		UB2D3_HUMAN (1-147): 1.56e-81: 238: 91.84
+	Hs
		896498 ZNRF2_HUMAN (21-180): 1.53e-53: 171: 100.00		UBE2N_HUMAN (4-147): 1.52e-69: 208: 46.53
+	Hs
		1242075 ZNRF1_HUMAN (12-180): 1.49e-45: 151: 49.46		UB2E2_HUMAN (4-146): 3.5e-75: 224: 64.34
+	Hs
		1242072 ZNRF1_HUMAN (12-180): 1.49e-45: 151: 49.46		UB2E3_HUMAN (4-146): 1.24e-74: 223: 64.34
+	Hs
		851849 ZNRF1_HUMAN (12-180): 1.49e-45: 151: 49.46		UB2E1_HUMAN (4-146): 4.67e-73: 218: 64.34
+	Hs
		896495 ZNRF1_HUMAN (12-180): 1.49e-45: 151: 49.46		UBE2N_HUMAN (4-147): 1.52e-69: 208: 46.53
+	Zm
		35871 B4FHZ7_MAIZE (20-178): 1.03e-46: 156: 21.74		A0A1D6LTJ2_MAIZE (1-112): 1.23e-60: 186: 76.79