HitPredict

Interactor 1: KBTB8 (Q8NFY9)
Kelch repeat and BTB domain-containing protein 8 (T-cell activation kelch repeat protein) (TA-KRP)
Gene: KBTBD8

Interactor 2: KBTB7 (Q8WVZ9)
Kelch repeat and BTB domain-containing protein 7
Gene: KBTBD7

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.76	1.00	0.876

Property	Details
Experiments	30190310, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	BACK~BTB, BTB~BTB, Kelch_1~Kelch_1
Common GO terms	GO:0005829 - cytosol GO:0031463 - Cul3-RING ubiquitin ligase complex
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 601 Hs			1 684
+	Hs
		1262027 KBTB7_HUMAN (10-598): 1.43e-161: 479: 27.66		KBTB7_HUMAN (1-684): 3.49e-171: 507: 100.00
+	Hs
		1245060 KBTB8_HUMAN (1-601): 1.43e-159: 471: 100.00		KBTB8_HUMAN (42-624): 9.61e-173: 508: 28.14
+	Hs
		1201284 KBTB7_HUMAN (10-598): 1.43e-161: 479: 27.66		KBTB6_HUMAN (1-674): 7.18e-160: 478: 89.76
+	Hs
		1121507 KLH26_HUMAN (10-588): 1.15e-142: 428: 22.31		KLH21_HUMAN (40-629): 5.76e-163: 483: 25.49
+	Hs
		1262043 KBTB7_HUMAN (10-598): 1.43e-161: 479: 27.66		KLH29_HUMAN (420-684): 9.32e-38: 152: 13.25
+	Hs
		1201290 KBTB6_HUMAN (11-598): 3.2e-159: 473: 27.39		KLH29_HUMAN (420-684): 9.32e-38: 152: 13.25
+	Dm
		980055 KELC_DROME (25-599): 2.58e-135: 431: 23.03		KELC_DROME (437-682): 8.05e-51: 193: 15.85
+	Hs
		1245062 KBTB8_HUMAN (1-601): 1.43e-159: 471: 100.00		KLH29_HUMAN (420-684): 9.32e-38: 152: 13.25
+	Hs
		1121506 KLH26_HUMAN (10-588): 1.15e-142: 428: 22.31		KLHL3_HUMAN (406-682): 4.13e-52: 191: 14.65
+	Hs
		1164620 KBTB7_HUMAN (10-598): 1.43e-161: 479: 27.66		KLH24_HUMAN (451-682): 8.39e-31: 129: 12.50
+	Hs
		238074 KLH41_HUMAN (17-592): 4.32e-160: 473: 24.84		KLH41_HUMAN (38-618): 3.22e-31: 131: 22.24
+	Hs
		152492 KLH26_HUMAN (10-588): 1.15e-142: 428: 22.31		ENC1_HUMAN (21-526): 1.64e-37: 149: 24.91
+	Hs
		1121471 KLH26_HUMAN (10-588): 1.15e-142: 428: 22.31		KLH24_HUMAN (451-682): 8.39e-31: 129: 12.50
+	Hs
		307183 KLH26_HUMAN (10-588): 1.15e-142: 428: 22.31		KLHL2_HUMAN (350-483): 4.59e-24: 109: 22.79
+	Hs
		1120765 KLH26_HUMAN (10-588): 1.15e-142: 428: 22.31		KLH12_HUMAN (505-684): 3.93e-20: 96.5: 12.11
+	Hs
		1121502 KLH26_HUMAN (10-588): 1.15e-142: 428: 22.31		KLH13_HUMAN (534-684): 8.28e-19: 92.6: 11.61
+	Hs
		1121501 KLH26_HUMAN (10-588): 1.15e-142: 428: 22.31		KLHL9_HUMAN (534-684): 4.01e-18: 90.7: 12.90
+	Hs
		1121494 KLH26_HUMAN (10-588): 1.15e-142: 428: 22.31		KLH25_HUMAN (511-684): 1.91e-16: 84.9: 14.37
+	Hs
		1121499 KLH26_HUMAN (10-588): 1.15e-142: 428: 22.31		KLH28_HUMAN (269-433): 4.5e-10: 64.9: 11.70