HitPredict

Interactor 1: VATC2 (Q8NEY4)
V-type proton ATPase subunit C 2 (V-ATPase subunit C 2) (Vacuolar proton pump subunit C 2)
Gene: ATP6V1C2

Interactor 2: VATE2 (Q96A05)
V-type proton ATPase subunit E 2 (V-ATPase subunit E 2) (Vacuolar proton pump subunit E 2)
Gene: ATP6V1E2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.71	1.00	0.847

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	V-ATPase_C~vATP-synt_E
Common GO terms	GO:0005829 - cytosol GO:0016241 - regulation of macroautophagy GO:0046961 - proton-transporting ATPase activity, rotational mechanism
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 427 Hs			1 226
+	Hs
		736120 VATC2_HUMAN (1-427): 0: 574: 100.00		VATE1_HUMAN (1-225): 3.66e-98: 286: 76.89
+	Hs
		597723 VATC1_HUMAN (1-427): 1.67e-179: 507: 55.61		VATE1_HUMAN (1-225): 3.66e-98: 286: 76.89
+	Sc
		605411 VATC_YEAST (7-423): 8.37e-135: 394: 30.73		VATE_YEAST (2-225): 2.38e-76: 231: 35.40
+	Dm
		870971 VATC_DROME (1-96): 2.6e-32: 131: 56.70		VATE_DROME (1-224): 4.6e-94: 276: 61.16