HitPredict

Interactor 1: EIF3F (O00303)
Eukaryotic translation initiation factor 3 subunit F (eIF3f) (Deubiquitinating enzyme eIF3f) (EC 3.4.19.12) (Eukaryotic translation initiation factor 3 subunit 5) (eIF-3-epsilon) (eIF3 p47)
Gene: EIF3F

Interactor 2: EIF3M (Q7L2H7)
Eukaryotic translation initiation factor 3 subunit M (eIF3m) (Fetal lung protein B5) (hFL-B5) (PCI domain-containing protein 1)
Gene: EIF3M

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.96 1.00 0.983

The method score is based on:

Property Details
Experiments 17403899, 32296183, 24981860, 26186194, 28514442, 16169070, 31527668, 33961781, 19615732, 18599441, 23623729, 25416956, unassigned1304
Identification Methods affinity chromatography technology, two hybrid, mass spectrometry studies of complexes, anti tag coimmunoprecipitation, pull down, bimolecular fluorescence complementation, two hybrid array, two hybrid prey pooling approach, mammalian protein protein interaction trap, validated two hybrid and 1 others

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Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains JAB~PCI, MitMem_reg~eIF3m_C_helix, MitMem_reg~PCI
Common GO terms GO:0001732 - formation of cytoplasmic translation initiation complex
GO:0003743 - translation initiation factor activity
GO:0005829 - cytosol
GO:0005852 - eukaryotic translation initiation factor 3 complex
GO:0006413 - translational initiation
and 4 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 357
Hs

1 374
+ Hs
+ Dm
+ Dm
+ Hs
+ Hs
+ Dm
+ Ce
+ Ce
+ Sp
+ Mm
+ Hs
+ Sp
+ Hs
+ Hs
+ Hs
+ Dm
+ Sc
+ Dm
+ At
+ At

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Last updated: 15 Jul 2024