Protein: RING1
E3 ubiquitin-protein ligase RING1 (EC 2.3.2.27) (Polycomb complex protein RING1) (RING finger protein 1) (RING-type E3 ubiquitin transferase RING1) (Really interesting new gene 1 protein)

Gene: RING1
Organism: Homo sapiens
Interactions: 190
UniProt ID: Q06587

Gene Ontology (top 5):
GO:0000151 - ubiquitin ligase complex
GO:0001739 - sex chromatin
GO:0003682 - chromatin binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

765432

BMI1
Polycomb complex protein BMI-1

22

19

Small-scale

0.991

High

1055825

RYBP
RING1 and YY1-binding protein

18

20

Small-scale

0.990

High

766085

PCGF2
Polycomb group RING finger protein 2

13

19

Small-scale

0.983

High

1055823

YAF2
YY1-associated factor 2

11

20

High-throughput

0.981

High

1055859

CBX8
Chromobox protein homolog 8

8

20

Small-scale

0.980

High

1055847

RING2
E3 ubiquitin-protein ligase RING2

10

19

Small-scale

0.979

High

1055850

PCGF1
Polycomb group RING finger protein 1

8

19

Small-scale

0.978

High

1055820

PCGF5
Polycomb group RING finger protein 5

9

19

High-throughput

0.977

High

129723

CBX4
E3 SUMO-protein ligase CBX4

10

20

Small-scale

0.976

High

1055851

PCGF6
Polycomb group RING finger protein 6

8

19

Small-scale

0.973

High

1055816

BCOR
BCL-6 corepressor

7

20

Small-scale

0.970

High

1055811

PCGF3
Polycomb group RING finger protein 3

6

19

High-throughput

0.953

High

351384

CBX7
Chromobox protein homolog 7

5

20

Small-scale

0.943

High

338825

CBX6
Chromobox protein homolog 6

5

20

High-throughput

0.940

High

1055806

CBX2
Chromobox protein homolog 2

5

20

Small-scale

0.924

High

906648

UB2D1
Ubiquitin-conjugating enzyme E2 D1

4

20

Small-scale

0.898

High

982170

UB2D2
Ubiquitin-conjugating enzyme E2 D2

4

20

High-throughput

0.898

High

957595

UBE2K
Ubiquitin-conjugating enzyme E2 K

4

20

High-throughput

0.892

High

957066

UB2D3
Ubiquitin-conjugating enzyme E2 D3

3

20

Small-scale

0.868

High

1055875

UB2D4
Ubiquitin-conjugating enzyme E2 D4

3

20

High-throughput

0.861

High

1055813

BCORL
BCL-6 corepressor-like protein 1

2

20

High-throughput

0.811

High

909310

UB2E1
Ubiquitin-conjugating enzyme E2 E1

2

20

Small-scale

0.793

High

1055789

RING1
E3 ubiquitin-protein ligase RING1

2

19

Small-scale

0.793

High

1055842

UB2E2
Ubiquitin-conjugating enzyme E2 E2

2

20

High-throughput

0.791

High

625330

CSK22
Casein kinase II subunit alpha'

9

20

High-throughput

0.757

High

418952

H2A1B
Histone H2A type 1-B/E

2

20

Small-scale

0.755

High

997668

CSK21
Casein kinase II subunit alpha

6

20

High-throughput

0.738

High

1006842

PHC1
Polyhomeotic-like protein 1

6

20

Small-scale

0.736

High

1055822

PHC2
Polyhomeotic-like protein 2

6

20

Small-scale

0.733

High

1055838

LMBL2
Lethal(3)malignant brain tumor-like protein 2

4

20

High-throughput

0.704

High

1055836

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

4

20

Small-scale

0.704

High

1055797

CBX3
Chromobox protein homolog 3

4

20

Small-scale

0.699

High

1055839

UB2E3
Ubiquitin-conjugating enzyme E2 E3

1

20

High-throughput

0.698

High

964879

WDR5
WD repeat-containing protein 5

4

17

High-throughput

0.694

High

591610

H2AX
Histone H2AX

1

20

High-throughput

0.691

High

995000

CSK2B
Casein kinase II subunit beta

4

10

High-throughput

0.691

High

282705

E2F6
Transcription factor E2F6

3

17

Small-scale

0.681

High

992147

SKP1
S-phase kinase-associated protein 1

3

12

High-throughput

0.675

High

1055827

PHC3
Polyhomeotic-like protein 3

3

20

High-throughput

0.667

High

959570

MAX
Protein max

3

17

Small-scale

0.656

High

413688

P53
Cellular tumor antigen p53

2

10

Small-scale

0.646

High

371846

MYC
Myc proto-oncogene protein

3

20

Small-scale

0.640

High

964589

DCAF7
DDB1- and CUL4-associated factor 7

2

20

High-throughput

0.628

High

1014074

CBX1
Chromobox protein homolog 1

2

20

High-throughput

0.628

High

1055800

HDAC1
Histone deacetylase 1

2

11

High-throughput

0.628

High

1055803

TFDP1
Transcription factor Dp-1

2

5

High-throughput

0.628

High

1055821

MGAP
MAX gene-associated protein

2

13

High-throughput

0.628

High

1055830

KDM2B
Lysine-specific demethylase 2B

2

20

High-throughput

0.628

High

1055833

AUTS2
Autism susceptibility gene 2 protein

2

20

Small-scale

0.628

High

507869

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

16

Small-scale

0.618

High

754812

H2B1B
Histone H2B type 1-B

1

20

High-throughput

0.618

High

980716

H2B1C
Histone H2B type 1-C/E/F/G/I

1

20

High-throughput

0.618

High

998244

H31
Histone H3.1

1

20

High-throughput

0.618

High

1016798

H33
Histone H3.3

1

20

High-throughput

0.618

High

1029065

E2F1
Transcription factor E2F1

2

17

Small-scale

0.611

High

1055831

IKBD
NF-kappa-B inhibitor delta

2

12

High-throughput

0.606

High

1055844

ZIM3
Zinc finger imprinted 3

2

8

High-throughput

0.606

High

592993

ACADS
Short-chain specific acyl-CoA dehydrogenase, mitochondrial

2

0

High-throughput

0.602

High

540848

ERG
Transcriptional regulator ERG

2

20

Small-scale

0.595

High

259843

BRD4
Bromodomain-containing protein 4

2

17

High-throughput

0.584

High

944637

KLF3
Krueppel-like factor 3

2

20

High-throughput

0.584

High

1055807

NFIX
Nuclear factor 1 X-type

2

20

High-throughput

0.584

High

907392

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

20

Small-scale

0.578

High

883517

CENPA
Histone H3-like centromeric protein A

1

20

Small-scale

0.575

High

1055876

R4GMX3
Polycomb complex protein BMI-1

1

19

High-throughput

0.575

High

387714

FIBA
Fibrinogen alpha chain [Cleaved into: Fibrinopeptide A; Fibrinogen alpha chain]

2

4

High-throughput

0.574

High

387824

FIBB
Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain]

2

4

High-throughput

0.574

High

387965

FIBG
Fibrinogen gamma chain

2

4

High-throughput

0.574

High

1055858

FBRS
Probable fibrosin-1

2

20

High-throughput

0.574

High

1055802

FHL1
Four and a half LIM domains protein 1

1

12

Small-scale

0.573

High

1055815

FBX38
F-box only protein 38

1

2

High-throughput

0.541

High

1055852

TRI55
Tripartite motif-containing protein 55

1

19

High-throughput

0.541

High

166144

AIM2
Interferon-inducible protein AIM2

1

4

High-throughput

0.536

High

317325

ACL6B
Actin-like protein 6B

1

17

High-throughput

0.536

High

552950

PIP
Prolactin-inducible protein

1

3

High-throughput

0.536

High

833726

KDM5C
Lysine-specific demethylase 5C

1

9

Small-scale

0.536

High

857428

NOTC1
Neurogenic locus notch homolog protein 1

1

4

High-throughput

0.536

High

1055829

KMT2C
Histone-lysine N-methyltransferase 2C

1

20

High-throughput

0.536

High

1055841

SCMH1
Polycomb protein SCMH1

1

20

High-throughput

0.536

High

1055864

RAB6B
Ras-related protein Rab-6B

1

7

High-throughput

0.536

High

1055871

MTUS1
Microtubule-associated tumor suppressor 1

1

20

High-throughput

0.536

High

1055872

MED23
Mediator of RNA polymerase II transcription subunit 23

1

1

High-throughput

0.536

High

1055849

MESP1
Mesoderm posterior protein 1

1

0

Small-scale

0.529

High

75509

B3KSH4
Huntingtin interacting protein 2, isoform CRA_a

1

20

High-throughput

0.528

High

1055810

H31T
Histone H3.1t

1

20

High-throughput

0.527

High

936988

CASP6
Caspase-6

1

6

High-throughput

0.515

High

1055819

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

4

High-throughput

0.515

High

1055835

P55G
Phosphatidylinositol 3-kinase regulatory subunit gamma

1

10

High-throughput

0.508

High

774311

BASI
Basigin

1

8

Small-scale

0.504

High

185631

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

13

High-throughput

0.501

High

421981

A4
Amyloid-beta precursor protein

1

5

High-throughput

0.501

High

951633

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

4

High-throughput

0.501

High

1055860

MOV10
Helicase MOV-10

1

14

Small-scale

0.500

High

299164

FLOT1
Flotillin-1

1

4

High-throughput

0.489

High

370068

CYTS
Cystatin-S

1

1

High-throughput

0.489

High

370189

CYTN
Cystatin-SN

1

1

High-throughput

0.489

High

378981

PIGR
Polymeric immunoglobulin receptor

1

2

High-throughput

0.489

High

1055799

MSLN
Mesothelin

1

1

High-throughput

0.489

High

1055804

FLOT2
Flotillin-2

1

4

High-throughput

0.489

High

1055861

FBSL
Fibrosin-1-like protein

1

20

High-throughput

0.489

High

1055793

GRSF1
G-rich sequence factor 1

1

20

Small-scale

0.481

High

1055837

TRI63
E3 ubiquitin-protein ligase TRIM63

1

18

High-throughput

0.481

High

142961

NFIB
Nuclear factor 1 B-type

1

20

High-throughput

0.479

High

157271

CTRO
Citron Rho-interacting kinase

1

5

High-throughput

0.479

High

172729

XPO1
Exportin-1

1

16

High-throughput

0.479

High

181503

TBXT
T-box transcription factor T

1

13

High-throughput

0.479

High

188613

TYY2
Transcription factor YY2

1

20

Small-scale

0.479

High

224987

TLX3
T-cell leukemia homeobox protein 3

1

20

High-throughput

0.479

High

238499

RAD21
Double-strand-break repair protein rad21 homolog

1

4

Small-scale

0.479

High

279349

TULP3
Tubby-related protein 3

1

4

High-throughput

0.479

High

285230

EED
Polycomb protein EED

1

20

High-throughput

0.479

High

315497

RECQ4
ATP-dependent DNA helicase Q4

1

20

High-throughput

0.479

High

339727

KLF8
Krueppel-like factor 8

1

20

High-throughput

0.479

High

349049

LATS1
Serine/threonine-protein kinase LATS1

1

8

High-throughput

0.479

High

349962

SNAI1
Zinc finger protein SNAI1

1

13

Small-scale

0.479

High

400703

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

8

High-throughput

0.479

High

406093

MYCN
N-myc proto-oncogene protein

1

20

Small-scale

0.479

High

442682

RB
Retinoblastoma-associated protein

1

5

Small-scale

0.479

High

473940

NFIC
Nuclear factor 1 C-type

1

20

High-throughput

0.479

High

542474

TOP2A
DNA topoisomerase 2-alpha

1

5

Small-scale

0.479

High

590411

GATA1
Erythroid transcription factor

1

18

High-throughput

0.479

High

662410

GATA2
Endothelial transcription factor GATA-2

1

18

High-throughput

0.479

High

662562

GATA3
Trans-acting T-cell-specific transcription factor GATA-3

1

18

High-throughput

0.479

High

674145

BRD2
Bromodomain-containing protein 2

1

20

High-throughput

0.479

High

675475

TYY1
Transcriptional repressor protein YY1

1

20

Small-scale

0.479

High

685169

PAX6
Paired box protein Pax-6

1

14

High-throughput

0.479

High

703127

TEAD1
Transcriptional enhancer factor TEF-1

1

1

High-throughput

0.479

High

725248

TLX1
T-cell leukemia homeobox protein 1

1

18

High-throughput

0.479

High

766188

NOS2
Nitric oxide synthase, inducible

1

1

Small-scale

0.479

High

775829

HNF1B
Hepatocyte nuclear factor 1-beta

1

15

High-throughput

0.479

High

776178

SOX6
Transcription factor SOX-6

1

20

High-throughput

0.479

High

833923

HNF4A
Hepatocyte nuclear factor 4-alpha

1

9

High-throughput

0.479

High

886464

CTCF
Transcriptional repressor CTCF

1

9

Small-scale

0.479

High

895707

LHX2
LIM/homeobox protein Lhx2

1

5

High-throughput

0.479

High

928428

TERF1
Telomeric repeat-binding factor 1

1

8

High-throughput

0.479

High

979546

H4
Histone H4

1

9

High-throughput

0.479

High

1024521

VIGLN
Vigilin

1

20

High-throughput

0.479

High

1026329

HSF1
Heat shock factor protein 1

1

2

Small-scale

0.479

High

1045207

TF65
Transcription factor p65

1

7

High-throughput

0.479

High

1050730

MAD1
Max dimerization protein 1

1

18

Small-scale

0.479

High

1052860

HME1
Homeobox protein engrailed-1

1

5

High-throughput

0.479

High

1055790

EP300
Histone acetyltransferase p300

1

20

Small-scale

0.479

High

1055794

NFIA
Nuclear factor 1 A-type

1

20

High-throughput

0.479

High

1055795

FOXI1
Forkhead box protein I1

1

7

High-throughput

0.479

High

1055796

FOXL1
Forkhead box protein L1

1

7

High-throughput

0.479

High

1055805

SMC1A
Structural maintenance of chromosomes protein 1A

1

11

Small-scale

0.479

High

1055808

HAPR1
HUWE1-associated protein modifying stress responses 1

1

1

Small-scale

0.479

High

1055809

TERF2
Telomeric repeat-binding factor 2

1

8

High-throughput

0.479

High

1055812

DCAF6
DDB1- and CUL4-associated factor 6

1

20

High-throughput

0.479

High

1055817

TRI67
Tripartite motif-containing protein 67

1

19

High-throughput

0.479

High

1055818

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

12

High-throughput

0.479

High

1055826

ZBT38
Zinc finger and BTB domain-containing protein 38

1

11

Small-scale

0.479

High

1055828

CSK23
Casein kinase II subunit alpha 3

1

20

High-throughput

0.479

High

1055832

SP7
Transcription factor Sp7

1

20

High-throughput

0.479

High

1055834

SMG7
Nonsense-mediated mRNA decay factor SMG7

1

2

High-throughput

0.479

High

1055843

ZFP42
Zinc finger protein 42 homolog

1

20

Small-scale

0.479

High

1055845

CIC
Protein capicua homolog

1

20

High-throughput

0.479

High

1055846

NEB2
Neurabin-2

1

10

High-throughput

0.479

High

1055848

FEV
Protein FEV

1

20

High-throughput

0.479

High

1055853

FOXQ1
Forkhead box protein Q1

1

9

High-throughput

0.479

High

1055854

TOLIP
Toll-interacting protein

1

1

High-throughput

0.479

High

1055855

SMRCD
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1

1

20

High-throughput

0.479

High

1055857

EGLN3
Prolyl hydroxylase EGLN3

1

3

High-throughput

0.479

High

1055865

ZDH18
Palmitoyltransferase ZDHHC18

1

4

Small-scale

0.479

High

1055866

HECW2
E3 ubiquitin-protein ligase HECW2

1

6

High-throughput

0.479

High

1055867

LHX3
LIM/homeobox protein Lhx3

1

7

High-throughput

0.479

High

1055868

ZRAN1
Ubiquitin thioesterase ZRANB1

1

10

High-throughput

0.479

High

1055869

XPO7
Exportin-7

1

12

High-throughput

0.479

High

1055870

KLF15
Krueppel-like factor 15

1

20

High-throughput

0.479

High

1055873

SMC3
Structural maintenance of chromosomes protein 3

1

11

Small-scale

0.479

High

109392

G5E9A7
DM1 locus, WD repeat containing

1

20

High-throughput

0.470

High

562018

LAMP2
Lysosome-associated membrane glycoprotein 2

1

1

High-throughput

0.470

High

168045

RGS12
Regulator of G-protein signaling 12

1

0

Small-scale

0.458

High

581648

MYOD1
Myoblast determination protein 1

1

0

High-throughput

0.458

High

870642

MAOX
NADP-dependent malic enzyme

1

0

Small-scale

0.458

High

1055792

MN1
Transcriptional activator MN1

1

0

Small-scale

0.458

High

429771

JUN
Transcription factor Jun

1

18

High-throughput

0.445

High

1055798

CTBP1
C-terminal-binding protein 1

1

11

High-throughput

0.445

High

1055801

SNW1
SNW domain-containing protein 1

1

2

High-throughput

0.445

High

1055814

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

5

High-throughput

0.445

High

873908

INAR2
Interferon alpha/beta receptor 2

1

1

Small-scale

0.437

High

1055824

ZDH23
Palmitoyltransferase ZDHHC23

1

8

Small-scale

0.437

High

1055856

PKHA4
Pleckstrin homology domain-containing family A member 4

1

13

High-throughput

0.437

High

1055862

ALG13
UDP-N-acetylglucosamine transferase subunit ALG13

1

10

High-throughput

0.437

High

1055863

KI13B
Kinesin-like protein KIF13B

1

13

High-throughput

0.437

High

1055791

LTOR4
Ragulator complex protein LAMTOR4

1

0

High-throughput

0.279

Low

1055840

PAUF
Pancreatic adenocarcinoma up-regulated factor

1

0

High-throughput

0.279

Low

1055874

LTOR2
Ragulator complex protein LAMTOR2

1

0

High-throughput

0.279

Low

517218

AMY1B
Alpha-amylase 1B

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025