HitPredict

Interactor 1: COP1 (Q8NHY2)
E3 ubiquitin-protein ligase COP1 (EC 2.3.2.27) (Constitutive photomorphogenesis protein 1 homolog) (hCOP1) (RING finger and WD repeat domain protein 2) (RING finger protein 200) (RING-type E3 ubiquitin transferase RFWD2)
Gene: COP1

Interactor 2: TRIB3 (Q96RU7)
Tribbles homolog 3 (TRB-3) (Neuronal cell death-inducible putative kinase) (SINK) (p65-interacting inhibitor of NF-kappa-B)
Gene: TRIB3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.93 0.60 0.748

The method score is based on:

Property Details
Experiments 26186194, 28514442, 31125554, 33961781, 32707033, 21572435, 25117710
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation, pull down, tandem affinity purification
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005654 - nucleoplasm
GO:0005829 - cytosol
GO:0032436 - positive regulation of proteasomal ubiquitin-dependent protein catabolic process
Homologous interactions 11

Homologous interactions

Color coding for hit scores

1 731
Hs

1 358
+ Mm
+ Hs
+ Mm
+ Hs
+ Mm
+ Hs
+ Hs
+ Mm
+ Sc
+ Zm
+ Sp

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024