HitPredict

Interactor 1: EIF3F (O00303)
Eukaryotic translation initiation factor 3 subunit F (eIF3f) (Deubiquitinating enzyme eIF3f) (EC 3.4.19.12) (Eukaryotic translation initiation factor 3 subunit 5) (eIF-3-epsilon) (eIF3 p47)
Gene: EIF3F

Interactor 2: HERC2 (O95714)
E3 ubiquitin-protein ligase HERC2 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 2) (HECT-type E3 ubiquitin transferase HERC2)
Gene: HERC2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	30279242, 29426014
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0016020 - membrane
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 357 Hs			1 4834
+	Hs
		176904 EIF3H_HUMAN (84-353): 3.84e-76: 240: 16.17		HERC2_HUMAN (1-4834): 0: 6206: 100.00
+	Hs
		130679 PSDE_HUMAN (81-356): 5.98e-69: 220: 15.31		HERC2_HUMAN (1-4834): 0: 6206: 100.00
+	Hs
		124661 EIF3F_HUMAN (1-357): 2.36e-122: 358: 100.00		WWP2_HUMAN (4317-4794): 2.23e-166: 541: 19.22
+	Hs
		124895 EIF3F_HUMAN (1-357): 2.36e-122: 358: 100.00		HUWE1_HUMAN (4365-4788): 5.93e-118: 425: 24.00
+	Hs
		125011 EIF3H_HUMAN (84-353): 3.84e-76: 240: 16.17		WWP2_HUMAN (4317-4794): 2.23e-166: 541: 19.22
+	Hs
		177087 EIF3H_HUMAN (84-353): 3.84e-76: 240: 16.17		SMUF1_HUMAN (4321-4794): 2.56e-156: 507: 20.58
+	Hs
		849230 PSMD7_HUMAN (88-356): 1.64e-95: 289: 27.27		HUWE1_HUMAN (4365-4788): 5.93e-118: 425: 24.00
+	Hs
		130969 PSDE_HUMAN (81-356): 5.98e-69: 220: 15.31		HUWE1_HUMAN (4365-4788): 5.93e-118: 425: 24.00
+	Hs
		1185006 CSN6_HUMAN (76-357): 3.14e-101: 303: 22.73		HERC5_HUMAN (424-597): 6.72e-11: 71.2: 26.56
+	Hs
		130906 PSDE_HUMAN (81-356): 5.98e-69: 220: 15.31		HERC1_HUMAN (2867-3016): 8.76e-11: 71.4: 12.34