Protein: HBS1L
HBS1-like protein (EC 3.6.5.-) (ERFS)

Gene: HBS1L
Organism: Homo sapiens
Interactions: 116
UniProt ID: Q9Y450

Gene Ontology (top 5):
GO:0003746 - translation elongation factor activity
GO:0003924 - GTPase activity
GO:0005525 - GTP binding
GO:0005829 - cytosol
GO:0006412 - translation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1411965

PELO
Protein pelota homolog

4

7

High-throughput

0.882

High

1353564

DI3L1
DIS3-like exonuclease 1

5

1

Small-scale

0.718

High

1137690

EXOS7
Exosome complex component RRP42

4

4

Small-scale

0.696

High

1384054

EXOS8
Exosome complex component RRP43

4

4

Small-scale

0.696

High

1491130

EXOS1
Exosome complex component CSL4

4

1

Small-scale

0.696

High

1447247

EXOS5
Exosome complex component RRP46

4

5

Small-scale

0.694

High

1447264

EXOS3
Exosome complex component RRP40

5

0

Small-scale

0.689

High

1446211

EXOS4
Exosome complex component RRP41

4

5

Small-scale

0.686

High

138896

STK25
Serine/threonine-protein kinase 25

3

3

High-throughput

0.667

High

772217

MSX2
Homeobox protein MSX-2

3

4

High-throughput

0.667

High

1054530

EXOS9
Exosome complex component RRP45

3

4

Small-scale

0.660

High

1239697

JMJD6
Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

2

1

High-throughput

0.628

High

1387199

RB39B
Ras-related protein Rab-39B

2

3

High-throughput

0.628

High

1138806

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

5

High-throughput

0.618

High

1435489

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.618

High

716491

GFRP
GTP cyclohydrolase 1 feedback regulatory protein

2

0

High-throughput

0.602

High

1332126

EIF1A
Probable RNA-binding protein EIF1AD

2

0

High-throughput

0.602

High

259186

DNJA2
DnaJ homolog subfamily A member 2

2

4

High-throughput

0.601

High

1209135

EXOS6
Exosome complex component MTR3

2

6

Small-scale

0.595

High

1118360

EXOS2
Exosome complex component RRP4

2

0

High-throughput

0.585

High

243378

PRKN
E3 ubiquitin-protein ligase parkin

2

11

High-throughput

0.584

High

1216641

LIN9
Protein lin-9 homolog

2

1

High-throughput

0.574

High

252204

IF4E2
Eukaryotic translation initiation factor 4E type 2

2

2

High-throughput

0.571

High

397302

ESR1
Estrogen receptor

2

9

High-throughput

0.571

High

1128871

NBR1
Next to BRCA1 gene 1 protein

2

0

Small-scale

0.559

High

1006820

SRPK2
SRSF protein kinase 2

1

8

High-throughput

0.550

High

1402655

SRPK1
SRSF protein kinase 1

1

6

High-throughput

0.550

High

952486

UB2G2
Ubiquitin-conjugating enzyme E2 G2

1

2

High-throughput

0.541

High

348811

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

2

High-throughput

0.536

High

451648

GPX1
Glutathione peroxidase 1

1

1

High-throughput

0.536

High

549718

PRPS2
Ribose-phosphate pyrophosphokinase 2

1

1

High-throughput

0.536

High

800434

LICH
Lysosomal acid lipase/cholesteryl ester hydrolase

1

1

High-throughput

0.536

High

957045

CXCR4
C-X-C chemokine receptor type 4

1

2

High-throughput

0.536

High

970193

RS16
Small ribosomal subunit protein uS9

1

1

High-throughput

0.536

High

1114733

CUL3
Cullin-3

1

13

High-throughput

0.536

High

1144229

TEBP
Prostaglandin E synthase 3

1

1

High-throughput

0.536

High

1439312

E41L5
Band 4.1-like protein 5

1

1

High-throughput

0.536

High

1451438

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

1

High-throughput

0.536

High

1439587

GOPC
Golgi-associated PDZ and coiled-coil motif-containing protein

1

3

High-throughput

0.515

High

663380

KTHY
Thymidylate kinase

1

0

High-throughput

0.513

High

1216423

FAXC
Failed axon connections homolog

1

0

High-throughput

0.513

High

1238261

CK087
Uncharacterized protein C11orf87

1

0

High-throughput

0.513

High

423519

A4
Amyloid-beta precursor protein

1

2

High-throughput

0.501

High

508884

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

9

High-throughput

0.501

High

1098869

M3K1
Mitogen-activated protein kinase kinase kinase 1

1

7

Small-scale

0.501

High

1403675

UHRF1
E3 ubiquitin-protein ligase UHRF1

1

6

High-throughput

0.489

High

173602

XPO1
Exportin-1

1

7

High-throughput

0.479

High

316207

RECQ4
ATP-dependent DNA helicase Q4

1

3

High-throughput

0.479

High

346549

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

11

High-throughput

0.479

High

414902

P53
Cellular tumor antigen p53

1

3

High-throughput

0.479

High

463860

LYN
Tyrosine-protein kinase Lyn

1

2

Small-scale

0.479

High

675210

TNR6
Tumor necrosis factor receptor superfamily member 6

1

4

High-throughput

0.479

High

714544

PML
Protein PML

1

3

High-throughput

0.479

High

791867

SYUA
Alpha-synuclein

1

3

High-throughput

0.479

High

831699

CCNF
Cyclin-F

1

3

High-throughput

0.479

High

844125

HD
Huntingtin

1

4

Small-scale

0.479

High

891371

GSK3A
Glycogen synthase kinase-3 alpha

1

6

High-throughput

0.479

High

891908

GSK3B
Glycogen synthase kinase-3 beta

1

8

High-throughput

0.479

High

925629

MOT1
Monocarboxylate transporter 1

1

2

High-throughput

0.479

High

954325

RS20
Small ribosomal subunit protein uS10

1

3

High-throughput

0.479

High

1032277

EXOSX
Exosome complex component 10

1

2

High-throughput

0.479

High

1067872

EP300
Histone acetyltransferase p300

1

3

High-throughput

0.479

High

1247055

RICTR
Rapamycin-insensitive companion of mTOR

1

1

High-throughput

0.479

High

1251478

GGYF2
GRB10-interacting GYF protein 2

1

2

High-throughput

0.479

High

1280629

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

5

High-throughput

0.479

High

1370493

CSN5
COP9 signalosome complex subunit 5

1

11

High-throughput

0.479

High

1393870

DDRGK
DDRGK domain-containing protein 1

1

2

High-throughput

0.479

High

1429031

WWTR1
WW domain-containing transcription regulator protein 1

1

6

High-throughput

0.479

High

1446460

BRD7
Bromodomain-containing protein 7

1

7

High-throughput

0.479

High

1459431

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.479

High

1491323

ARI1
E3 ubiquitin-protein ligase ARIH1

1

9

High-throughput

0.479

High

643157

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

0

High-throughput

0.458

High

1350512

BICD2
Protein bicaudal D homolog 2

1

0

High-throughput

0.458

High

1397131

CEP19
Centrosomal protein of 19 kDa

1

0

High-throughput

0.458

High

1405180

MPH6
M-phase phosphoprotein 6

1

0

High-throughput

0.458

High

1453062

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

1315558

ULK2
Serine/threonine-protein kinase ULK2

1

4

High-throughput

0.445

High

1404536

CDC5L
Cell division cycle 5-like protein

1

2

High-throughput

0.445

High

373590

MYC
Myc proto-oncogene protein

1

9

High-throughput

0.437

High

377800

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

1

High-throughput

0.437

High

412864

NTRK1
High affinity nerve growth factor receptor

1

5

High-throughput

0.437

High

590112

RFA2
Replication protein A 32 kDa subunit

1

5

High-throughput

0.437

High

607263

CEBPB
CCAAT/enhancer-binding protein beta

1

5

High-throughput

0.437

High

696952

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

3

High-throughput

0.437

High

769597

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.437

High

838814

MTREX
Exosome RNA helicase MTR4

1

3

High-throughput

0.437

High

879658

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

4

High-throughput

0.437

High

1096875

RFA4
Replication protein A 30 kDa subunit

1

5

High-throughput

0.437

High

1256231

TRI67
Tripartite motif-containing protein 67

1

8

High-throughput

0.437

High

1277017

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

2

High-throughput

0.437

High

1329963

SIR6
NAD-dependent protein deacylase sirtuin-6

1

2

High-throughput

0.437

High

1461726

HECD1
E3 ubiquitin-protein ligase HECTD1

1

10

High-throughput

0.437

High

1491324

RBM7
RNA-binding protein 7

1

12

High-throughput

0.437

High

1460972

FBX3
F-box only protein 3

1

0

High-throughput

0.426

High

58975

PIPSL
Putative PIP5K1A and PSMD4-like protein

1

2

High-throughput

0.407

High

1111388

SNW1
SNW domain-containing protein 1

1

2

High-throughput

0.407

High

1278836

HDGR2
Hepatoma-derived growth factor-related protein 2

1

1

High-throughput

0.407

High

1390928

LRC46
Leucine-rich repeat-containing protein 46

1

3

High-throughput

0.407

High

1491325

CCG2
Voltage-dependent calcium channel gamma-2 subunit

3

0

High-throughput

0.347

High

1382758

ISOC2
Isochorismatase domain-containing protein 2

2

0

High-throughput

0.328

High

1462789

LAMP3
Lysosome-associated membrane glycoprotein 3

2

0

High-throughput

0.328

High

66911

SPDE4
Speedy protein E4

1

0

High-throughput

0.279

Low

190523

COPT1
High affinity copper uptake protein 1

1

0

High-throughput

0.279

Low

290807

SURF6
Surfeit locus protein 6

1

0

High-throughput

0.279

Low

718491

CD6
T-cell differentiation antigen CD6

1

0

High-throughput

0.279

Low

1200503

H1BP3
HCLS1-binding protein 3

1

0

High-throughput

0.279

Low

1287745

ISCA2
Iron-sulfur cluster assembly 2 homolog, mitochondrial

1

0

High-throughput

0.279

Low

1295136

F90A1
Protein FAM90A1

1

0

High-throughput

0.279

Low

1324615

PIAS4
E3 SUMO-protein ligase PIAS4

1

0

High-throughput

0.279

Low

1331807

F133A
Protein FAM133A

1

0

High-throughput

0.279

Low

1400313

CC85A
Coiled-coil domain-containing protein 85A

1

0

High-throughput

0.279

Low

1414027

MMTA2
Multiple myeloma tumor-associated protein 2

1

0

High-throughput

0.279

Low

279548

TULP3
Tubby-related protein 3

1

0

High-throughput

0.249

Low

1135869

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

High-throughput

0.249

Low

1240278

ZCHC8
Zinc finger CCHC domain-containing protein 8

1

0

High-throughput

0.249

Low

1291612

HOOK3
Protein Hook homolog 3

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025