Protein: TRI50
E3 ubiquitin-protein ligase TRIM50 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase TRIM50) (Tripartite motif-containing protein 50)

Gene: TRI50, TRIM50
Organism: Homo sapiens
Interactions: 57
UniProt ID: Q86XT4

Gene Ontology (top 5):
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0008270 - zinc ion binding
GO:0042802 - identical protein binding
GO:0045087 - innate immune response

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

906696

UB2D1
Ubiquitin-conjugating enzyme E2 D1

4

20

Small-scale

0.888

High

982232

UB2D2
Ubiquitin-conjugating enzyme E2 D2

3

20

Small-scale

0.845

High

1294323

UB2E3
Ubiquitin-conjugating enzyme E2 E3

3

20

Small-scale

0.845

High

1294317

TRI50
E3 ubiquitin-protein ligase TRIM50

3

16

Small-scale

0.839

High

572049

TRI27
Zinc finger protein RFP

2

16

High-throughput

0.783

High

931556

RD23A
UV excision repair protein RAD23 homolog A

2

12

High-throughput

0.783

High

957623

UBE2K
Ubiquitin-conjugating enzyme E2 K

2

20

High-throughput

0.783

High

1090764

TRAF2
TNF receptor-associated factor 2

2

18

High-throughput

0.783

High

1294319

LNX1
E3 ubiquitin-protein ligase LNX

2

8

High-throughput

0.783

High

1294325

UB2E2
Ubiquitin-conjugating enzyme E2 E2

3

20

Small-scale

0.755

High

1294335

UB2D4
Ubiquitin-conjugating enzyme E2 D4

3

20

Small-scale

0.755

High

1294318

IQUB
IQ motif and ubiquitin-like domain-containing protein

2

1

High-throughput

0.700

High

1294330

UBTD1
Ubiquitin domain-containing protein 1

2

3

High-throughput

0.700

High

350063

SNAI1
Zinc finger protein SNAI1

2

20

Small-scale

0.624

High

1294333

HDAC6
Protein deacetylase HDAC6

2

5

Small-scale

0.624

High

909341

UB2E1
Ubiquitin-conjugating enzyme E2 E1

1

20

Small-scale

0.621

High

957125

UB2D3
Ubiquitin-conjugating enzyme E2 D3

1

20

Small-scale

0.621

High

957780

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

20

Small-scale

0.621

High

254486

PLPL9
85/88 kDa calcium-independent phospholipase A2

2

5

High-throughput

0.606

High

288457

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

2

19

High-throughput

0.606

High

297833

PIAS2
E3 SUMO-protein ligase PIAS2

2

7

High-throughput

0.606

High

329082

KLHL2
Kelch-like protein 2

2

2

High-throughput

0.606

High

943792

UBS3A
Ubiquitin-associated and SH3 domain-containing protein A

2

9

High-throughput

0.606

High

1057629

CDK18
Cyclin-dependent kinase 18

2

7

High-throughput

0.606

High

1232896

XAF1
XIAP-associated factor 1

2

2

High-throughput

0.606

High

1253059

ZN620
Zinc finger protein 620

2

20

High-throughput

0.606

High

1278715

ZN438
Zinc finger protein 438

2

17

High-throughput

0.606

High

1294321

HMHA1
Rho GTPase-activating protein 45 [Cleaved into: Minor histocompatibility antigen HA-1

2

4

High-throughput

0.606

High

1294324

GCC1
GRIP and coiled-coil domain-containing protein 1

2

10

High-throughput

0.606

High

1294326

AP4AT
AP-4 complex accessory subunit Tepsin

2

2

High-throughput

0.606

High

1294322

LMBL2
Lethal(3)malignant brain tumor-like protein 2

2

0

High-throughput

0.580

High

1294332

SPG21
Maspardin

2

0

High-throughput

0.580

High

557368

SRC
Proto-oncogene tyrosine-protein kinase Src

1

8

Small-scale

0.578

High

1294327

NLRP3
NACHT, LRR and PYD domains-containing protein 3

1

14

Small-scale

0.561

High

889602

CLK2
Dual specificity protein kinase CLK2

2

5

High-throughput

0.553

High

1187648

T10IP
Testis-specific protein 10-interacting protein

2

2

High-throughput

0.553

High

1294329

TSSK3
Testis-specific serine/threonine-protein kinase 3

2

3

High-throughput

0.553

High

1294334

RSP14
Radial spoke head 14 homolog

2

10

High-throughput

0.553

High

893988

MEOX2
Homeobox protein MOX-2

1

11

High-throughput

0.481

High

577814

PLAK
Junction plakoglobin

1

5

Small-scale

0.479

High

858787

BRCC3
Lys-63-specific deubiquitinase BRCC36

1

2

Small-scale

0.479

High

899465

TCPD
T-complex protein 1 subunit delta

1

6

Small-scale

0.479

High

1016503

SRSF3
Serine/arginine-rich splicing factor 3

1

5

Small-scale

0.479

High

1060796

ACK1
Activated CDC42 kinase 1

1

16

Small-scale

0.479

High

1107882

SQSTM
Sequestosome-1

1

6

Small-scale

0.479

High

1117958

PKP1
Plakophilin-1

1

5

Small-scale

0.479

High

1126715

BECN1
Beclin-1

1

3

Small-scale

0.479

High

1294320

NEK7
Serine/threonine-protein kinase Nek7

1

10

Small-scale

0.479

High

1294328

SPB12
Serpin B12

1

6

Small-scale

0.479

High

1232439

Q6FHY5
MEOX2 protein

1

13

High-throughput

0.470

High

1294331

NOD2
Nucleotide-binding oligomerization domain-containing protein 2

1

14

Small-scale

0.457

High

106214

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

64463

F221B
Protein FAM221B

2

0

High-throughput

0.316

High

1206396

EFHC2
EF-hand domain-containing family member C2

2

0

High-throughput

0.316

High

1272772

EPMIP
EPM2A-interacting protein 1

2

0

High-throughput

0.316

High

279410

TULP3
Tubby-related protein 3

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025