Protein: GRB2
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2)

Gene: GRB2
Organism: Mus musculus
Interactions: 108
UniProt ID: Q60631

Gene Ontology (top 5):
GO:0001784 - phosphotyrosine residue binding
GO:0005068 - transmembrane receptor protein tyrosine kinase adaptor activity
GO:0005091 - guanyl-nucleotide exchange factor adaptor activity
GO:0005154 - epidermal growth factor receptor binding
GO:0005168 - neurotrophin TRKA receptor binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

957235

SHC1
SHC-transforming protein 1

21

20

Small-scale

0.986

High

964559

EGFR
Epidermal growth factor receptor

9

20

Small-scale

0.970

High

1141170

GAB1
GRB2-associated-binding protein 1

6

20

Small-scale

0.930

High

1141134

SOS1
Son of sevenless homolog 1

4

20

Small-scale

0.887

High

643091

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

2

20

Small-scale

0.834

High

719305

PTN11
Tyrosine-protein phosphatase non-receptor type 11

3

20

Small-scale

0.827

High

970654

SOS2
Son of sevenless homolog 2

3

20

Small-scale

0.812

High

1114082

Q3ZB59
Growth factor receptor bound protein 2-associated protein 2

2

20

Small-scale

0.806

High

574006

PTPRA
Receptor-type tyrosine-protein phosphatase alpha

2

20

Small-scale

0.799

High

101586

F8VQL0
Hepatocyte growth factor receptor

2

20

Small-scale

0.768

High

972995

TIE2
Angiopoietin-1 receptor

1

20

Small-scale

0.766

High

1141127

LCP2
Lymphocyte cytosolic protein 2

2

20

Small-scale

0.755

High

610598

CBL
E3 ubiquitin-protein ligase CBL

8

20

Small-scale

0.744

High

403541

KIT
Mast/stem cell growth factor receptor Kit

2

20

Small-scale

0.743

High

1141132

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

2

19

Small-scale

0.737

High

760474

DYN2
Dynamin-2

2

20

Small-scale

0.726

High

404013

PGFRB
Platelet-derived growth factor receptor beta

1

20

Small-scale

0.724

High

1141164

RGPS2
Ras-specific guanine nucleotide-releasing factor RalGPS2

1

20

Small-scale

0.724

High

1141130

SNTA1
Alpha-1-syntrophin

1

20

Small-scale

0.716

High

710138

FAK1
Focal adhesion kinase 1

2

20

Small-scale

0.695

High

886456

CPNE2
Copine-2

1

4

High-throughput

0.691

High

956520

DOK1
Docking protein 1

1

20

High-throughput

0.691

High

1112541

LRRK1
Leucine-rich repeat serine/threonine-protein kinase 1

1

6

High-throughput

0.691

High

1141126

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

3

20

Small-scale

0.655

High

1112191

PHAG1
Phosphoprotein associated with glycosphingolipid-enriched microdomains 1

1

16

High-throughput

0.646

High

722901

CD22
B-cell receptor CD22

2

20

Small-scale

0.634

High

222775

LAT
Linker for activation of T-cells family member 1

3

9

Small-scale

0.624

High

1141149

FRS2
Fibroblast growth factor receptor substrate 2

3

20

Small-scale

0.624

High

392775

PRIO
Major prion protein

2

1

Small-scale

0.621

High

724599

IRS1
Insulin receptor substrate 1

1

20

Small-scale

0.618

High

763393

FYN
Tyrosine-protein kinase Fyn

1

19

Small-scale

0.618

High

770716

CSF3R
Granulocyte colony-stimulating factor receptor

1

20

Small-scale

0.618

High

872621

EPHB2
Ephrin type-B receptor 2

1

20

Small-scale

0.618

High

946348

IRS2
Insulin receptor substrate 2

1

20

Small-scale

0.618

High

963044

UFO
Tyrosine-protein kinase receptor UFO

1

20

Small-scale

0.618

High

1115913

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

20

Small-scale

0.618

High

1141138

BCR
Breakpoint cluster region protein

1

20

High-throughput

0.618

High

1141165

SHIP1
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

1

20

Small-scale

0.618

High

1141166

SH2B2
SH2B adapter protein 2

1

20

Small-scale

0.618

High

222321

O54737
BCA protein

1

20

High-throughput

0.590

High

654982

VAV
Proto-oncogene vav

1

20

High-throughput

0.590

High

729751

BTK
Tyrosine-protein kinase BTK

1

20

High-throughput

0.590

High

1141129

VAV2
Guanine nucleotide exchange factor VAV2

1

20

High-throughput

0.590

High

1141167

CD2AP
CD2-associated protein

1

19

High-throughput

0.590

High

1141175

GAB2
GRB2-associated-binding protein 2

1

20

High-throughput

0.590

High

1141155

AJUBA
LIM domain-containing protein ajuba

2

20

Small-scale

0.584

High

1141168

SPY2
Protein sprouty homolog 2

2

15

Small-scale

0.584

High

1141169

SPY1
Protein sprouty homolog 1

2

15

Small-scale

0.584

High

420374

PTPRC
Receptor-type tyrosine-protein phosphatase C

1

20

Small-scale

0.575

High

540268

EPOR
Erythropoietin receptor

1

20

Small-scale

0.575

High

593485

KPCA
Protein kinase C alpha type

1

20

Small-scale

0.575

High

760450

DYN1
Dynamin-1

1

20

Small-scale

0.575

High

796503

ZAP70
Tyrosine-protein kinase ZAP-70

1

20

High-throughput

0.575

High

1141133

DLG4
Disks large homolog 4

1

19

High-throughput

0.575

High

1141146

DOCK1
Dedicator of cytokinesis protein 1

1

20

Small-scale

0.575

High

1141147

DYN3
Dynamin-3

1

20

Small-scale

0.575

High

1141143

THMS1
Protein THEMIS

2

2

Small-scale

0.571

High

1141131

ADA12
Disintegrin and metalloproteinase domain-containing protein 12

1

20

Small-scale

0.561

High

1112053

CBLB
E3 ubiquitin-protein ligase CBL-B

2

20

Small-scale

0.552

High

1141135

SYPH
Synaptophysin

1

0

Small-scale

0.537

High

957139

DAB2
Disabled homolog 2

1

20

Small-scale

0.536

High

804959

MERL
Merlin

1

20

Small-scale

0.515

High

1141172

SPY4
Protein sprouty homolog 4

1

15

Small-scale

0.515

High

1119796

KI26A
Kinesin-like protein KIF26A

1

15

Small-scale

0.506

High

1141139

BTLA
B- and T-lymphocyte attenuator

1

0

Small-scale

0.505

High

1141140

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

9

Small-scale

0.501

High

850517

DYLT1
Dynein light chain Tctex-type 1

1

3

High-throughput

0.481

High

904258

HNRPK
Heterogeneous nuclear ribonucleoprotein K

1

20

High-throughput

0.481

High

930488

UBC9
SUMO-conjugating enzyme UBC9

1

1

High-throughput

0.481

High

1112731

SF3B2
Splicing factor 3B subunit 2

1

1

High-throughput

0.481

High

1141137

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

11

High-throughput

0.481

High

1141150

CSTFT
Cleavage stimulation factor subunit 2 tau variant

1

10

High-throughput

0.481

High

1141151

RBM4
RNA-binding protein 4

1

7

High-throughput

0.481

High

1141152

PSPC1
Paraspeckle component 1

1

13

High-throughput

0.481

High

1141161

FIP1
Pre-mRNA 3'-end-processing factor FIP1

1

4

High-throughput

0.481

High

193241

AP1B1
AP-1 complex subunit beta-1

1

17

Small-scale

0.479

High

291640

ZN106
Zinc finger protein 106

1

1

Small-scale

0.479

High

923892

YBOX1
Y-box-binding protein 1

1

1

High-throughput

0.479

High

1113312

SPRY3
Protein sprouty homolog 3

1

15

Small-scale

0.479

High

1141128

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

20

Small-scale

0.479

High

1141141

FACD2
Fanconi anemia group D2 protein homolog

1

5

High-throughput

0.479

High

1141142

WDTC1
WD and tetratricopeptide repeats protein 1

1

11

High-throughput

0.479

High

1141148

A16L1
Autophagy-related protein 16-1

1

17

High-throughput

0.479

High

1141162

RAB13
Ras-related protein Rab-13

1

2

Small-scale

0.479

High

1141171

DOK3
Docking protein 3

1

20

Small-scale

0.479

High

1141173

KHDR2
KH domain-containing, RNA-binding, signal transduction-associated protein 2

1

20

Small-scale

0.479

High

1125637

NUFP2
FMR1-interacting protein NUFIP2

1

0

High-throughput

0.460

High

1141160

CPSF5
Cleavage and polyadenylation specificity factor subunit 5

1

0

High-throughput

0.460

High

82735

B9EKI5
E3 ubiquitin-protein ligase CBL

1

20

High-throughput

0.457

High

1141153

SH3K1
SH3 domain-containing kinase-binding protein 1

1

20

High-throughput

0.457

High

1141157

Q91ZZ2
Guanine nucleotide exchange factor

1

20

High-throughput

0.457

High

1141158

ERRFI
ERBB receptor feedback inhibitor 1

1

20

High-throughput

0.457

High

1141159

UCK2
Uridine-cytidine kinase 2

1

1

High-throughput

0.457

High

1141163

BCAP
Phosphoinositide 3-kinase adapter protein 1

1

8

High-throughput

0.457

High

1141174

PDC6I
Programmed cell death 6-interacting protein

1

20

High-throughput

0.457

High

57750

A2BGG7
Y box protein 1

1

1

High-throughput

0.445

High

906650

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

9

Small-scale

0.445

High

1112482

GARE1
GRB2-associated and regulator of MAPK protein

1

6

Small-scale

0.445

High

1113308

SCIMP
SLP adapter and CSK-interacting membrane protein

1

3

Small-scale

0.445

High

1113707

CARL2
Capping protein, Arp2/3 and myosin-I linker protein 2

1

7

Small-scale

0.445

High

1141136

PEAK1
Inactive tyrosine-protein kinase PEAK1

1

17

Small-scale

0.445

High

1141144

ELMO2
Engulfment and cell motility protein 2

1

3

Small-scale

0.445

High

1141156

SNX18
Sorting nexin-18

1

20

Small-scale

0.445

High

101407

F8VPP8
Zinc finger CCCH type containing 7B

1

17

High-throughput

0.439

High

1141145

Q8BIS2
IF rod domain-containing protein

1

17

High-throughput

0.437

High

1141154

SATB2
DNA-binding protein SATB2

1

0

Small-scale

0.426

High

517637

A4
Amyloid-beta precursor protein

1

11

Small-scale

0.408

High

1060206

Q148Q7
IF rod domain-containing protein

1

18

High-throughput

0.407

High


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Last updated: 15 Jul 2024